Polycyclic aromatic hydrocarbons (PAHs) present in ambient urban dust drive proinflammatory T cell and dendritic cell responses via the aryl hydrocarbon receptor (AHR) in vitro

Atmospheric particulate matter (PM) is a complex component of air pollution that is a composed of inorganic and organic constituents. The chemically-extracted organic fraction (OF) of PM excludes inorganics but retains most organic constituents like polycyclic aromatic hydrocarbons (PAHs). PAHs are...

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Veröffentlicht in:	PloS one 2018-12, Vol.13 (12), p.e0209690
Hauptverfasser:	O'Driscoll, Chelsea A, Gallo, Madeline E, Hoffmann, Erica J, Fechner, John H, Schauer, James J, Bradfield, Christopher A, Mezrich, Joshua D
Format:	Artikel
Sprache:	eng
Schlagworte:	Air pollution Air pollution measurements Animals Aromatic compounds Atmospheric particulate matter Atmospheric pollution Biology and Life Sciences Biotransformation Bone Marrow Cells - drug effects Cell differentiation Cell Differentiation - drug effects Constituents Cytochrome Cytochrome P-450 CYP1A1 - genetics Cytochrome P450 Cytochromes - genetics Cytochromes P450 Dendritic cells Dendritic Cells - drug effects Differentiation (biology) Dust Enzymes Gene Expression Regulation - drug effects Helper cells Humans Immune system Inflammation Intermediates Ligands Lymphocyte Activation - drug effects Lymphocytes Lymphocytes T Medical research Medicine Medicine and Health Sciences Metabolism Mice Mice, Knockout Organic chemistry Organic constituents Outdoor air quality Particulate emissions Particulate matter Particulate Matter - toxicity Particulate matter in atmosphere Pollutants Polycyclic aromatic hydrocarbons Polycyclic Aromatic Hydrocarbons - chemistry Polycyclic Aromatic Hydrocarbons - classification Polycyclic Aromatic Hydrocarbons - toxicity Public health Receptors, Aryl Hydrocarbon - genetics Research and Analysis Methods Surgery T-Lymphocytes - drug effects Th17 Cells - drug effects Toxicants Toxicology Urban Health γ-Interferon
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