Comparison of metabolic changes for stone risks in 24-hour urine between non- and postmenopausal women

To explore the differences of 24-hour urine compositions associated with urolithiasis between non- and postmenopausal females. The 24-hour urine samples of female participants were collected from May 2013 to July 2014 along with national cross-sectional study of urolithiasis among adults aged ≥18 ye...

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Veröffentlicht in:PloS one 2019-01, Vol.14 (1), p.e0208893-e0208893
Hauptverfasser: Mai, Zanlin, Li, Xiaoxia, Jiang, Chonghe, Liu, Yongda, Chen, Yiwen, Wu, Wenqi, Zeng, Guohua
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container_title PloS one
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creator Mai, Zanlin
Li, Xiaoxia
Jiang, Chonghe
Liu, Yongda
Chen, Yiwen
Wu, Wenqi
Zeng, Guohua
description To explore the differences of 24-hour urine compositions associated with urolithiasis between non- and postmenopausal females. The 24-hour urine samples of female participants were collected from May 2013 to July 2014 along with national cross-sectional study of urolithiasis among adults aged ≥18 years in China. The exclusion criteria for the participants were: serum creatinine > 133μmol/L, with urinary tract infection, gout, hyperthyroidism, malignancy, had a history of cancer, kidney stones, enterectomy, had taken thiazide diuretics, allopurinol, vitamin supplement, potassium citrate or calcium supplements during the past two weeks. The compositions associated with urinary stone in 24-hour urine were measured and compared between non-and postmenopausal women. A total of 603 24-hour urine samples of female participants were analyzed. 354 women with a mean age of 52.5± 14.03 (range 19-84) years met the criteria, including 160 non-menopausal women and 194 postmenopausal women. Compared to the non-menopausal women, postmenopausal women had a lower secretion of citrate (p = 0.043), magnesium (p = 0.001) and creatinine (p = 0.001) in 24h urine. Multivariate linear regression analysis showed that the menopause status was associated with the changes in magnesium (p = 0.003) and creatinine (p = 0.002) secretion, whereas not with the changes in citrate (p = 0.402) secretion. Postmenopausal women have a significant lower secretion of magnesium in their 24-hour urine than non-menopausal ones. We suppose that might be associated with increased risk of urinary stone formation among postmenopausal women.
doi_str_mv 10.1371/journal.pone.0208893
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The 24-hour urine samples of female participants were collected from May 2013 to July 2014 along with national cross-sectional study of urolithiasis among adults aged ≥18 years in China. The exclusion criteria for the participants were: serum creatinine &gt; 133μmol/L, with urinary tract infection, gout, hyperthyroidism, malignancy, had a history of cancer, kidney stones, enterectomy, had taken thiazide diuretics, allopurinol, vitamin supplement, potassium citrate or calcium supplements during the past two weeks. The compositions associated with urinary stone in 24-hour urine were measured and compared between non-and postmenopausal women. A total of 603 24-hour urine samples of female participants were analyzed. 354 women with a mean age of 52.5± 14.03 (range 19-84) years met the criteria, including 160 non-menopausal women and 194 postmenopausal women. Compared to the non-menopausal women, postmenopausal women had a lower secretion of citrate (p = 0.043), magnesium (p = 0.001) and creatinine (p = 0.001) in 24h urine. Multivariate linear regression analysis showed that the menopause status was associated with the changes in magnesium (p = 0.003) and creatinine (p = 0.002) secretion, whereas not with the changes in citrate (p = 0.402) secretion. Postmenopausal women have a significant lower secretion of magnesium in their 24-hour urine than non-menopausal ones. 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The 24-hour urine samples of female participants were collected from May 2013 to July 2014 along with national cross-sectional study of urolithiasis among adults aged ≥18 years in China. The exclusion criteria for the participants were: serum creatinine &gt; 133μmol/L, with urinary tract infection, gout, hyperthyroidism, malignancy, had a history of cancer, kidney stones, enterectomy, had taken thiazide diuretics, allopurinol, vitamin supplement, potassium citrate or calcium supplements during the past two weeks. The compositions associated with urinary stone in 24-hour urine were measured and compared between non-and postmenopausal women. A total of 603 24-hour urine samples of female participants were analyzed. 354 women with a mean age of 52.5± 14.03 (range 19-84) years met the criteria, including 160 non-menopausal women and 194 postmenopausal women. 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urine</subject><subject>Malignancy</subject><subject>Medicine and Health Sciences</subject><subject>Menopause</subject><subject>Menstruation</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Nephrolithiasis</subject><subject>Nutrition research</subject><subject>Physical Sciences</subject><subject>Post-menopause</subject><subject>Postmenopausal women</subject><subject>Postmenopause - urine</subject><subject>Potassium</subject><subject>Regression analysis</subject><subject>Risk assessment</subject><subject>Risk Factors</subject><subject>Secretion</subject><subject>Stone</subject><subject>Surgery</subject><subject>Urinary Calculi - etiology</subject><subject>Urinary Calculi - urine</subject><subject>Urinary stones</subject><subject>Urinary tract</subject><subject>Urine</subject><subject>Urolithiasis</subject><subject>Urolithiasis - etiology</subject><subject>Urolithiasis - urine</subject><subject>Urology</subject><subject>Womens health</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk1uL1DAUx4so7rr6DUQDguhDx9yapi_CMngZWFjw9hrSNp3JmCbdJHX125vudJep7IP0oe3J7_zPLSfLniO4QqRE7_Zu9Faa1eCsWkEMOa_Ig-wUVQTnDEPy8Oj7JHsSwh7CgnDGHmcnBLKyhISeZt3a9YP0OjgLXAd6FWXtjG5As5N2qwLonAchphggQT8D0BZgmu9ScDB6ncy1itdKWWCdzYG0LRhciL2ybpBjkAZcu_TzNHvUSRPUs_l9ln3_-OHb-nN-cflpsz6_yJsS8Zh3LVYNxoXkpGo5RrxgmHCIeCcR57RChLKuqmlFCK45JaigEKZKeFkUmCXrWfbyoDsYF8TcoiAwKmGFCSUwEZsD0Tq5F4PXvfR_hJNa3Bic3wrpo26MEpLRlE7LZVGWFHUVx6puIcFFS2qIKUpa7-doY92rtlE2emkWossTq3di634JRmhB2ZTMm1nAu6tRhSh6HRpljLTKjTd5V5SlwRYJffUPen91M7WVqQBtO5fiNpOoOC8mCnM-Uat7qPS0qtdNmnWnk33h8HbhkJiofsdtmnAQm69f_p-9_LFkXx-xOyVN3AVnxqidDUuQHsDGuxC86u6ajKCY1uG2G2JaBzGvQ3J7cTygO6fb-0_-AnUzAlQ</recordid><startdate>20190124</startdate><enddate>20190124</enddate><creator>Mai, Zanlin</creator><creator>Li, Xiaoxia</creator><creator>Jiang, Chonghe</creator><creator>Liu, Yongda</creator><creator>Chen, Yiwen</creator><creator>Wu, Wenqi</creator><creator>Zeng, Guohua</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-3790-6434</orcidid></search><sort><creationdate>20190124</creationdate><title>Comparison of metabolic changes for stone risks in 24-hour urine between non- and postmenopausal women</title><author>Mai, Zanlin ; Li, Xiaoxia ; Jiang, Chonghe ; Liu, Yongda ; Chen, Yiwen ; Wu, Wenqi ; Zeng, Guohua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c718t-fd2ec225a839d821856238018fa188491346f9b49332b84315400770875526933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Adults</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Allopurinol</topic><topic>Analysis</topic><topic>Biology and Life Sciences</topic><topic>Calcium</topic><topic>Calculi</topic><topic>Cancer</topic><topic>Citric acid</topic><topic>Citric Acid - urine</topic><topic>Composition</topic><topic>Creatinine</topic><topic>Creatinine - urine</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes</topic><topic>Diuretics</topic><topic>Female</topic><topic>Females</topic><topic>Gout</topic><topic>Health aspects</topic><topic>Hormone replacement therapy</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hyperthyroidism</topic><topic>Kidney Calculi - etiology</topic><topic>Kidney Calculi - urine</topic><topic>Kidney stones</topic><topic>Laboratories</topic><topic>Laparoscopy</topic><topic>Linear Models</topic><topic>Lithiasis</topic><topic>Magnesium</topic><topic>Magnesium - urine</topic><topic>Malignancy</topic><topic>Medicine and Health Sciences</topic><topic>Menopause</topic><topic>Menstruation</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Nephrolithiasis</topic><topic>Nutrition research</topic><topic>Physical Sciences</topic><topic>Post-menopause</topic><topic>Postmenopausal women</topic><topic>Postmenopause - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mai, Zanlin</au><au>Li, Xiaoxia</au><au>Jiang, Chonghe</au><au>Liu, Yongda</au><au>Chen, Yiwen</au><au>Wu, Wenqi</au><au>Zeng, Guohua</au><au>Smith, Rebecca Lee</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of metabolic changes for stone risks in 24-hour urine between non- and postmenopausal women</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2019-01-24</date><risdate>2019</risdate><volume>14</volume><issue>1</issue><spage>e0208893</spage><epage>e0208893</epage><pages>e0208893-e0208893</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To explore the differences of 24-hour urine compositions associated with urolithiasis between non- and postmenopausal females. The 24-hour urine samples of female participants were collected from May 2013 to July 2014 along with national cross-sectional study of urolithiasis among adults aged ≥18 years in China. The exclusion criteria for the participants were: serum creatinine &gt; 133μmol/L, with urinary tract infection, gout, hyperthyroidism, malignancy, had a history of cancer, kidney stones, enterectomy, had taken thiazide diuretics, allopurinol, vitamin supplement, potassium citrate or calcium supplements during the past two weeks. The compositions associated with urinary stone in 24-hour urine were measured and compared between non-and postmenopausal women. A total of 603 24-hour urine samples of female participants were analyzed. 354 women with a mean age of 52.5± 14.03 (range 19-84) years met the criteria, including 160 non-menopausal women and 194 postmenopausal women. Compared to the non-menopausal women, postmenopausal women had a lower secretion of citrate (p = 0.043), magnesium (p = 0.001) and creatinine (p = 0.001) in 24h urine. Multivariate linear regression analysis showed that the menopause status was associated with the changes in magnesium (p = 0.003) and creatinine (p = 0.002) secretion, whereas not with the changes in citrate (p = 0.402) secretion. Postmenopausal women have a significant lower secretion of magnesium in their 24-hour urine than non-menopausal ones. We suppose that might be associated with increased risk of urinary stone formation among postmenopausal women.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>30677034</pmid><doi>10.1371/journal.pone.0208893</doi><tpages>e0208893</tpages><orcidid>https://orcid.org/0000-0002-3790-6434</orcidid><oa>free_for_read</oa></addata></record>
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subjects Adult
Adults
Aged
Aged, 80 and over
Allopurinol
Analysis
Biology and Life Sciences
Calcium
Calculi
Cancer
Citric acid
Citric Acid - urine
Composition
Creatinine
Creatinine - urine
Cross-Sectional Studies
Diabetes
Diuretics
Female
Females
Gout
Health aspects
Hormone replacement therapy
Hospitals
Humans
Hyperthyroidism
Kidney Calculi - etiology
Kidney Calculi - urine
Kidney stones
Laboratories
Laparoscopy
Linear Models
Lithiasis
Magnesium
Magnesium - urine
Malignancy
Medicine and Health Sciences
Menopause
Menstruation
Metabolism
Middle Aged
Multivariate Analysis
Nephrolithiasis
Nutrition research
Physical Sciences
Post-menopause
Postmenopausal women
Postmenopause - urine
Potassium
Regression analysis
Risk assessment
Risk Factors
Secretion
Stone
Surgery
Urinary Calculi - etiology
Urinary Calculi - urine
Urinary stones
Urinary tract
Urine
Urolithiasis
Urolithiasis - etiology
Urolithiasis - urine
Urology
Womens health
title Comparison of metabolic changes for stone risks in 24-hour urine between non- and postmenopausal women
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