Antibody engineering to generate SKY59, a long-acting anti-C5 recycling antibody

Modulating the complement system is a promising strategy in drug discovery for disorders with uncontrolled complement activation. Although some of these disorders can be effectively treated with an antibody that inhibits complement C5, the high plasma concentration of C5 requires a huge dosage and f...

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Veröffentlicht in:	PloS one 2018-12, Vol.13 (12), p.e0209509-e0209509
Hauptverfasser:	Sampei, Zenjiro, Haraya, Kenta, Tachibana, Tatsuhiko, Fukuzawa, Taku, Shida-Kawazoe, Meiri, Gan, Siok Wan, Shimizu, Yuichiro, Ruike, Yoshinao, Feng, Shu, Kuramochi, Taichi, Muraoka, Masaru, Kitazawa, Takehisa, Kawabe, Yoshiki, Igawa, Tomoyuki, Hattori, Kunihiro, Nezu, Junichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Animals Antibodies Antibodies, Monoclonal - genetics Antibodies, Monoclonal - immunology Antibodies, Monoclonal - therapeutic use Antibody Affinity Antigens Binding Biology and Life Sciences Complement Complement (Immunology) Complement activation Complement Activation - drug effects Complement Activation - immunology Complement C5 - antagonists & inhibitors Complement C5 - immunology Complement C5 - isolation & purification Complement component C5 Complement system Computer Simulation Disorders Dosage Drug Discovery - methods Drug dosages Endosomes Endosomes - immunology Engineering Engineering and Technology Fc receptors Genetic aspects Hemophilia Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class I - immunology Humans Hydrogen-Ion Concentration Immune clearance Immune System Diseases - drug therapy Immune System Diseases - immunology Immunoglobulins Intravenous administration Macaca fascicularis Medicine and Health Sciences Mice Mice, Transgenic Monkeys Mutagenesis Mutation Neonates Neutralization pH effects Pharmaceuticals Physiological aspects Plasma Polymorphism Protein engineering Protein Engineering - methods Receptors, Fc - genetics Receptors, Fc - immunology Recombinant Proteins - immunology Recombinant Proteins - isolation & purification Recycling Salvage Surface charge Time Factors Viral antibodies
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