Biological evaluation of isoflavonoids from Genista halacsyi using estrogen-target cells: Activities of glucosides compared to aglycones

The purpose of this study was to evaluate the response of estrogen target cells to a series of isoflavone glucosides and aglycones from Genista halacsyi Heldr. The methanolic extract of aerial parts of this plant was processed using fast centrifugal partition chromatography, resulting in isolation o...

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Veröffentlicht in:	PloS one 2019-01, Vol.14 (1), p.e0210247-e0210247
Hauptverfasser:	Fokialakis, Nikolas, Alexi, Xanthippi, Aligiannis, Nektarios, Boulaka, Athina, Meligova, Aggeliki K, Lambrinidis, George, Kalpoutzakis, Eleftherios, Pratsinis, Harris, Cheilari, Antigoni, Mitsiou, Dimitra J, Mitakou, Sofia, Alexis, Michael N
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Affinity Aglycones Alkaline phosphatase Animals Anti-inflammatory agents Binding Bioavailability Biocompatibility Biology Biology and Life Sciences Biomedical materials Biotechnology Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell death Cell Differentiation Cell growth Cell Proliferation Cells, Cultured Chromatography Daidzein Differentiation Effectiveness Endocrinology Estrogen receptors Estrogens Estrogens - metabolism Female Flavonoids - pharmacology Formulations Gene expression Genista Genista - chemistry Genistein Glucosides Glucosides - pharmacology Health aspects Hippocampus Humans Inflammation Isoflavones Isoflavonoids Kinases Lipopolysaccharides Low concentrations Medicine and Health Sciences Menopause Mice Natural products Osteoblastogenesis Osteoblasts Osteoblasts - cytology Osteoblasts - drug effects Osteoblasts - metabolism Osteoclastogenesis Osteoclasts Oxidative stress Pharmaceutical sciences Pharmacy Plant Extracts - pharmacology Receptors Receptors, Estrogen - genetics Receptors, Estrogen - metabolism Research and Analysis Methods Sex hormones Soy products Systematic review Transcription Tumor necrosis factor-TNF
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