Analytical characterization and reference interval of an enzyme-linked immunosorbent assay for active von Willebrand factor

Interaction of von Willebrand factor (VWF) with platelets requires a conformational change that exposes an epitope within the VWF A1 domain, enabling platelet glycoprotein Ibα binding. Quantification of this ''active" conformation of VWF has been shown to provide pathophysiological in...

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Veröffentlicht in:	PloS one 2019-02, Vol.14 (2), p.e0211961-e0211961
Hauptverfasser:	van der Vorm, Lisa N, Li, Li, Huskens, Dana, Chayouâ, Walid, Kelchtermans, Hilde, de Groot, Philip G, Roest, Mark, Remijn, Jasper A, de Laat, Bas
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Analysis Antibodies Antibodies - metabolism Antigenic determinants Antigens Assaying Atherosclerosis Binding Binding sites Biology and Life Sciences Blood plasma Blood platelets Blood Platelets - metabolism Collagen Conformation Correlation Enzyme-linked immunosorbent assay Enzyme-Linked Immunosorbent Assay - methods Enzyme-Linked Immunosorbent Assay - standards Enzymes Epitopes Epitopes - analysis Epitopes - metabolism Female Glycoproteins Health risk assessment Hematology Humans Hypertension Laboratories Linearity Male Mathematical analysis Medicine and Health Sciences Middle Aged Mutation Parameters Physical Sciences Physiology Platelets Reference Values Research and Analysis Methods Ristocetin Shear stress von Willebrand Diseases - blood von Willebrand Diseases - diagnosis Von Willebrand factor von Willebrand Factor - analysis von Willebrand Factor - immunology von Willebrand Factor - metabolism Young Adult
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