Characterization of a protozoan Phosducin-like protein-3 (PhLP-3) reveals conserved redox activity

We recently identified three novel thioredoxin-like genes in the genome of the protozoan parasite Plasmodium that belong to the Phosducin-like family of proteins (PhLP). PhLPs are small cytosolic proteins hypothesized to function in G-protein signaling and protein folding. Although PhLPs are highly...

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Veröffentlicht in:	PloS one 2018-12, Vol.13 (12), p.e0209699
Hauptverfasser:	Kooistra, Rachel L, David, Robin, Ruiz, Ana C, Powers, Sean W, Haselton, Kyle J, Kiernan, Kaitlyn, Blagborough, Andrew M, Solamen, Ligin, Olsen, Kenneth W, Putonti, Catherine, Kanzok, Stefan M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antioxidants Biochemistry Bioinformatics Biological Evolution Biology Biology and Life Sciences Butyl hydroperoxide Cell division Cellular communication Chaperones Cloning, Molecular Conserved sequence Cytoskeleton Eukaryotes Evolution, Molecular Folding Gene Expression Gene Expression Regulation Genomes Homology Humans Life cycle analysis Life cycle engineering Life cycles Malaria Mammals Medicine and Health Sciences Models, Molecular Mosquitoes Mutagenesis, Site-Directed Organic compounds Oxidation-Reduction Parasites Parasitology Phosducin Physical Sciences Plasmodium Plasmodium - genetics Plasmodium - metabolism Protein folding Proteins Protozoa Protozoan Proteins - chemistry Protozoan Proteins - genetics Protozoan Proteins - isolation & purification Protozoan Proteins - metabolism Research and Analysis Methods Site-directed mutagenesis Structure-Activity Relationship Thioredoxin Transcription Yeast
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