Clinical significance of cancer specific methylation of the CDO1 gene in small bowel cancer

Although small bowel cancer (SBC) is extremely rare, its prognosis is poor, and molecular mechanism of the SBC development remains unclear. The aim of our study is to elucidate whether DNA methylation of the promoter region of the cancer-specific methylation gene, cysteine dioxygenase 1 (CDO1), cont...

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Veröffentlicht in:	PloS one 2019-01, Vol.14 (1), p.e0211108
Hauptverfasser:	Kojima, Keita, Nakamura, Takatoshi, Ooizumi, Yosuke, Igarashi, Kazuharu, Tanaka, Toshimichi, Yokoi, Keigo, Ishii, Satoru, Nishizawa, Nobuyuki, Katoh, Hiroshi, Kosaka, Yoshimasa, Sato, Takeo, Watanabe, Masahiko, Yamashita, Keishi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Analysis Biology and life sciences Cancer Carcinogenesis Carcinogens Cell Line, Tumor Chemotherapy Clinical significance Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - enzymology Colorectal Neoplasms - genetics Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Cysteine dioxygenase Cysteine Dioxygenase - genetics Cysteine Dioxygenase - metabolism Deoxyribonucleic acid Development and progression Disease-Free Survival DNA DNA Methylation DNA, Neoplasm - genetics DNA, Neoplasm - metabolism Esophagus Female Gallbladder Gastric cancer Gastrointestinal cancer Gastrointestinal Stromal Tumors - enzymology Gastrointestinal Stromal Tumors - genetics Gastrointestinal Stromal Tumors - mortality Gastrointestinal Stromal Tumors - pathology Genes Genetic aspects Humans Leiomyosarcoma - enzymology Leiomyosarcoma - genetics Leiomyosarcoma - mortality Leiomyosarcoma - pathology Lymphoma Lymphoma - enzymology Lymphoma - genetics Lymphoma - mortality Lymphoma - pathology Male Medical prognosis Medicine Medicine and Health Sciences Middle Aged Mucosa Mutation Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Patients Physical Sciences Prognosis Proteins R&D Research & development Research and Analysis Methods Retrospective Studies Small intestine Small intestine cancer Stomach cancer Surgery Survival Rate Tissues Tumors Variance analysis
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