Prevention of tooth extraction-triggered bisphosphonate-related osteonecrosis of the jaws with basic fibroblast growth factor: An experimental study in rats

Osteonecrosis of the jaw induced by administration of bisphosphonates (BPs), BP-related osteonecrosis (BRONJ), typically develops after tooth extraction and is medically challenging. As BPs inhibit oral mucosal cell growth, we hypothesized that suppression of the wound healing-inhibiting effects cou...

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Veröffentlicht in:	PloS one 2019-02, Vol.14 (2), p.e0211928-e0211928
Hauptverfasser:	Imada, Mitsuhiko, Yagyuu, Takahiro, Ueyama, Yoshihiro, Maeda, Masahiko, Yamamoto, Kazuhiko, Kurokawa, Satoshi, Jo, Jun-Ichiro, Tabata, Yasuhiko, Tanaka, Yasuhito, Kirita, Tadaaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Angiogenesis Animals Biocompatibility Biodegradation Biology and Life Sciences Biomedical materials Bisphosphonate-Associated Osteonecrosis of the Jaw - diagnostic imaging Bisphosphonate-Associated Osteonecrosis of the Jaw - drug therapy Bisphosphonate-Associated Osteonecrosis of the Jaw - etiology Bisphosphonate-Associated Osteonecrosis of the Jaw - pathology Bisphosphonates Bone disorder agents Bone surgery CAT scans Computed tomography Delayed-Action Preparations - chemistry Disruption Embryos Female Fibroblast growth factor 2 Fibroblast Growth Factor 2 - pharmacokinetics Fibroblast Growth Factor 2 - pharmacology Fibroblast growth factors Fibroblasts Gelatin Gelatin - chemistry Growth factors Humans Hydrogels Hydrogels - chemistry Intravenous administration Jaw Laboratories Mandible Mandible - diagnostic imaging Mandible - drug effects Mandible - pathology Maxillofacial surgery Medicine and Health Sciences Molar - drug effects Molar - pathology Molar - surgery Mouth Mucosa - diagnostic imaging Mouth Mucosa - drug effects Mouth Mucosa - pathology Mucosa Osteonecrosis Phosphates Phosphonates Physical Sciences Rats Rats, Sprague-Dawley Sheets Sockets Teeth Tomography Tooth Extraction - adverse effects Tooth extractions Tooth Socket - diagnostic imaging Tooth Socket - drug effects Tooth Socket - pathology Wound care Wound healing Wound Healing - drug effects X-Ray Microtomography Zoledronic acid Zoledronic Acid - administration & dosage
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