Prevalence, incidence and residual risk of transfusion-transmitted HBV infection before and after the implementation of HBV-NAT in northern Brazil
Nucleic acid testing (NAT) for virus detection during blood screening has helped to prevent transfusion-transmitted infections worldwide. In northern Brazil, NAT was implemented in 2012 for HIV and HCV and more recently, in January 2015, the screening for HBV was included and currently used concomit...
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| Veröffentlicht in: | PloS one 2018-12, Vol.13 (12), p.e0208414-e0208414 |
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| creator | Corrêa, Angelita Silva de Miranda Lamarão, Letícia Martins Vieira, Priscilla Cristina Moura de Castro, Renata Bezerra Hermes de Almeida, Núbia Caroline Costa de Castro, Jairo Augusto Américo de Lima, Maria Salete Maciel Palmeira, Mauricio Koury Meireles, Ana Luiza Langanke Pedroso Burbano, Rommel Rodríguez |
| description | Nucleic acid testing (NAT) for virus detection during blood screening has helped to prevent transfusion-transmitted infections worldwide. In northern Brazil, NAT was implemented in 2012 for HIV and HCV and more recently, in January 2015, the screening for HBV was included and currently used concomitant with serological tests (HBsAg and anti-HBc). This study aims to evaluate the prevalence and the incidence of HBV infection among voluntary blood donors at ten regional blood centers of HEMOPA Foundation in Pará state and to compare the residual risk of transfusion-transmitted HBV infection before and after the Brazilian HBV-NAT implementation.
The prevalence (restricted to first time donors- FT) and seroconversion rate (restricted to repeat donors- RP) of HBV were calculated based on rates of confirmed positive samples. Residual risk was based on the incidence and window period (WP) model described by Schreiber and coauthors. Logistic and Poisson regression were used in the statistical analysis by SPSS v20.0. A p value |
| doi_str_mv | 10.1371/journal.pone.0208414 |
| format | Article |
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The prevalence (restricted to first time donors- FT) and seroconversion rate (restricted to repeat donors- RP) of HBV were calculated based on rates of confirmed positive samples. Residual risk was based on the incidence and window period (WP) model described by Schreiber and coauthors. Logistic and Poisson regression were used in the statistical analysis by SPSS v20.0. A p value <0.05 was considered statistically significant.
HBV prevalence in the periods before and after the implementation of HBV-NAT were 247 and 251 per 100,000 donations, respectively. Seroconversion rates were 114 and 122 per 100,000 donations in the two periods, respectively. The residual risk (RR) for HBV decreased significantly in the posterior period to the HBV-NAT implementation, when compared to RR before implementation, with a reduction of 1:144,92 to 1:294,11 donations (p <0,001).
The RR to HBV decreased after the implementation of HBV-NAT, increasing significantly the transfusional security in the North region of Brazil at HEMOPA Foundation.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0208414</identifier><identifier>PMID: 30566494</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject><![CDATA[Acids ; Adolescent ; Adult ; Aged ; Antigens ; Biology and Life Sciences ; Blood ; Blood & organ donations ; Blood donors ; Blood Donors - statistics & numerical data ; Blood Safety - methods ; Blood Safety - standards ; Blood transfusion ; Blood transfusions ; Brazil - epidemiology ; Complications and side effects ; Cytogenetics ; Diagnosis ; DNA, Viral - analysis ; DNA, Viral - isolation & purification ; Female ; Guideline Adherence - statistics & numerical data ; Health Plan Implementation - standards ; Health risks ; Health screening ; Hematology ; Hepatitis ; Hepatitis B ; Hepatitis B - diagnosis ; Hepatitis B - epidemiology ; Hepatitis B - prevention & control ; Hepatitis B - transmission ; Hepatitis B surface antigen ; Hepatitis B virus - genetics ; Hepatitis B virus - isolation & purification ; HIV ; Human immunodeficiency virus ; Humans ; Incidence ; Infections ; Laboratories ; Male ; Mass Screening - methods ; Mass Screening - standards ; Medicine and Health Sciences ; Middle Aged ; Nucleic Acid Amplification Techniques - standards ; Nucleic acids ; People and places ; Poisson density functions ; Prevalence ; Prevention ; Public health ; Regression analysis ; Risk ; Risk Assessment ; Risk factors ; Screening ; Security ; Seroconversion ; Serologic Tests - methods ; Serologic Tests - standards ; Serological tests ; Social Sciences ; Statistical analysis ; Statistical methods ; Transfusion ; Transfusion Reaction - diagnosis ; Transfusion Reaction - epidemiology ; Transfusion Reaction - prevention & control ; Transfusion Reaction - virology ; Vaccines ; Viral infections ; Viruses ; Young Adult]]></subject><ispartof>PloS one, 2018-12, Vol.13 (12), p.e0208414-e0208414</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Corrêa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 Corrêa et al 2018 Corrêa et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-118cc0eb2b4c95d20b19d63f29e0c37c435e3aa5b2e34e51c9d0dbdf45bfaa413</citedby><cites>FETCH-LOGICAL-c692t-118cc0eb2b4c95d20b19d63f29e0c37c435e3aa5b2e34e51c9d0dbdf45bfaa413</cites><orcidid>0000-0002-6484-4988 ; 0000-0002-4872-234X ; 0000-0001-5952-4392</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300202/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300202/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30566494$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Corrêa, Angelita Silva de Miranda</creatorcontrib><creatorcontrib>Lamarão, Letícia Martins</creatorcontrib><creatorcontrib>Vieira, Priscilla Cristina Moura</creatorcontrib><creatorcontrib>de Castro, Renata Bezerra Hermes</creatorcontrib><creatorcontrib>de Almeida, Núbia Caroline Costa</creatorcontrib><creatorcontrib>de Castro, Jairo Augusto Américo</creatorcontrib><creatorcontrib>de Lima, Maria Salete Maciel</creatorcontrib><creatorcontrib>Palmeira, Mauricio Koury</creatorcontrib><creatorcontrib>Meireles, Ana Luiza Langanke Pedroso</creatorcontrib><creatorcontrib>Burbano, Rommel Rodríguez</creatorcontrib><title>Prevalence, incidence and residual risk of transfusion-transmitted HBV infection before and after the implementation of HBV-NAT in northern Brazil</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Nucleic acid testing (NAT) for virus detection during blood screening has helped to prevent transfusion-transmitted infections worldwide. In northern Brazil, NAT was implemented in 2012 for HIV and HCV and more recently, in January 2015, the screening for HBV was included and currently used concomitant with serological tests (HBsAg and anti-HBc). This study aims to evaluate the prevalence and the incidence of HBV infection among voluntary blood donors at ten regional blood centers of HEMOPA Foundation in Pará state and to compare the residual risk of transfusion-transmitted HBV infection before and after the Brazilian HBV-NAT implementation.
The prevalence (restricted to first time donors- FT) and seroconversion rate (restricted to repeat donors- RP) of HBV were calculated based on rates of confirmed positive samples. Residual risk was based on the incidence and window period (WP) model described by Schreiber and coauthors. Logistic and Poisson regression were used in the statistical analysis by SPSS v20.0. A p value <0.05 was considered statistically significant.
HBV prevalence in the periods before and after the implementation of HBV-NAT were 247 and 251 per 100,000 donations, respectively. Seroconversion rates were 114 and 122 per 100,000 donations in the two periods, respectively. The residual risk (RR) for HBV decreased significantly in the posterior period to the HBV-NAT implementation, when compared to RR before implementation, with a reduction of 1:144,92 to 1:294,11 donations (p <0,001).
The RR to HBV decreased after the implementation of HBV-NAT, increasing significantly the transfusional security in the North region of Brazil at HEMOPA Foundation.</description><subject>Acids</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Antigens</subject><subject>Biology and Life Sciences</subject><subject>Blood</subject><subject>Blood & organ donations</subject><subject>Blood donors</subject><subject>Blood Donors - statistics & numerical data</subject><subject>Blood Safety - methods</subject><subject>Blood Safety - standards</subject><subject>Blood transfusion</subject><subject>Blood transfusions</subject><subject>Brazil - epidemiology</subject><subject>Complications and side effects</subject><subject>Cytogenetics</subject><subject>Diagnosis</subject><subject>DNA, Viral - analysis</subject><subject>DNA, Viral - isolation & purification</subject><subject>Female</subject><subject>Guideline Adherence - statistics & numerical data</subject><subject>Health Plan Implementation - standards</subject><subject>Health risks</subject><subject>Health screening</subject><subject>Hematology</subject><subject>Hepatitis</subject><subject>Hepatitis B</subject><subject>Hepatitis B - diagnosis</subject><subject>Hepatitis B - epidemiology</subject><subject>Hepatitis B - prevention & control</subject><subject>Hepatitis B - transmission</subject><subject>Hepatitis B surface antigen</subject><subject>Hepatitis B virus - genetics</subject><subject>Hepatitis B virus - isolation & purification</subject><subject>HIV</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infections</subject><subject>Laboratories</subject><subject>Male</subject><subject>Mass Screening - methods</subject><subject>Mass Screening - standards</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Nucleic Acid Amplification Techniques - standards</subject><subject>Nucleic acids</subject><subject>People and places</subject><subject>Poisson density functions</subject><subject>Prevalence</subject><subject>Prevention</subject><subject>Public health</subject><subject>Regression analysis</subject><subject>Risk</subject><subject>Risk Assessment</subject><subject>Risk factors</subject><subject>Screening</subject><subject>Security</subject><subject>Seroconversion</subject><subject>Serologic Tests - methods</subject><subject>Serologic Tests - standards</subject><subject>Serological tests</subject><subject>Social Sciences</subject><subject>Statistical analysis</subject><subject>Statistical methods</subject><subject>Transfusion</subject><subject>Transfusion Reaction - diagnosis</subject><subject>Transfusion Reaction - epidemiology</subject><subject>Transfusion Reaction - prevention & control</subject><subject>Transfusion Reaction - virology</subject><subject>Vaccines</subject><subject>Viral infections</subject><subject>Viruses</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk99u0zAUxiMEYmPwBggiISGQSLFjJ01ukLoJWKWJIRi7tU6ck9bDiYvtTMBj8MQ4bTY1aBcoFzmyf99n-_yJoqeUzCib07dXprcd6NnGdDgjKSk45feiQ1qyNMlTwu7vxQfRI-euCMlYkecPowNGsjznJT-M_ny2eA0aO4lvYtVJVQ9hDF0dW3Sq7kHHVrnvsWlib6FzTe-U6ZJt3CrvsY5Pjy-DtEHpw05cYWPszgEajzb2a4xVu9HYYudhywSzIEo-LS6CMO6MDYzt4mMLv5V-HD1oQDt8Mv6Pom8f3l-cnCZn5x-XJ4uzROZl6hNKCykJVmnFZZnVKaloWeesSUskks0lZxkygKxKkXHMqCxrUld1w7OqAeCUHUXPd74bbZwY0-lESrMiy2hRDsRyR9QGrsTGqhbsL2FAie2CsSsB1iupUZQEqoIRmJO84kjzEjEDXuVFAwUUsgxe78bT-qrFWoZcWNAT0-lOp9ZiZa5FzkiobhoMXo0G1vzo0XnRKidRa-jQ9Nt7h3LTlAz3fvEPevfrRmoV6i9CAU04Vw6mYhHag_F5RvJAze6gwldjq2TovUaF9Yng9UQQGI8__Qp658Ty65f_Z88vp-zLPXaNoP3aGd0PDeWmIN-B0hrnLDa3SaZEDKNzkw0xjI4YRyfInu0X6FZ0MyvsL99EFeY</recordid><startdate>20181219</startdate><enddate>20181219</enddate><creator>Corrêa, Angelita Silva de Miranda</creator><creator>Lamarão, Letícia Martins</creator><creator>Vieira, Priscilla Cristina Moura</creator><creator>de Castro, Renata Bezerra Hermes</creator><creator>de Almeida, Núbia Caroline Costa</creator><creator>de Castro, Jairo Augusto Américo</creator><creator>de Lima, Maria Salete Maciel</creator><creator>Palmeira, Mauricio Koury</creator><creator>Meireles, Ana Luiza Langanke Pedroso</creator><creator>Burbano, Rommel Rodríguez</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-6484-4988</orcidid><orcidid>https://orcid.org/0000-0002-4872-234X</orcidid><orcidid>https://orcid.org/0000-0001-5952-4392</orcidid></search><sort><creationdate>20181219</creationdate><title>Prevalence, incidence and residual risk of transfusion-transmitted HBV infection before and after the implementation of HBV-NAT in northern Brazil</title><author>Corrêa, Angelita Silva de Miranda ; Lamarão, Letícia Martins ; Vieira, Priscilla Cristina Moura ; de Castro, Renata Bezerra Hermes ; de Almeida, Núbia Caroline Costa ; de Castro, Jairo Augusto Américo ; de Lima, Maria Salete Maciel ; Palmeira, Mauricio Koury ; Meireles, Ana Luiza Langanke Pedroso ; Burbano, Rommel Rodríguez</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-118cc0eb2b4c95d20b19d63f29e0c37c435e3aa5b2e34e51c9d0dbdf45bfaa413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Acids</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Antigens</topic><topic>Biology and Life Sciences</topic><topic>Blood</topic><topic>Blood & organ donations</topic><topic>Blood donors</topic><topic>Blood Donors - 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methods</topic><topic>Mass Screening - standards</topic><topic>Medicine and Health Sciences</topic><topic>Middle Aged</topic><topic>Nucleic Acid Amplification Techniques - standards</topic><topic>Nucleic acids</topic><topic>People and places</topic><topic>Poisson density functions</topic><topic>Prevalence</topic><topic>Prevention</topic><topic>Public health</topic><topic>Regression analysis</topic><topic>Risk</topic><topic>Risk Assessment</topic><topic>Risk factors</topic><topic>Screening</topic><topic>Security</topic><topic>Seroconversion</topic><topic>Serologic Tests - methods</topic><topic>Serologic Tests - standards</topic><topic>Serological tests</topic><topic>Social Sciences</topic><topic>Statistical analysis</topic><topic>Statistical methods</topic><topic>Transfusion</topic><topic>Transfusion Reaction - diagnosis</topic><topic>Transfusion Reaction - epidemiology</topic><topic>Transfusion Reaction - prevention & control</topic><topic>Transfusion Reaction - virology</topic><topic>Vaccines</topic><topic>Viral infections</topic><topic>Viruses</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Corrêa, Angelita Silva de Miranda</creatorcontrib><creatorcontrib>Lamarão, Letícia Martins</creatorcontrib><creatorcontrib>Vieira, Priscilla Cristina Moura</creatorcontrib><creatorcontrib>de Castro, Renata Bezerra Hermes</creatorcontrib><creatorcontrib>de Almeida, Núbia Caroline Costa</creatorcontrib><creatorcontrib>de Castro, Jairo Augusto Américo</creatorcontrib><creatorcontrib>de Lima, Maria Salete Maciel</creatorcontrib><creatorcontrib>Palmeira, Mauricio Koury</creatorcontrib><creatorcontrib>Meireles, Ana Luiza Langanke Pedroso</creatorcontrib><creatorcontrib>Burbano, Rommel Rodríguez</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Corrêa, Angelita Silva de Miranda</au><au>Lamarão, Letícia Martins</au><au>Vieira, Priscilla Cristina Moura</au><au>de Castro, Renata Bezerra Hermes</au><au>de Almeida, Núbia Caroline Costa</au><au>de Castro, Jairo Augusto Américo</au><au>de Lima, Maria Salete Maciel</au><au>Palmeira, Mauricio Koury</au><au>Meireles, Ana Luiza Langanke Pedroso</au><au>Burbano, Rommel Rodríguez</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence, incidence and residual risk of transfusion-transmitted HBV infection before and after the implementation of HBV-NAT in northern Brazil</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2018-12-19</date><risdate>2018</risdate><volume>13</volume><issue>12</issue><spage>e0208414</spage><epage>e0208414</epage><pages>e0208414-e0208414</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Nucleic acid testing (NAT) for virus detection during blood screening has helped to prevent transfusion-transmitted infections worldwide. In northern Brazil, NAT was implemented in 2012 for HIV and HCV and more recently, in January 2015, the screening for HBV was included and currently used concomitant with serological tests (HBsAg and anti-HBc). This study aims to evaluate the prevalence and the incidence of HBV infection among voluntary blood donors at ten regional blood centers of HEMOPA Foundation in Pará state and to compare the residual risk of transfusion-transmitted HBV infection before and after the Brazilian HBV-NAT implementation.
The prevalence (restricted to first time donors- FT) and seroconversion rate (restricted to repeat donors- RP) of HBV were calculated based on rates of confirmed positive samples. Residual risk was based on the incidence and window period (WP) model described by Schreiber and coauthors. Logistic and Poisson regression were used in the statistical analysis by SPSS v20.0. A p value <0.05 was considered statistically significant.
HBV prevalence in the periods before and after the implementation of HBV-NAT were 247 and 251 per 100,000 donations, respectively. Seroconversion rates were 114 and 122 per 100,000 donations in the two periods, respectively. The residual risk (RR) for HBV decreased significantly in the posterior period to the HBV-NAT implementation, when compared to RR before implementation, with a reduction of 1:144,92 to 1:294,11 donations (p <0,001).
The RR to HBV decreased after the implementation of HBV-NAT, increasing significantly the transfusional security in the North region of Brazil at HEMOPA Foundation.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>30566494</pmid><doi>10.1371/journal.pone.0208414</doi><tpages>e0208414</tpages><orcidid>https://orcid.org/0000-0002-6484-4988</orcidid><orcidid>https://orcid.org/0000-0002-4872-234X</orcidid><orcidid>https://orcid.org/0000-0001-5952-4392</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2018-12, Vol.13 (12), p.e0208414-e0208414 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2158551891 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Acids Adolescent Adult Aged Antigens Biology and Life Sciences Blood Blood & organ donations Blood donors Blood Donors - statistics & numerical data Blood Safety - methods Blood Safety - standards Blood transfusion Blood transfusions Brazil - epidemiology Complications and side effects Cytogenetics Diagnosis DNA, Viral - analysis DNA, Viral - isolation & purification Female Guideline Adherence - statistics & numerical data Health Plan Implementation - standards Health risks Health screening Hematology Hepatitis Hepatitis B Hepatitis B - diagnosis Hepatitis B - epidemiology Hepatitis B - prevention & control Hepatitis B - transmission Hepatitis B surface antigen Hepatitis B virus - genetics Hepatitis B virus - isolation & purification HIV Human immunodeficiency virus Humans Incidence Infections Laboratories Male Mass Screening - methods Mass Screening - standards Medicine and Health Sciences Middle Aged Nucleic Acid Amplification Techniques - standards Nucleic acids People and places Poisson density functions Prevalence Prevention Public health Regression analysis Risk Risk Assessment Risk factors Screening Security Seroconversion Serologic Tests - methods Serologic Tests - standards Serological tests Social Sciences Statistical analysis Statistical methods Transfusion Transfusion Reaction - diagnosis Transfusion Reaction - epidemiology Transfusion Reaction - prevention & control Transfusion Reaction - virology Vaccines Viral infections Viruses Young Adult |
| title | Prevalence, incidence and residual risk of transfusion-transmitted HBV infection before and after the implementation of HBV-NAT in northern Brazil |
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