Aging and the relationships between long-axis systolic and early diastolic excursion, isovolumic relaxation time and left ventricular length-Implications for the interpretation of aging effects on e
Both the left ventricular (LV) long-axis peak early diastolic lengthening velocity (e`) and long-axis early diastolic excursion (EDExc) decrease with age, but the mechanisms underlying these decreases are not fully understood. The aim of this study was to investigate the relative contributions to ag...
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| description | Both the left ventricular (LV) long-axis peak early diastolic lengthening velocity (e`) and long-axis early diastolic excursion (EDExc) decrease with age, but the mechanisms underlying these decreases are not fully understood. The aim of this study was to investigate the relative contributions to aging-related decreases in e`and EDExc from LV long-axis systolic excursion (SExc), isovolumic relaxation time (IVRT, as a measure of the speed of relaxation) and LV end-diastolic length (LVEDL).
The study group was 50 healthy adult subjects of ages 17-75 years with a normal LV ejection fraction. SExc, EDExc, e`and IVRT were measured from pulsed wave tissue Doppler signals acquired from the septal and lateral walls. Multivariate modelling was performed to identify independent predictors of EDExc and e`which were consistent for the septal and lateral walls.
EDExc decreased with age and the major determinant of EDExc was SExc, which also decreased with age. There was also a decrease of e`with age, and the major determinant of e`was EDExc. IVRT decreased with age and on univariate analysis was not only inversely correlated with EDExc and e`, but also with SExc. IVRT was only a minor contributor to models of EDExc which included SExc, and was an inconsistent contributor to models of e`which included EDExc. LVEDL decreased with age independent of sex and body size, and was positively correlated with SExc, EDExc and e`.
Major mechanisms underlying the decrease in e`seen during aging are the concomitant decreases in long-axis contraction and early diastolic excursion, which are in turn related in part to long-axis remodelling of the left ventricle. After adjusting for the extent of systolic and early diastolic excursion, slowing of relaxation, as reflected in prolongation of the IVRT, makes no more than a minor contribution to aging-related decreases in EDExc and e`. |
| doi_str_mv | 10.1371/journal.pone.0210277 |
| format | Article |
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The study group was 50 healthy adult subjects of ages 17-75 years with a normal LV ejection fraction. SExc, EDExc, e`and IVRT were measured from pulsed wave tissue Doppler signals acquired from the septal and lateral walls. Multivariate modelling was performed to identify independent predictors of EDExc and e`which were consistent for the septal and lateral walls.
EDExc decreased with age and the major determinant of EDExc was SExc, which also decreased with age. There was also a decrease of e`with age, and the major determinant of e`was EDExc. IVRT decreased with age and on univariate analysis was not only inversely correlated with EDExc and e`, but also with SExc. IVRT was only a minor contributor to models of EDExc which included SExc, and was an inconsistent contributor to models of e`which included EDExc. LVEDL decreased with age independent of sex and body size, and was positively correlated with SExc, EDExc and e`.
Major mechanisms underlying the decrease in e`seen during aging are the concomitant decreases in long-axis contraction and early diastolic excursion, which are in turn related in part to long-axis remodelling of the left ventricle. After adjusting for the extent of systolic and early diastolic excursion, slowing of relaxation, as reflected in prolongation of the IVRT, makes no more than a minor contribution to aging-related decreases in EDExc and e`.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0210277</identifier><identifier>PMID: 30615676</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Age ; Aged ; Aging ; Aging (Biology) ; Aging - physiology ; Biology and Life Sciences ; Blood Flow Velocity ; Blood pressure ; Body mass index ; Body size ; Consent ; Contraction ; Correlation analysis ; Diabetes ; Diastole ; Echocardiography, Doppler, Pulsed ; Female ; Health aspects ; Heart ; Heart Ventricles - physiopathology ; Humans ; Hypertension ; Male ; Medicine and Health Sciences ; Middle Aged ; Multivariate analysis ; People and Places ; Physical Sciences ; Prolongation ; Prospective Studies ; Relaxation time ; Studies ; Systole ; Velocity ; Ventricle ; Ventricular Dysfunction, Left - physiopathology ; Ventricular Function, Left - physiology ; Young Adult</subject><ispartof>PloS one, 2019-01, Vol.14 (1), p.e0210277-e0210277</ispartof><rights>COPYRIGHT 2019 Public Library of Science</rights><rights>2019 Roger E. Peverill. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 Roger E. Peverill 2019 Roger E. Peverill</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-cd74ecd4aaf74f7380f8ab0e747954dbcf50932941c7ae5374db89bba9b4fdca3</citedby><cites>FETCH-LOGICAL-c758t-cd74ecd4aaf74f7380f8ab0e747954dbcf50932941c7ae5374db89bba9b4fdca3</cites><orcidid>0000-0002-3319-5356</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322720/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322720/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30615676$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Fukai, Tohru</contributor><creatorcontrib>Peverill, Roger E</creatorcontrib><title>Aging and the relationships between long-axis systolic and early diastolic excursion, isovolumic relaxation time and left ventricular length-Implications for the interpretation of aging effects on e</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Both the left ventricular (LV) long-axis peak early diastolic lengthening velocity (e`) and long-axis early diastolic excursion (EDExc) decrease with age, but the mechanisms underlying these decreases are not fully understood. The aim of this study was to investigate the relative contributions to aging-related decreases in e`and EDExc from LV long-axis systolic excursion (SExc), isovolumic relaxation time (IVRT, as a measure of the speed of relaxation) and LV end-diastolic length (LVEDL).
The study group was 50 healthy adult subjects of ages 17-75 years with a normal LV ejection fraction. SExc, EDExc, e`and IVRT were measured from pulsed wave tissue Doppler signals acquired from the septal and lateral walls. Multivariate modelling was performed to identify independent predictors of EDExc and e`which were consistent for the septal and lateral walls.
EDExc decreased with age and the major determinant of EDExc was SExc, which also decreased with age. There was also a decrease of e`with age, and the major determinant of e`was EDExc. IVRT decreased with age and on univariate analysis was not only inversely correlated with EDExc and e`, but also with SExc. IVRT was only a minor contributor to models of EDExc which included SExc, and was an inconsistent contributor to models of e`which included EDExc. LVEDL decreased with age independent of sex and body size, and was positively correlated with SExc, EDExc and e`.
Major mechanisms underlying the decrease in e`seen during aging are the concomitant decreases in long-axis contraction and early diastolic excursion, which are in turn related in part to long-axis remodelling of the left ventricle. After adjusting for the extent of systolic and early diastolic excursion, slowing of relaxation, as reflected in prolongation of the IVRT, makes no more than a minor contribution to aging-related decreases in EDExc and e`.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Aging</subject><subject>Aging (Biology)</subject><subject>Aging - physiology</subject><subject>Biology and Life Sciences</subject><subject>Blood Flow Velocity</subject><subject>Blood pressure</subject><subject>Body mass index</subject><subject>Body size</subject><subject>Consent</subject><subject>Contraction</subject><subject>Correlation analysis</subject><subject>Diabetes</subject><subject>Diastole</subject><subject>Echocardiography, Doppler, Pulsed</subject><subject>Female</subject><subject>Health aspects</subject><subject>Heart</subject><subject>Heart Ventricles - physiopathology</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Multivariate analysis</subject><subject>People and Places</subject><subject>Physical Sciences</subject><subject>Prolongation</subject><subject>Prospective Studies</subject><subject>Relaxation time</subject><subject>Studies</subject><subject>Systole</subject><subject>Velocity</subject><subject>Ventricle</subject><subject>Ventricular Dysfunction, Left - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peverill, Roger E</au><au>Fukai, Tohru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aging and the relationships between long-axis systolic and early diastolic excursion, isovolumic relaxation time and left ventricular length-Implications for the interpretation of aging effects on e</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2019-01-07</date><risdate>2019</risdate><volume>14</volume><issue>1</issue><spage>e0210277</spage><epage>e0210277</epage><pages>e0210277-e0210277</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Both the left ventricular (LV) long-axis peak early diastolic lengthening velocity (e`) and long-axis early diastolic excursion (EDExc) decrease with age, but the mechanisms underlying these decreases are not fully understood. The aim of this study was to investigate the relative contributions to aging-related decreases in e`and EDExc from LV long-axis systolic excursion (SExc), isovolumic relaxation time (IVRT, as a measure of the speed of relaxation) and LV end-diastolic length (LVEDL).
The study group was 50 healthy adult subjects of ages 17-75 years with a normal LV ejection fraction. SExc, EDExc, e`and IVRT were measured from pulsed wave tissue Doppler signals acquired from the septal and lateral walls. Multivariate modelling was performed to identify independent predictors of EDExc and e`which were consistent for the septal and lateral walls.
EDExc decreased with age and the major determinant of EDExc was SExc, which also decreased with age. There was also a decrease of e`with age, and the major determinant of e`was EDExc. IVRT decreased with age and on univariate analysis was not only inversely correlated with EDExc and e`, but also with SExc. IVRT was only a minor contributor to models of EDExc which included SExc, and was an inconsistent contributor to models of e`which included EDExc. LVEDL decreased with age independent of sex and body size, and was positively correlated with SExc, EDExc and e`.
Major mechanisms underlying the decrease in e`seen during aging are the concomitant decreases in long-axis contraction and early diastolic excursion, which are in turn related in part to long-axis remodelling of the left ventricle. After adjusting for the extent of systolic and early diastolic excursion, slowing of relaxation, as reflected in prolongation of the IVRT, makes no more than a minor contribution to aging-related decreases in EDExc and e`.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>30615676</pmid><doi>10.1371/journal.pone.0210277</doi><tpages>e0210277</tpages><orcidid>https://orcid.org/0000-0002-3319-5356</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adolescent Adult Age Aged Aging Aging (Biology) Aging - physiology Biology and Life Sciences Blood Flow Velocity Blood pressure Body mass index Body size Consent Contraction Correlation analysis Diabetes Diastole Echocardiography, Doppler, Pulsed Female Health aspects Heart Heart Ventricles - physiopathology Humans Hypertension Male Medicine and Health Sciences Middle Aged Multivariate analysis People and Places Physical Sciences Prolongation Prospective Studies Relaxation time Studies Systole Velocity Ventricle Ventricular Dysfunction, Left - physiopathology Ventricular Function, Left - physiology Young Adult |
| title | Aging and the relationships between long-axis systolic and early diastolic excursion, isovolumic relaxation time and left ventricular length-Implications for the interpretation of aging effects on e |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T14%3A56%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Aging%20and%20the%20relationships%20between%20long-axis%20systolic%20and%20early%20diastolic%20excursion,%20isovolumic%20relaxation%20time%20and%20left%20ventricular%20length-Implications%20for%20the%20interpretation%20of%20aging%20effects%20on%20e&rft.jtitle=PloS%20one&rft.au=Peverill,%20Roger%20E&rft.date=2019-01-07&rft.volume=14&rft.issue=1&rft.spage=e0210277&rft.epage=e0210277&rft.pages=e0210277-e0210277&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0210277&rft_dat=%3Cgale_plos_%3EA568671858%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2164549174&rft_id=info:pmid/30615676&rft_galeid=A568671858&rft_doaj_id=oai_doaj_org_article_3a9d97f73321400f8b6e82a790e3c90c&rfr_iscdi=true |