Lapachol and synthetic derivatives: in vitro and in vivo activities against Bothrops snake venoms

It is known that local tissue injuries incurred by snakebites are quickly instilled causing extensive, irreversible, tissue destruction that may include loss of limb function or even amputation. Such injuries are not completely neutralized by the available antivenins, which in general are focused on...

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Veröffentlicht in:	PloS one 2019-01, Vol.14 (1), p.e0211229
Hauptverfasser:	Strauch, Marcelo A, Tomaz, Marcelo Amorim, Monteiro-Machado, Marcos, Cons, Bruno Lemos, Patrão-Neto, Fernando Chagas, Teixeira-Cruz, Jhonatha da Mota, Tavares-Henriques, Matheus da Silva, Nogueira-Souza, Pâmella Dourila, Gomes, Sara L S, Costa, Paulo R R, Schaeffer, Edgar, da Silva, Alcides J M, Melo, Paulo A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amputation Analogs Animals Antivenom Bark Bioassays Biological products Biology and Life Sciences Bites (Injuries) Blood Coagulation - drug effects Bothrops Bothrops atrox Collagen Collagenase Collagenases - chemistry Collagenases - metabolism Drug therapy Edema Enzymatic activity Enzymes Hemorrhage In vivo methods and tests Inflammation Inhibition Injuries Medicine and Health Sciences Metalloproteinase Mice Naphthoquinones - chemistry Naphthoquinones - metabolism Naphthoquinones - pharmacology Natural products Neurotoxins - genetics Neurotoxins - metabolism Phospholipase Phospholipase A2 Phospholipases Phospholipases A2 - chemistry Phospholipases A2 - metabolism Physiological aspects Properties Proteolysis Quinone Quinones Skin Snake bites Snake Venoms - metabolism Snakes Studies Tissues Venom Venom toxins Venomous snakes Venoms
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