Ischemia-reperfusion injury in a rat microvascular skin free flap model: A histological, genetic, and blood flow study

Ischemia reperfusion injury is associated with tissue damage and inflammation, and is one of the main factors causing flap failure in reconstructive microsurgery. Although ischemia-reperfusion (I/R) injury is a well-studied aspect of flap survival, its biological mechanisms remain to be elucidated....

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Veröffentlicht in:	PloS one 2018-12, Vol.13 (12), p.e0209624-e0209624
Hauptverfasser:	Ballestín, Alberto, Casado, Javier G, Abellán, Elena, Vela, F Javier, Álvarez, Verónica, Usón, Alejandra, López, Esther, Marinaro, Federica, Blázquez, Rebeca, Sánchez-Margallo, Francisco Miguel
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Angiogenesis Animals Apoptosis Arginase Biological activity Biology and Life Sciences Biomarkers Blood flow Care and treatment Chemical compounds Controlled conditions Cytokines Disease Models, Animal Edema Flaps Free Tissue Flaps - blood supply Gene expression Gene Expression Profiling Graft Survival Growth factors Hypoxia Immunohistochemistry Inflammation Injuries Injury analysis Injury prevention Ischemia Laparoscopy Male Medicine and Health Sciences Messenger RNA Microscopy Microsurgery Microvasculature Microvessels Nitric oxide Nitric-oxide synthase Pathological physiology Pharmacology Physiology Plastic surgery Rats Reperfusion Reperfusion injury Reperfusion Injury - etiology Reperfusion Injury - pathology Research and Analysis Methods Rodents Skin Skin Transplantation Stem cells Studies Surgery Survival Technology assessment Thoracic surgery Tissues Ultrasonic imaging Ultrasonography Ultrasound
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