Effect of Sec61 interaction with Mpd1 on endoplasmic reticulum-associated degradation

Proteins that misfold in the endoplasmic reticulum (ER) are transported back to the cytosol for ER-associated degradation (ERAD). The Sec61 channel is one of the candidates for the retrograde transport conduit. Channel opening from the ER lumen must be triggered by ERAD factors and substrates. Here...

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Veröffentlicht in:	PloS one 2019-01, Vol.14 (1), p.e0211180-e0211180
Hauptverfasser:	Pereira, Fabio, Rettel, Mandy, Stein, Frank, Savitski, Mikhail M, Collinson, Ian, Römisch, Karin
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding sites Bioinformatics Biology and Life Sciences Channel opening Crosslinking Cytosol Degradation Endoplasmic reticulum Endoplasmic Reticulum - genetics Endoplasmic Reticulum - metabolism Endoplasmic Reticulum-Associated Degradation Gene expression Mass spectrometry Mass spectroscopy Medicine and Health Sciences Membrane proteins Molecular biology Mutagenesis Organic chemistry Physical Sciences Physiological aspects Plasmids Protein Binding Protein Disulfide-Isomerases - genetics Protein Disulfide-Isomerases - metabolism Protein transport Protein-protein interactions Proteins Proteomics Repressor Proteins - genetics Repressor Proteins - metabolism Research and Analysis Methods Retrograde transport Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Scientific imaging SEC Translocation Channels - genetics SEC Translocation Channels - metabolism Studies Substrates Temperature Yeast
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