Small molecule inhibition of IRE1α kinase/RNase has anti-fibrotic effects in the lung

Endoplasmic reticulum stress (ER stress) has been implicated in the pathogenesis of idiopathic pulmonary fibrosis (IPF), a disease of progressive fibrosis and respiratory failure. ER stress activates a signaling pathway called the unfolded protein response (UPR) that either restores homeostasis or p...

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Veröffentlicht in:	PloS one 2019-01, Vol.14 (1), p.e0209824
Hauptverfasser:	Thamsen, Maike, Ghosh, Rajarshi, Auyeung, Vincent C, Brumwell, Alexis, Chapman, Harold A, Backes, Bradley J, Perara, Gayani, Maly, Dustin J, Sheppard, Dean, Papa, Feroz R
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveolar Epithelial Cells - drug effects Alveolar Epithelial Cells - metabolism Alveolar Epithelial Cells - pathology Alveoli Animals Apoptosis Apoptosis - drug effects Attenuators Biochemistry Biology Biology and Life Sciences Bleomycin Cell Line Critical care Diabetes Disease Endoplasmic reticulum Endoplasmic Reticulum Stress - drug effects Endoribonucleases - antagonists & inhibitors Epithelial cells Exposure Fibrosis Fibrosis - drug therapy Fibrosis - metabolism Fibrosis - pathology Homeostasis Inhibitors Kinases Lung - drug effects Lung - metabolism Lung - pathology Lung diseases Lungs Medicine Medicine and Health Sciences Mice Mutation Pathogenesis Protein folding Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Protein Serine-Threonine Kinases - antagonists & inhibitors Proteins Pulmonary fibrosis Research and Analysis Methods Respiration Respiratory failure Signal transduction Signaling Sleep Stress Surfactants Transcription factors Unfolded Protein Response - drug effects
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