Cigarette smoke extracts and cadmium induce COX-2 expression through γ-secretase-mediated p38 MAPK activation in C6 astroglia cells

Exposure to cigarette smoke has been implicated in the progression of cerebrovascular and neurological disorders like stroke through inflammation and blood-brain barrier disruption. In this study, we investigated the signaling cascade activated by cigarette smoke extracts (CSE) and cadmium (Cd) resu...

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Veröffentlicht in:	PloS one 2019-02, Vol.14 (2), p.e0212749
Hauptverfasser:	Lim, Hyun Joung, Park, Jung Hyun, Jo, Chulman, Yoon, Keejung, Koh, Young Ho
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation AKT protein Amyloid Precursor Protein Secretases - metabolism Animals Apoptosis Astrocytes Astrocytes - metabolism Astrocytes - pathology Biology and life sciences Blockage Blood-brain barrier Brain diseases Brain research Cadmium Cadmium - chemistry Cadmium - toxicity Cell Line, Tumor Cigarette smoke Cigarettes Cleavage Cyclic AMP response element-binding protein Cyclic AMP Response Element-Binding Protein - metabolism Cyclooxygenase 2 - biosynthesis Cyclooxygenase-2 Disruption Enzyme Activation - drug effects Exposure Extracellular signal-regulated kinase Gene Expression Regulation, Enzymologic - drug effects Inflammation Inflammatory response Ischemia Kinases MAP kinase MAP Kinase Signaling System - drug effects Medicine and Health Sciences Neurobiology Neurochemistry Neurological diseases Neurosciences Nicastrin Notch1 protein p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation Proteins Rats Receptor, Notch1 - metabolism Secretase Signal transduction Signaling siRNA Smoke Smoke - adverse effects Social Sciences Stroke Tobacco Products - adverse effects
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