Differential Impacts of HIV status on short-term fertility desires among couples in Rakai, Uganda

Fertility desires of female and male partners in current relationships are often correlated. We examined the influence of HIV seropositive status of female and male partners on short-term fertility desires in Rakai, Uganda, a setting with high fertility and HIV infection rates. Participants were cou...

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Veröffentlicht in:PloS one 2019-01, Vol.14 (1), p.e0210935-e0210935
Hauptverfasser: Song, Xiaoyu, Grilo, Stephanie A, Mathur, Sanyukta, Lutalo, Tom, Ssekubugu, Robert, Nalugoda, Fred, Santelli, John S
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Grilo, Stephanie A
Mathur, Sanyukta
Lutalo, Tom
Ssekubugu, Robert
Nalugoda, Fred
Santelli, John S
description Fertility desires of female and male partners in current relationships are often correlated. We examined the influence of HIV seropositive status of female and male partners on short-term fertility desires in Rakai, Uganda, a setting with high fertility and HIV infection rates. Participants were couples (15-49 years old) enrolled in the Rakai Community Cohort Study, from 2011 to 2013 (n = 2,291). Cohen's kappa coefficient was used to measure the correlation of female and male partners' short-term fertility desires (measured as 'wanting a child in the next 12 months'), in both total sample and stratified serostatus groups. HIV serostatus and additional characteristics of female and male partners were included in Poisson regression models to estimate the rate ratios (RR) for each partner's short-term fertility desires. Individual and partner characteristics included HIV status, partner HIV status, age in years, partner age in years, educational attainment, number of living children, community of residence, and socioeconomic status (SES). Short-term fertility desires among female and male partners were moderately associated (Kappa = 0.37, p-value
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We examined the influence of HIV seropositive status of female and male partners on short-term fertility desires in Rakai, Uganda, a setting with high fertility and HIV infection rates. Participants were couples (15-49 years old) enrolled in the Rakai Community Cohort Study, from 2011 to 2013 (n = 2,291). Cohen's kappa coefficient was used to measure the correlation of female and male partners' short-term fertility desires (measured as 'wanting a child in the next 12 months'), in both total sample and stratified serostatus groups. HIV serostatus and additional characteristics of female and male partners were included in Poisson regression models to estimate the rate ratios (RR) for each partner's short-term fertility desires. Individual and partner characteristics included HIV status, partner HIV status, age in years, partner age in years, educational attainment, number of living children, community of residence, and socioeconomic status (SES). Short-term fertility desires among female and male partners were moderately associated (Kappa = 0.37, p-value&lt;0.001). The association was weakest among female sero-positive and male sero-negative couples (Kappa = 0.29, p-value&lt;0.001). When adjusting for parity and other covariates in the model, women's short-term fertility desires were significantly associated with their positive sero-status regardless of male partners' sero-status (adjRR = 1.58, p&lt;0.001 for F+M-; adjRR = 1.33, p = 0.001 for F+M+; in comparison with F-M-). Men's short-term fertility desires were significantly associated with their positive sero-status, in addition to their female partners' positive sero-status (adjRR = 1.23 with p-value = 0.022 for F-M+; adjRR = 1.42 with p-value&lt;0.001 for F+M-; adjRR = 1.26 with p-value&lt;0.001 for F+M+; in comparison with F-M-). When the differential effect of parity was included in the model, similar associations remained for both female and male partners when the number of living children was small, but largely reduced when the number of living children was large (3 or more). Female and male partners in couple dyads demonstrated moderate agreements about short-term fertility desires. The HIV seropositive status of female partners was most strongly associated with short-term fertility desires of both genders, and this association was even stronger for women who had few or no living children.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0210935</identifier><identifier>PMID: 30677068</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acquired immune deficiency syndrome ; Adolescent ; Adult ; Age ; AIDS ; Analysis ; Biology and Life Sciences ; Birth control ; Care and treatment ; Children ; Cohort Studies ; Communities ; Correlation analysis ; Couples ; Decision making ; Desire ; Disease prevention ; Family planning ; Family Planning Services ; Female ; Fertility ; Health aspects ; Health sciences ; HIV ; HIV infections ; HIV Infections - complications ; HIV Infections - epidemiology ; HIV Infections - physiopathology ; HIV Seronegativity ; HIV Seropositivity - epidemiology ; HIV Seropositivity - physiopathology ; HIV Seroprevalence ; Human immunodeficiency virus ; Humans ; Male ; Medicine and Health Sciences ; Middle Aged ; Parity ; People and Places ; Poisson density functions ; Population ; Pregnancy ; Pregnancy Complications, Infectious - epidemiology ; Pregnancy Complications, Infectious - physiopathology ; Public health ; Regression analysis ; Regression models ; Reproductive health ; Research and Analysis Methods ; Risk factors ; Sexual Partners ; Sexually transmitted diseases ; Short term ; Social Class ; Socio-economic aspects ; Socioeconomics ; Statistical analysis ; STD ; Studies ; Surveys and Questionnaires ; Uganda - epidemiology ; Womens health ; Young Adult</subject><ispartof>PloS one, 2019-01, Vol.14 (1), p.e0210935-e0210935</ispartof><rights>COPYRIGHT 2019 Public Library of Science</rights><rights>2019 Song et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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We examined the influence of HIV seropositive status of female and male partners on short-term fertility desires in Rakai, Uganda, a setting with high fertility and HIV infection rates. Participants were couples (15-49 years old) enrolled in the Rakai Community Cohort Study, from 2011 to 2013 (n = 2,291). Cohen's kappa coefficient was used to measure the correlation of female and male partners' short-term fertility desires (measured as 'wanting a child in the next 12 months'), in both total sample and stratified serostatus groups. HIV serostatus and additional characteristics of female and male partners were included in Poisson regression models to estimate the rate ratios (RR) for each partner's short-term fertility desires. Individual and partner characteristics included HIV status, partner HIV status, age in years, partner age in years, educational attainment, number of living children, community of residence, and socioeconomic status (SES). Short-term fertility desires among female and male partners were moderately associated (Kappa = 0.37, p-value&lt;0.001). The association was weakest among female sero-positive and male sero-negative couples (Kappa = 0.29, p-value&lt;0.001). When adjusting for parity and other covariates in the model, women's short-term fertility desires were significantly associated with their positive sero-status regardless of male partners' sero-status (adjRR = 1.58, p&lt;0.001 for F+M-; adjRR = 1.33, p = 0.001 for F+M+; in comparison with F-M-). Men's short-term fertility desires were significantly associated with their positive sero-status, in addition to their female partners' positive sero-status (adjRR = 1.23 with p-value = 0.022 for F-M+; adjRR = 1.42 with p-value&lt;0.001 for F+M-; adjRR = 1.26 with p-value&lt;0.001 for F+M+; in comparison with F-M-). When the differential effect of parity was included in the model, similar associations remained for both female and male partners when the number of living children was small, but largely reduced when the number of living children was large (3 or more). Female and male partners in couple dyads demonstrated moderate agreements about short-term fertility desires. The HIV seropositive status of female partners was most strongly associated with short-term fertility desires of both genders, and this association was even stronger for women who had few or no living children.</description><subject>Acquired immune deficiency syndrome</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>AIDS</subject><subject>Analysis</subject><subject>Biology and Life Sciences</subject><subject>Birth control</subject><subject>Care and treatment</subject><subject>Children</subject><subject>Cohort Studies</subject><subject>Communities</subject><subject>Correlation analysis</subject><subject>Couples</subject><subject>Decision making</subject><subject>Desire</subject><subject>Disease prevention</subject><subject>Family planning</subject><subject>Family Planning Services</subject><subject>Female</subject><subject>Fertility</subject><subject>Health aspects</subject><subject>Health sciences</subject><subject>HIV</subject><subject>HIV infections</subject><subject>HIV Infections - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Song, Xiaoyu</au><au>Grilo, Stephanie A</au><au>Mathur, Sanyukta</au><au>Lutalo, Tom</au><au>Ssekubugu, Robert</au><au>Nalugoda, Fred</au><au>Santelli, John S</au><au>Withers, Mellissa H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential Impacts of HIV status on short-term fertility desires among couples in Rakai, Uganda</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2019-01-24</date><risdate>2019</risdate><volume>14</volume><issue>1</issue><spage>e0210935</spage><epage>e0210935</epage><pages>e0210935-e0210935</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Fertility desires of female and male partners in current relationships are often correlated. We examined the influence of HIV seropositive status of female and male partners on short-term fertility desires in Rakai, Uganda, a setting with high fertility and HIV infection rates. Participants were couples (15-49 years old) enrolled in the Rakai Community Cohort Study, from 2011 to 2013 (n = 2,291). Cohen's kappa coefficient was used to measure the correlation of female and male partners' short-term fertility desires (measured as 'wanting a child in the next 12 months'), in both total sample and stratified serostatus groups. HIV serostatus and additional characteristics of female and male partners were included in Poisson regression models to estimate the rate ratios (RR) for each partner's short-term fertility desires. Individual and partner characteristics included HIV status, partner HIV status, age in years, partner age in years, educational attainment, number of living children, community of residence, and socioeconomic status (SES). Short-term fertility desires among female and male partners were moderately associated (Kappa = 0.37, p-value&lt;0.001). The association was weakest among female sero-positive and male sero-negative couples (Kappa = 0.29, p-value&lt;0.001). When adjusting for parity and other covariates in the model, women's short-term fertility desires were significantly associated with their positive sero-status regardless of male partners' sero-status (adjRR = 1.58, p&lt;0.001 for F+M-; adjRR = 1.33, p = 0.001 for F+M+; in comparison with F-M-). Men's short-term fertility desires were significantly associated with their positive sero-status, in addition to their female partners' positive sero-status (adjRR = 1.23 with p-value = 0.022 for F-M+; adjRR = 1.42 with p-value&lt;0.001 for F+M-; adjRR = 1.26 with p-value&lt;0.001 for F+M+; in comparison with F-M-). When the differential effect of parity was included in the model, similar associations remained for both female and male partners when the number of living children was small, but largely reduced when the number of living children was large (3 or more). Female and male partners in couple dyads demonstrated moderate agreements about short-term fertility desires. The HIV seropositive status of female partners was most strongly associated with short-term fertility desires of both genders, and this association was even stronger for women who had few or no living children.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>30677068</pmid><doi>10.1371/journal.pone.0210935</doi><tpages>e0210935</tpages><orcidid>https://orcid.org/0000-0002-3481-3865</orcidid><oa>free_for_read</oa></addata></record>
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subjects Acquired immune deficiency syndrome
Adolescent
Adult
Age
AIDS
Analysis
Biology and Life Sciences
Birth control
Care and treatment
Children
Cohort Studies
Communities
Correlation analysis
Couples
Decision making
Desire
Disease prevention
Family planning
Family Planning Services
Female
Fertility
Health aspects
Health sciences
HIV
HIV infections
HIV Infections - complications
HIV Infections - epidemiology
HIV Infections - physiopathology
HIV Seronegativity
HIV Seropositivity - epidemiology
HIV Seropositivity - physiopathology
HIV Seroprevalence
Human immunodeficiency virus
Humans
Male
Medicine and Health Sciences
Middle Aged
Parity
People and Places
Poisson density functions
Population
Pregnancy
Pregnancy Complications, Infectious - epidemiology
Pregnancy Complications, Infectious - physiopathology
Public health
Regression analysis
Regression models
Reproductive health
Research and Analysis Methods
Risk factors
Sexual Partners
Sexually transmitted diseases
Short term
Social Class
Socio-economic aspects
Socioeconomics
Statistical analysis
STD
Studies
Surveys and Questionnaires
Uganda - epidemiology
Womens health
Young Adult
title Differential Impacts of HIV status on short-term fertility desires among couples in Rakai, Uganda
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