A PRRSV GP5-Mosaic vaccine: Protection of pigs from challenge and ex vivo detection of IFNγ responses against several genotype 2 strains

Porcine reproductive and respiratory syndrome virus (PRRSV), is a highly mutable RNA virus that affects swine worldwide and its control is very challenging due to its formidable heterogeneity in the field. In the present study, DNA vaccines constructed with PRRSV GP5-Mosaic sequences were complexed...

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Veröffentlicht in:	PloS one 2019-01, Vol.14 (1), p.e0208801-e0208801
Hauptverfasser:	Cui, Junru, O'Connell, Caitlin M, Costa, Antonio, Pan, Yan, Smyth, Joan A, Verardi, Paulo H, Burgess, Diane J, Van Kruiningen, Herbert J, Garmendia, Antonio E
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animal vaccines Animals Antibodies Antibodies, Neutralizing - immunology Antigens Biology and Life Sciences Blood Deoxyribonucleic acid Disease DNA DNA vaccines Gene expression Gene sequencing Genomes Genotype & phenotype Genotypes Heterogeneity Hogs Hydration Immunogenicity Immunology Interferon Interferon-gamma - metabolism Laboratories Leukocytes (mononuclear) Leukocytes, Mononuclear - metabolism Liposomes Livestock Lungs Medicine and Health Sciences Methods Natural resources Neutralizing Nucleotide sequence Peripheral blood mononuclear cells Pharmaceutical sciences Pharmacy Phylogenetics Porcine Reproductive and Respiratory Syndrome Porcine respiratory and reproductive syndrome virus - immunology Porcine respiratory and reproductive syndrome virus - pathogenicity Proteins Research and Analysis Methods Ribonucleic acid RNA RNA viruses RNA, Messenger - metabolism Stimulation Strains (organisms) Swine Tuberculosis Vaccines Viral Proteins - immunology Viral Vaccines - immunology Viral Vaccines - therapeutic use Viruses γ-Interferon
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