Blockade of platelet-derived growth factor receptor-β, not receptor-α ameliorates bleomycin-induced pulmonary fibrosis in mice

Platelet-derived growth factor (PDGF) has been implicated in the pathogenesis of pulmonary fibrosis. Nintedanib, a multi-kinase inhibitor that targets several tyrosine kinases, including PDGF receptor (PDGFR), was recently approved as an anti-fibrotic agent to reduce the deterioration of FVC in pati...

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Veröffentlicht in:	PloS one 2018-12, Vol.13 (12), p.e0209786-e0209786
Hauptverfasser:	Kishi, Masami, Aono, Yoshinori, Sato, Seidai, Koyama, Kazuya, Azuma, Momoyo, Abe, Shuichi, Kawano, Hiroshi, Kishi, Jun, Toyoda, Yuko, Okazaki, Hiroyasu, Ogawa, Hirohisa, Uehara, Hisanori, Nishioka, Yasuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveoli Animals Antibodies Antibodies, Monoclonal - therapeutic use Apoptosis Biology and Life Sciences Bleomycin Bleomycin - toxicity Blocking antibodies Bronchoalveolar Lavage Bronchoalveolar Lavage Fluid Bronchus Cell proliferation Cell Proliferation - drug effects Cells, Cultured Collagen Enzyme inhibitors Epithelial cells Female Fibroblasts Fibroblasts - drug effects Fibroblasts - metabolism Fibrosis Flow Cytometry Genotype & phenotype Growth factors Immunoblotting Immunoglobulins Immunohistochemistry Inflammation Kinases Laboratories Lung diseases Lungs Medicine Medicine and Health Sciences Mice Mice, Inbred C57BL Pathogenesis Phosphorylation Platelet-derived growth factor Pulmonary fibrosis Pulmonary Fibrosis - chemically induced Pulmonary Fibrosis - drug therapy Rats Receptor, Platelet-Derived Growth Factor alpha - antagonists & inhibitors Receptor, Platelet-Derived Growth Factor beta - antagonists & inhibitors Research and Analysis Methods Rheumatology Thymidine Tyrosine
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