Identification of whole blood mRNA and microRNA biomarkers of tissue damage and immune function resulting from amphetamine exposure or heat stroke in adult male rats

This work extends the understanding of how toxic exposures to amphetamine (AMPH) adversely affect the immune system and lead to tissue damage. Importantly, it determines which effects of AMPH are and are not due to pronounced hyperthermia. Whole blood messenger RNA (mRNA) and whole blood and serum m...

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Veröffentlicht in:	PloS one 2019-02, Vol.14 (2), p.e0210273
Hauptverfasser:	Camacho, Luísa, Silva, Camila S, Hanig, Joseph P, Schleimer, Robert P, George, Nysia I, Bowyer, John F
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphetamine - administration & dosage Amphetamine - pharmacology Amphetamine-Related Disorders - blood Amphetamines Analysis Animals Autophagy Beta cells Biocompatibility Bioindicators Biological markers Biology and life sciences Biomarkers Biomarkers - blood Blood Bone marrow Bronchi Bronchus CCR2 protein CCR5 protein CD14 antigen CD18 antigen CD19 antigen Central nervous system agents Cytochrome P-450 Disease Drug abuse Drug dosages Drug use EDTA Exposure Fever Fever - blood Fever - chemically induced Food Gene expression Gene regulation Genes Health risks Heart Heat stroke Heat Stroke - blood Heatstroke HIV Human immunodeficiency virus Hyperthermia Immune response Immune system Innate immunity Kidneys Laboratory animals Liver Liver diseases Lungs Lymphocytes T Male Medicine and Health Sciences Messenger RNA Methamphetamine MicroRNA MicroRNAs MicroRNAs - blood Monocyte chemoattractant protein 1 Muscles Neurotoxicity Pancreas Rats Rats, Sprague-Dawley Research and analysis methods Ribonucleic acid RNA RNA, Messenger - blood Rodents Stroke T cells Tissues Toxicology Transcription Virus diseases
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