Exploring the effects of electrospun fiber surface nanotopography on neurite outgrowth and branching in neuron cultures

Three aligned, electrospun fiber scaffolds with unique surface features were created from poly-L-lactic acid (PLLA). Fibers without surface nanotopography (smooth fibers), fibers with surface divots (shallow pits), and fibers with surface pits (deeper pits) were fabricated, and fiber alignment, diam...

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Veröffentlicht in:	PloS one 2019-02, Vol.14 (2), p.e0211731-e0211731
Hauptverfasser:	D'Amato, Anthony R, Puhl, Devan L, Ziemba, Alexis M, Johnson, Christopher D L, Doedee, Janneke, Bao, Jonathan, Gilbert, Ryan J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Alignment Animals Axonogenesis Axons Biology and Life Sciences Biomedical engineering Biotechnology Care and treatment Cell adhesion & migration Coated fibers Coating Coatings Dorsal root ganglia Electron microscopy Electrospinning Engineering and Technology Extracellular matrix Extracellular Matrix Proteins - metabolism Fibers Ganglia Ganglia, Spinal - metabolism Ganglia, Spinal - physiology Interdisciplinary aspects Lactic acid Laminin Matrix protein Microscopy Microscopy, Electron, Scanning - methods Morphology Nanotechnology Nanotechnology - methods Nerve Regeneration - physiology Nervous system Neurites - metabolism Neurites - physiology Neuronal Outgrowth - physiology Neurons Neurons - metabolism Neurons - physiology Organic acids Physical properties Physical Sciences Pits Polyesters - chemistry Polylactic acid Proteins Rats Rats, Sprague-Dawley Research and Analysis Methods Risk factors Scanning electron microscopy Spinal cord Spinal cord injuries Tissue engineering Tissue Engineering - methods Tissue Scaffolds Topography
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