Synergistic antitumor effects of 9.2.27-PE38KDEL and ABT-737 in primary and metastatic brain tumors

Standard treatment, unfortunately, yields a poor prognosis for patients with primary or metastatic cancers in the central nervous system, indicating a necessity for novel therapeutic agents. Immunotoxins (ITs) are a class of promising therapeutic candidates produced by fusing antibody fragments with...

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Veröffentlicht in:	PloS one 2019-01, Vol.14 (1), p.e0210608
Hauptverfasser:	Yu, Xin, Dobrikov, Mikhail, Keir, Stephen T, Gromeier, Matthias, Pastan, Ira H, Reisfeld, Ralph, Bigner, Darell D, Chandramohan, Vidyalakshmi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Anticancer properties Antigens Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Antineoplastic Combined Chemotherapy Protocols - pharmacology Antineoplastic Combined Chemotherapy Protocols - therapeutic use Antitumor activity Apoptosis Bcl-2 protein Benzothiazoles - pharmacology Benzothiazoles - therapeutic use Biology and Life Sciences Biphenyl Compounds - pharmacology Biphenyl Compounds - therapeutic use Brain Brain cancer Brain Neoplasms - drug therapy Brain Neoplasms - secondary Brain tumors Breast cancer Cancer therapies Care and treatment Cell Death - drug effects Cell Line, Tumor Central nervous system Central nervous system diseases Chemical compounds Chemotherapy Chondroitin sulfate Chondroitin Sulfate Proteoglycans - metabolism Cytotoxicity Drug Synergism Endocytosis - drug effects Exotoxins Exotoxins - pharmacology Furin - pharmacology Glioblastoma Health aspects Humans Immunotoxins Immunotoxins - pharmacology Immunotoxins - therapeutic use Isoquinolines - pharmacology Isoquinolines - therapeutic use Kinases Laboratories Lung cancer Medicine and Health Sciences Melanoma Membrane Proteins - metabolism Metastases Metastasis Mice, Nude Models, Biological Neurosurgery Nitrophenols - pharmacology Nitrophenols - therapeutic use Pancreatic cancer Pathology Patients Pharmacology Piperazines - pharmacology Piperazines - therapeutic use Poly(ADP-ribose) polymerase Prognosis Proteins Proteoglycans Proto-Oncogene Proteins c-bcl-2 - metabolism Pyrimidines - pharmacology Pyrimidines - therapeutic use Research and Analysis Methods Sensitivity enhancement Signal Transduction - drug effects Sulfonamides - pharmacology Sulfonamides - therapeutic use Survival Analysis Synergistic effect Thiophenes - pharmacology Thiophenes - therapeutic use Time Factors Toxicity Tumor cell lines Tumors Xenograft Model Antitumor Assays Xenografts Xenotransplantation
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