Constraints-based analysis identifies NAD+ recycling through metabolic reprogramming in antibiotic resistant Chromobacterium violaceum

In the post genomic era, high throughput data augment stoichiometric flux balance models to compute accurate metabolic flux states, growth and energy phenotypes. Investigating altered metabolism in the context of evolved resistant genotypes potentially provide simple strategies to overcome drug resi...

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Veröffentlicht in:	PloS one 2019-01, Vol.14 (1), p.e0210008-e0210008
Hauptverfasser:	Banerjee, Deepanwita, Raghunathan, Anu
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic acid Anti-Bacterial Agents - pharmacology Antibiotic resistance Antibiotics ATP Bacteria BASIC BIOLOGICAL SCIENCES Biology and Life Sciences Biomass Chemical engineering Chloramphenicol Chloromycetin Chromobacterium Chromobacterium - drug effects chromobacterium violaceum Citric Acid - metabolism Citric Acid Cycle - drug effects Data Mining Decoupling drug metabolism Drug resistance Electron transfer Energy metabolism Flow cytometry Fluctuations Flux Genes Genetic engineering Genomes Genomics Genotypes Glucose Glucose - metabolism Homeostasis Infections Laboratories Mathematical models Medicine and Health Sciences Membrane potential Metabolic flux Metabolism Metabolites NAD NAD - metabolism NADH Nicotinamide adenine dinucleotide Opportunist infection Overflow Oxalic Acid - metabolism oxidation-reduction reactions oxygen metabolism Pareto analysis Pathogens Phenotypes Physical Sciences Physiology Populations Predictions Proteins Protonmotive force pyruvate Redox properties Rewiring Sensitizing Shelf life Shunt resistance Streptomycin Tricarboxylic acid cycle
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