MALDI imaging mass spectrometry revealed atropine distribution in the ocular tissues and its transit from anterior to posterior regions in the whole-eye of rabbit after topical administration

It is essential to elucidate drug distribution in the ocular tissues and drug transit in the eye for ophthalmic pharmaceutical manufacturers. Atropine is a reversible muscarinic receptor used to treat various diseases. However, its distribution in ocular tissues is still incompletely understood. Mat...

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Veröffentlicht in:	PloS one 2019-01, Vol.14 (1), p.e0211376
Hauptverfasser:	Mori, Naoto, Mochizuki, Takaharu, Yamazaki, Fumiyoshi, Takei, Shiro, Mano, Hidetoshi, Matsugi, Takeshi, Setou, Mitsutoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine receptors (muscarinic) Administration, Topical Animals Atropine Atropine - analysis Atropine - metabolism Biological properties Biological samples Biology and Life Sciences Chromatography Chromatography, High Pressure Liquid Cornea Dosage and administration Drugs Eye Eye - chemistry Eye - metabolism Eye - pathology Health aspects Ionization Ions Laboratories Liquid chromatography Macular degeneration Male Mass spectrometry Mass spectroscopy Medicine Medicine and Health Sciences Menisci Metabolites Pharmaceuticals Photonics Physical Sciences Physiological aspects R&D Rabbits Research & development Research and Analysis Methods Scientific imaging Spatial distribution Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Spectroscopy Tissue Distribution Tissues Transit
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