Live human assessment of depth-dependent corneal displacements with swept-source optical coherence elastography
To assess depth-dependent corneal displacements in live normal subjects using optical coherence elastography (OCE). A corneal elastography method based on swept-source optical coherence tomography (OCT) was implemented in a clinical prototype. Low amplitude corneal deformation was produced during OC...
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| creator | De Stefano, Vinicius S Ford, Matthew R Seven, Ibrahim Dupps, Jr, William J |
| description | To assess depth-dependent corneal displacements in live normal subjects using optical coherence elastography (OCE).
A corneal elastography method based on swept-source optical coherence tomography (OCT) was implemented in a clinical prototype. Low amplitude corneal deformation was produced during OCT imaging with a linear actuator-driven lens coupled to force transducers. A cross-correlation algorithm was applied to track frame-by-frame speckle displacement across horizontal meridian scans. Intra-measurement force and displacement data series were plotted against each other to produce local axial stiffness approximations, k, defined by the slope of a linear fit to the force/displacement data (ignoring non-axial contributions from corneal bending). Elastographic maps displaying local k values across the cornea were generated, and the ratio of mean axial stiffness approximations for adjacent anterior and posterior stromal regions, ka/kp, was calculated. Intraclass correlation coefficients (ICC) were used to estimate repeatability.
Seventeen eyes (ten subjects) were included in this prospective first-in-humans translational study. The ICC was 0.84. Graphs of force vs. displacement demonstrated that, for simultaneously acquired measurements involving the same applied force, anterior stromal displacements were lower (suggesting stiffer behavior) than posterior stromal displacements. Mean ka was 0.016±0.004 g/mm and mean kp was 0.014±0.004 g/mm, giving a mean ka/kp ratio of 1.123±0.062.
OCE is a clinically feasible, non-invasive corneal biomechanical characterization method capable of resolving depth-dependent differences in corneal deformation behavior. The anterior stroma demonstrated responses consistent with stiffer properties in compression than the posterior stroma, but to a degree that varied across normal eyes. The clinical capability to measure these differences has implications for assessing the biomechanical impact of corneal refractive surgeries and for ectasia risk screening applications. |
| doi_str_mv | 10.1371/journal.pone.0209480 |
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A corneal elastography method based on swept-source optical coherence tomography (OCT) was implemented in a clinical prototype. Low amplitude corneal deformation was produced during OCT imaging with a linear actuator-driven lens coupled to force transducers. A cross-correlation algorithm was applied to track frame-by-frame speckle displacement across horizontal meridian scans. Intra-measurement force and displacement data series were plotted against each other to produce local axial stiffness approximations, k, defined by the slope of a linear fit to the force/displacement data (ignoring non-axial contributions from corneal bending). Elastographic maps displaying local k values across the cornea were generated, and the ratio of mean axial stiffness approximations for adjacent anterior and posterior stromal regions, ka/kp, was calculated. Intraclass correlation coefficients (ICC) were used to estimate repeatability.
Seventeen eyes (ten subjects) were included in this prospective first-in-humans translational study. The ICC was 0.84. Graphs of force vs. displacement demonstrated that, for simultaneously acquired measurements involving the same applied force, anterior stromal displacements were lower (suggesting stiffer behavior) than posterior stromal displacements. Mean ka was 0.016±0.004 g/mm and mean kp was 0.014±0.004 g/mm, giving a mean ka/kp ratio of 1.123±0.062.
OCE is a clinically feasible, non-invasive corneal biomechanical characterization method capable of resolving depth-dependent differences in corneal deformation behavior. The anterior stroma demonstrated responses consistent with stiffer properties in compression than the posterior stroma, but to a degree that varied across normal eyes. The clinical capability to measure these differences has implications for assessing the biomechanical impact of corneal refractive surgeries and for ectasia risk screening applications.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0209480</identifier><identifier>PMID: 30592752</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Algorithms ; Biology and Life Sciences ; Biomechanics ; Care and treatment ; Cataracts ; Collagen ; Compression ; Cornea ; Cornea - diagnostic imaging ; Corneal diseases ; Corneal Diseases - diagnostic imaging ; Corneal Topography - methods ; Correlation ; Correlation coefficient ; Correlation coefficients ; Deformation ; Diagnosis ; Dilatation, Pathologic - diagnostic imaging ; Displacement ; Elasticity Imaging Techniques - methods ; Eye (anatomy) ; Feasibility Studies ; Female ; Healthy Volunteers ; Horizontal loads ; Human subjects ; Humans ; Male ; Measurement techniques ; Medical imaging ; Medicine and Health Sciences ; Middle Aged ; Optical Coherence Tomography ; Optical tomography ; Physical Sciences ; Prospective Studies ; Reproducibility of Results ; Research and Analysis Methods ; Social Sciences ; Stiffness ; Stroma ; Surgery ; Tensile strength ; Tomography ; Tomography, Optical Coherence - methods ; Transducers ; Ultrasonic imaging ; Young Adult</subject><ispartof>PloS one, 2018-12, Vol.13 (12), p.e0209480-e0209480</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 De Stefano et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 De Stefano et al 2018 De Stefano et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-3de21474ecf9ec1fb504abf5e4f021441f1704e354451900e835f40e8c54a8033</citedby><cites>FETCH-LOGICAL-c692t-3de21474ecf9ec1fb504abf5e4f021441f1704e354451900e835f40e8c54a8033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310362/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310362/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,2915,23847,27905,27906,53772,53774,79349,79350</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30592752$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Boote, Craig</contributor><creatorcontrib>De Stefano, Vinicius S</creatorcontrib><creatorcontrib>Ford, Matthew R</creatorcontrib><creatorcontrib>Seven, Ibrahim</creatorcontrib><creatorcontrib>Dupps, Jr, William J</creatorcontrib><title>Live human assessment of depth-dependent corneal displacements with swept-source optical coherence elastography</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To assess depth-dependent corneal displacements in live normal subjects using optical coherence elastography (OCE).
A corneal elastography method based on swept-source optical coherence tomography (OCT) was implemented in a clinical prototype. Low amplitude corneal deformation was produced during OCT imaging with a linear actuator-driven lens coupled to force transducers. A cross-correlation algorithm was applied to track frame-by-frame speckle displacement across horizontal meridian scans. Intra-measurement force and displacement data series were plotted against each other to produce local axial stiffness approximations, k, defined by the slope of a linear fit to the force/displacement data (ignoring non-axial contributions from corneal bending). Elastographic maps displaying local k values across the cornea were generated, and the ratio of mean axial stiffness approximations for adjacent anterior and posterior stromal regions, ka/kp, was calculated. Intraclass correlation coefficients (ICC) were used to estimate repeatability.
Seventeen eyes (ten subjects) were included in this prospective first-in-humans translational study. The ICC was 0.84. Graphs of force vs. displacement demonstrated that, for simultaneously acquired measurements involving the same applied force, anterior stromal displacements were lower (suggesting stiffer behavior) than posterior stromal displacements. Mean ka was 0.016±0.004 g/mm and mean kp was 0.014±0.004 g/mm, giving a mean ka/kp ratio of 1.123±0.062.
OCE is a clinically feasible, non-invasive corneal biomechanical characterization method capable of resolving depth-dependent differences in corneal deformation behavior. The anterior stroma demonstrated responses consistent with stiffer properties in compression than the posterior stroma, but to a degree that varied across normal eyes. The clinical capability to measure these differences has implications for assessing the biomechanical impact of corneal refractive surgeries and for ectasia risk screening applications.</description><subject>Adult</subject><subject>Algorithms</subject><subject>Biology and Life Sciences</subject><subject>Biomechanics</subject><subject>Care and treatment</subject><subject>Cataracts</subject><subject>Collagen</subject><subject>Compression</subject><subject>Cornea</subject><subject>Cornea - diagnostic imaging</subject><subject>Corneal diseases</subject><subject>Corneal Diseases - diagnostic imaging</subject><subject>Corneal Topography - methods</subject><subject>Correlation</subject><subject>Correlation coefficient</subject><subject>Correlation coefficients</subject><subject>Deformation</subject><subject>Diagnosis</subject><subject>Dilatation, Pathologic - diagnostic imaging</subject><subject>Displacement</subject><subject>Elasticity Imaging Techniques - methods</subject><subject>Eye (anatomy)</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Healthy Volunteers</subject><subject>Horizontal loads</subject><subject>Human subjects</subject><subject>Humans</subject><subject>Male</subject><subject>Measurement techniques</subject><subject>Medical imaging</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Optical Coherence Tomography</subject><subject>Optical tomography</subject><subject>Physical Sciences</subject><subject>Prospective Studies</subject><subject>Reproducibility of Results</subject><subject>Research and Analysis Methods</subject><subject>Social Sciences</subject><subject>Stiffness</subject><subject>Stroma</subject><subject>Surgery</subject><subject>Tensile strength</subject><subject>Tomography</subject><subject>Tomography, Optical Coherence - methods</subject><subject>Transducers</subject><subject>Ultrasonic imaging</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9tq3DAQhk1padK0b1BaQ6G0F97qaK9vCiH0sLAQ6OlWyPJ4rcW2XMlOmrfvOOuEdclFMVhi9M2vmdFMFL2kZEV5Rj_s3eg73ax618GKMJKLNXkUndKcsyRlhD8-2p9Ez0LYEyL5Ok2fRiecyJxlkp1GbmuvIK7HVnexDgFCaKEbYlfFJfRDneAfunIyGec70E1c2tA32sDEhfjaDnUcrpFNAgZkIHb9YA1yxtXgoUMLNDoMbud1X988j55UugnwYl7Pop-fP_24-JpsL79sLs63iUlzNiS8BEZFJsBUORhaFZIIXVQSREXwQNCKZkQAl0JImhMCay4rgYuRQq8J52fR64Nu37ig5loFxWhKWc5EJpHYHIjS6b3qvW21v1FOW3VrcH6ntMdUGlApy0iudUmIzkVeiIIYBpJIbXQGqIZaH-fbxqKF0mBpvG4WosuTztZq565UyinhKUOBd7OAd79HCINqbTDQNLoDNx7izvCR0ynuN_-gD2c3UzuNCdiucnivmUTVuUyzFBvgVmv1AIVfCa012FiVRfvC4f3CAZkB_gw7PYagNt-__T97-WvJvj1ia-yzoQ6uGQfrurAExQE03oXgobovMiVqmou7aqhpLtQ8F-j26viB7p3uBoH_BdtACUA</recordid><startdate>20181228</startdate><enddate>20181228</enddate><creator>De Stefano, Vinicius S</creator><creator>Ford, Matthew R</creator><creator>Seven, Ibrahim</creator><creator>Dupps, Jr, William J</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20181228</creationdate><title>Live human assessment of depth-dependent corneal displacements with swept-source optical coherence elastography</title><author>De Stefano, Vinicius S ; Ford, Matthew R ; Seven, Ibrahim ; Dupps, Jr, William J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-3de21474ecf9ec1fb504abf5e4f021441f1704e354451900e835f40e8c54a8033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Algorithms</topic><topic>Biology and Life Sciences</topic><topic>Biomechanics</topic><topic>Care and treatment</topic><topic>Cataracts</topic><topic>Collagen</topic><topic>Compression</topic><topic>Cornea</topic><topic>Cornea - diagnostic imaging</topic><topic>Corneal diseases</topic><topic>Corneal Diseases - diagnostic imaging</topic><topic>Corneal Topography - methods</topic><topic>Correlation</topic><topic>Correlation coefficient</topic><topic>Correlation coefficients</topic><topic>Deformation</topic><topic>Diagnosis</topic><topic>Dilatation, Pathologic - diagnostic imaging</topic><topic>Displacement</topic><topic>Elasticity Imaging Techniques - methods</topic><topic>Eye (anatomy)</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Healthy Volunteers</topic><topic>Horizontal loads</topic><topic>Human subjects</topic><topic>Humans</topic><topic>Male</topic><topic>Measurement techniques</topic><topic>Medical imaging</topic><topic>Medicine and Health Sciences</topic><topic>Middle Aged</topic><topic>Optical Coherence Tomography</topic><topic>Optical tomography</topic><topic>Physical Sciences</topic><topic>Prospective Studies</topic><topic>Reproducibility of Results</topic><topic>Research and Analysis Methods</topic><topic>Social Sciences</topic><topic>Stiffness</topic><topic>Stroma</topic><topic>Surgery</topic><topic>Tensile strength</topic><topic>Tomography</topic><topic>Tomography, Optical Coherence - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De Stefano, Vinicius S</au><au>Ford, Matthew R</au><au>Seven, Ibrahim</au><au>Dupps, Jr, William J</au><au>Boote, Craig</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Live human assessment of depth-dependent corneal displacements with swept-source optical coherence elastography</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2018-12-28</date><risdate>2018</risdate><volume>13</volume><issue>12</issue><spage>e0209480</spage><epage>e0209480</epage><pages>e0209480-e0209480</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To assess depth-dependent corneal displacements in live normal subjects using optical coherence elastography (OCE).
A corneal elastography method based on swept-source optical coherence tomography (OCT) was implemented in a clinical prototype. Low amplitude corneal deformation was produced during OCT imaging with a linear actuator-driven lens coupled to force transducers. A cross-correlation algorithm was applied to track frame-by-frame speckle displacement across horizontal meridian scans. Intra-measurement force and displacement data series were plotted against each other to produce local axial stiffness approximations, k, defined by the slope of a linear fit to the force/displacement data (ignoring non-axial contributions from corneal bending). Elastographic maps displaying local k values across the cornea were generated, and the ratio of mean axial stiffness approximations for adjacent anterior and posterior stromal regions, ka/kp, was calculated. Intraclass correlation coefficients (ICC) were used to estimate repeatability.
Seventeen eyes (ten subjects) were included in this prospective first-in-humans translational study. The ICC was 0.84. Graphs of force vs. displacement demonstrated that, for simultaneously acquired measurements involving the same applied force, anterior stromal displacements were lower (suggesting stiffer behavior) than posterior stromal displacements. Mean ka was 0.016±0.004 g/mm and mean kp was 0.014±0.004 g/mm, giving a mean ka/kp ratio of 1.123±0.062.
OCE is a clinically feasible, non-invasive corneal biomechanical characterization method capable of resolving depth-dependent differences in corneal deformation behavior. The anterior stroma demonstrated responses consistent with stiffer properties in compression than the posterior stroma, but to a degree that varied across normal eyes. The clinical capability to measure these differences has implications for assessing the biomechanical impact of corneal refractive surgeries and for ectasia risk screening applications.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>30592752</pmid><doi>10.1371/journal.pone.0209480</doi><tpages>e0209480</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Algorithms Biology and Life Sciences Biomechanics Care and treatment Cataracts Collagen Compression Cornea Cornea - diagnostic imaging Corneal diseases Corneal Diseases - diagnostic imaging Corneal Topography - methods Correlation Correlation coefficient Correlation coefficients Deformation Diagnosis Dilatation, Pathologic - diagnostic imaging Displacement Elasticity Imaging Techniques - methods Eye (anatomy) Feasibility Studies Female Healthy Volunteers Horizontal loads Human subjects Humans Male Measurement techniques Medical imaging Medicine and Health Sciences Middle Aged Optical Coherence Tomography Optical tomography Physical Sciences Prospective Studies Reproducibility of Results Research and Analysis Methods Social Sciences Stiffness Stroma Surgery Tensile strength Tomography Tomography, Optical Coherence - methods Transducers Ultrasonic imaging Young Adult |
| title | Live human assessment of depth-dependent corneal displacements with swept-source optical coherence elastography |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T13%3A53%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Live%20human%20assessment%20of%20depth-dependent%20corneal%20displacements%20with%20swept-source%20optical%20coherence%20elastography&rft.jtitle=PloS%20one&rft.au=De%20Stefano,%20Vinicius%20S&rft.date=2018-12-28&rft.volume=13&rft.issue=12&rft.spage=e0209480&rft.epage=e0209480&rft.pages=e0209480-e0209480&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0209480&rft_dat=%3Cgale_plos_%3EA567605965%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2161292475&rft_id=info:pmid/30592752&rft_galeid=A567605965&rft_doaj_id=oai_doaj_org_article_62709aad00a949b4b0c2e505aca7e924&rfr_iscdi=true |