Functional evaluation outcomes correlate with histomorphometric changes in the rat sciatic nerve crush injury model: A comparison between sciatic functional index and kinematic analysis
Elucidating whether there is a correlation between biomechanical functions and histomorphometric data in the rat sciatic nerve crush injury model would contribute to an accurate evaluation of the regeneration state without sacrificing animals. The gold standard for functional evaluation is the sciat...
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| creator | Wang, Tianshu Ito, Akira Aoyama, Tomoki Nakahara, Ryo Nakahata, Akihiro Ji, Xiang Zhang, Jue Kawai, Hideki Kuroki, Hiroshi |
| description | Elucidating whether there is a correlation between biomechanical functions and histomorphometric data in the rat sciatic nerve crush injury model would contribute to an accurate evaluation of the regeneration state without sacrificing animals. The gold standard for functional evaluation is the sciatic functional index (SFI) despite there being intrinsic shortcomings. Kinematic analysis is considered a reliable and sensitive approach for functional evaluation, most commonly assessed as ankle angle at various phases of a gait cycle. Studies utilizing the toe angle for functional evaluation are scarce, and changes in the toe angle following surgery remain unknown. The present study assessed correlations of ankle angle, toe angle and SFI with histomorphometric data, aiming to determine which parameters most accurately reflect changes in histomorphometric data over time. Six Lewis rats were designated as the control group. 30 animals received surgery, six of them were randomly selected on the first, second, third, fourth, and sixth week after surgery for measurements of ankle and toe angles in the "toe-off" phase, and for evaluation of SFI. Histomorphometric analysis were also performed, to determine the number of myelinated nerve fibers, diameters of myelinated nerve fibers, axon diameters, and myelin sheath thicknesses. Furthermore, we investigated changes in ankle angle, toe angle, SFI, and histomorphometric data over time, as well as correlations between ankle angle, toe angle, and SFI with histomorphometric data. The results revealed that changes in SFI, ankle angle, and toe angle highly correlate with histomorphometric data in the rat sciatic nerve crush injury model. Toe angle reflected changes in histomorphometric data with time more precisely than ankle angle or SFI did, and ankle angle was a better prognostic parameter than SFI. |
| doi_str_mv | 10.1371/journal.pone.0208985 |
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The gold standard for functional evaluation is the sciatic functional index (SFI) despite there being intrinsic shortcomings. Kinematic analysis is considered a reliable and sensitive approach for functional evaluation, most commonly assessed as ankle angle at various phases of a gait cycle. Studies utilizing the toe angle for functional evaluation are scarce, and changes in the toe angle following surgery remain unknown. The present study assessed correlations of ankle angle, toe angle and SFI with histomorphometric data, aiming to determine which parameters most accurately reflect changes in histomorphometric data over time. Six Lewis rats were designated as the control group. 30 animals received surgery, six of them were randomly selected on the first, second, third, fourth, and sixth week after surgery for measurements of ankle and toe angles in the "toe-off" phase, and for evaluation of SFI. Histomorphometric analysis were also performed, to determine the number of myelinated nerve fibers, diameters of myelinated nerve fibers, axon diameters, and myelin sheath thicknesses. Furthermore, we investigated changes in ankle angle, toe angle, SFI, and histomorphometric data over time, as well as correlations between ankle angle, toe angle, and SFI with histomorphometric data. The results revealed that changes in SFI, ankle angle, and toe angle highly correlate with histomorphometric data in the rat sciatic nerve crush injury model. Toe angle reflected changes in histomorphometric data with time more precisely than ankle angle or SFI did, and ankle angle was a better prognostic parameter than SFI.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0208985</identifier><identifier>PMID: 30540822</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animals ; Ankle ; Axons - physiology ; Biology and Life Sciences ; Biomechanical engineering ; Biomechanical Phenomena ; Biomechanics ; Correlation ; Correlation analysis ; Crush tests ; Disease Models, Animal ; Evaluation ; Fibers ; Gait ; Health sciences ; Injuries ; Injury analysis ; Kinematics ; Male ; Mathematical models ; Medicine ; Medicine and Health Sciences ; Methods ; Microsurgery ; Myelin ; Myelin Sheath - pathology ; Myelin Sheath - physiology ; Nerve Fibers, Myelinated - pathology ; Nerve Fibers, Myelinated - physiology ; Parameters ; Physical Sciences ; Rats ; Rats, Inbred Lew ; Recovery of Function ; Regeneration ; Rehabilitation ; Sciatic nerve ; Sciatic Nerve - injuries ; Sciatic Nerve - pathology ; Sheaths ; Surgery ; Tarsus, Animal - pathology ; Tarsus, Animal - physiology ; Toe ; Toes - physiology ; Ultrasonic imaging ; Walking</subject><ispartof>PloS one, 2018-12, Vol.13 (12), p.e0208985-e0208985</ispartof><rights>2018 Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 Wang et al 2018 Wang et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c636t-ac6cd0edda885e71072494d00b4640707710622c5a58d14c49493b2d8643bddd3</citedby><orcidid>0000-0002-9645-9777</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291147/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291147/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30540822$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Tianshu</creatorcontrib><creatorcontrib>Ito, Akira</creatorcontrib><creatorcontrib>Aoyama, Tomoki</creatorcontrib><creatorcontrib>Nakahara, Ryo</creatorcontrib><creatorcontrib>Nakahata, Akihiro</creatorcontrib><creatorcontrib>Ji, Xiang</creatorcontrib><creatorcontrib>Zhang, Jue</creatorcontrib><creatorcontrib>Kawai, Hideki</creatorcontrib><creatorcontrib>Kuroki, Hiroshi</creatorcontrib><title>Functional evaluation outcomes correlate with histomorphometric changes in the rat sciatic nerve crush injury model: A comparison between sciatic functional index and kinematic analysis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Elucidating whether there is a correlation between biomechanical functions and histomorphometric data in the rat sciatic nerve crush injury model would contribute to an accurate evaluation of the regeneration state without sacrificing animals. The gold standard for functional evaluation is the sciatic functional index (SFI) despite there being intrinsic shortcomings. Kinematic analysis is considered a reliable and sensitive approach for functional evaluation, most commonly assessed as ankle angle at various phases of a gait cycle. Studies utilizing the toe angle for functional evaluation are scarce, and changes in the toe angle following surgery remain unknown. The present study assessed correlations of ankle angle, toe angle and SFI with histomorphometric data, aiming to determine which parameters most accurately reflect changes in histomorphometric data over time. Six Lewis rats were designated as the control group. 30 animals received surgery, six of them were randomly selected on the first, second, third, fourth, and sixth week after surgery for measurements of ankle and toe angles in the "toe-off" phase, and for evaluation of SFI. Histomorphometric analysis were also performed, to determine the number of myelinated nerve fibers, diameters of myelinated nerve fibers, axon diameters, and myelin sheath thicknesses. Furthermore, we investigated changes in ankle angle, toe angle, SFI, and histomorphometric data over time, as well as correlations between ankle angle, toe angle, and SFI with histomorphometric data. The results revealed that changes in SFI, ankle angle, and toe angle highly correlate with histomorphometric data in the rat sciatic nerve crush injury model. Toe angle reflected changes in histomorphometric data with time more precisely than ankle angle or SFI did, and ankle angle was a better prognostic parameter than SFI.</description><subject>Animals</subject><subject>Ankle</subject><subject>Axons - physiology</subject><subject>Biology and Life Sciences</subject><subject>Biomechanical engineering</subject><subject>Biomechanical Phenomena</subject><subject>Biomechanics</subject><subject>Correlation</subject><subject>Correlation analysis</subject><subject>Crush tests</subject><subject>Disease Models, Animal</subject><subject>Evaluation</subject><subject>Fibers</subject><subject>Gait</subject><subject>Health sciences</subject><subject>Injuries</subject><subject>Injury analysis</subject><subject>Kinematics</subject><subject>Male</subject><subject>Mathematical models</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Methods</subject><subject>Microsurgery</subject><subject>Myelin</subject><subject>Myelin Sheath - pathology</subject><subject>Myelin Sheath - physiology</subject><subject>Nerve Fibers, Myelinated - pathology</subject><subject>Nerve Fibers, Myelinated - physiology</subject><subject>Parameters</subject><subject>Physical Sciences</subject><subject>Rats</subject><subject>Rats, Inbred Lew</subject><subject>Recovery of Function</subject><subject>Regeneration</subject><subject>Rehabilitation</subject><subject>Sciatic nerve</subject><subject>Sciatic Nerve - injuries</subject><subject>Sciatic Nerve - pathology</subject><subject>Sheaths</subject><subject>Surgery</subject><subject>Tarsus, Animal - pathology</subject><subject>Tarsus, Animal - physiology</subject><subject>Toe</subject><subject>Toes - physiology</subject><subject>Ultrasonic imaging</subject><subject>Walking</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNptUk1v1DAQjRCIlsI_QGCJC5dd_JE4CYdKVUWhUiUucLYce7Lx4tiL7WzZn8a_w9tNlxZxsj3vzZs34ymK1wQvCavJh7WfgpN2ufEOlpjipm2qJ8UpaRldcIrZ0wf3k-JFjGuMK9Zw_rw4YbgqcUPpafH7anIqGZ-VEGylneT-gfyUlB8hIuVDACsToFuTBjSYmPzow2bIaApGITVIt8pE41AaAAWZUFQmqyjkIGwBqTDFIcPrKezQ6DXYj-gi644bGUzMtTpItwDumNb_dWSchl9IOo1-GAfjHSwzsIsmviye9dJGeDWfZ8X3q0_fLr8sbr5-vr68uFkoznhaSMWVxqC1bJoKaoJrWralxrgreYlrXOcQp1RVsmo0KVUGW9ZR3fCSdVprdla8PehurI9innoUlFQVYbhmdWZcHxjay7XYBDPKsBNeGnEX8GElZMjWLQjoCVVZF_L0S6X7VtMeFKVdVZP8NSxrnc_Vpm4ErcClIO0j0ceIM4NY-a3gtCWk3Jt5PwsE_3OCmMRoogJrpQM_HXw3bcvbJlPf_UP9f3flgaWCjzFAfzRDsNhv4n2W2G-imDcxp7152Mgx6X712B_GF-IZ</recordid><startdate>20181212</startdate><enddate>20181212</enddate><creator>Wang, Tianshu</creator><creator>Ito, Akira</creator><creator>Aoyama, Tomoki</creator><creator>Nakahara, Ryo</creator><creator>Nakahata, Akihiro</creator><creator>Ji, Xiang</creator><creator>Zhang, Jue</creator><creator>Kawai, Hideki</creator><creator>Kuroki, Hiroshi</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-9645-9777</orcidid></search><sort><creationdate>20181212</creationdate><title>Functional evaluation outcomes correlate with histomorphometric changes in the rat sciatic nerve crush injury model: A comparison between sciatic functional index and kinematic analysis</title><author>Wang, Tianshu ; Ito, Akira ; Aoyama, Tomoki ; Nakahara, Ryo ; Nakahata, Akihiro ; Ji, Xiang ; Zhang, Jue ; Kawai, Hideki ; Kuroki, Hiroshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c636t-ac6cd0edda885e71072494d00b4640707710622c5a58d14c49493b2d8643bddd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Ankle</topic><topic>Axons - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Tianshu</au><au>Ito, Akira</au><au>Aoyama, Tomoki</au><au>Nakahara, Ryo</au><au>Nakahata, Akihiro</au><au>Ji, Xiang</au><au>Zhang, Jue</au><au>Kawai, Hideki</au><au>Kuroki, Hiroshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional evaluation outcomes correlate with histomorphometric changes in the rat sciatic nerve crush injury model: A comparison between sciatic functional index and kinematic analysis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2018-12-12</date><risdate>2018</risdate><volume>13</volume><issue>12</issue><spage>e0208985</spage><epage>e0208985</epage><pages>e0208985-e0208985</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Elucidating whether there is a correlation between biomechanical functions and histomorphometric data in the rat sciatic nerve crush injury model would contribute to an accurate evaluation of the regeneration state without sacrificing animals. The gold standard for functional evaluation is the sciatic functional index (SFI) despite there being intrinsic shortcomings. Kinematic analysis is considered a reliable and sensitive approach for functional evaluation, most commonly assessed as ankle angle at various phases of a gait cycle. Studies utilizing the toe angle for functional evaluation are scarce, and changes in the toe angle following surgery remain unknown. The present study assessed correlations of ankle angle, toe angle and SFI with histomorphometric data, aiming to determine which parameters most accurately reflect changes in histomorphometric data over time. Six Lewis rats were designated as the control group. 30 animals received surgery, six of them were randomly selected on the first, second, third, fourth, and sixth week after surgery for measurements of ankle and toe angles in the "toe-off" phase, and for evaluation of SFI. Histomorphometric analysis were also performed, to determine the number of myelinated nerve fibers, diameters of myelinated nerve fibers, axon diameters, and myelin sheath thicknesses. Furthermore, we investigated changes in ankle angle, toe angle, SFI, and histomorphometric data over time, as well as correlations between ankle angle, toe angle, and SFI with histomorphometric data. The results revealed that changes in SFI, ankle angle, and toe angle highly correlate with histomorphometric data in the rat sciatic nerve crush injury model. Toe angle reflected changes in histomorphometric data with time more precisely than ankle angle or SFI did, and ankle angle was a better prognostic parameter than SFI.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>30540822</pmid><doi>10.1371/journal.pone.0208985</doi><orcidid>https://orcid.org/0000-0002-9645-9777</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Animals Ankle Axons - physiology Biology and Life Sciences Biomechanical engineering Biomechanical Phenomena Biomechanics Correlation Correlation analysis Crush tests Disease Models, Animal Evaluation Fibers Gait Health sciences Injuries Injury analysis Kinematics Male Mathematical models Medicine Medicine and Health Sciences Methods Microsurgery Myelin Myelin Sheath - pathology Myelin Sheath - physiology Nerve Fibers, Myelinated - pathology Nerve Fibers, Myelinated - physiology Parameters Physical Sciences Rats Rats, Inbred Lew Recovery of Function Regeneration Rehabilitation Sciatic nerve Sciatic Nerve - injuries Sciatic Nerve - pathology Sheaths Surgery Tarsus, Animal - pathology Tarsus, Animal - physiology Toe Toes - physiology Ultrasonic imaging Walking |
| title | Functional evaluation outcomes correlate with histomorphometric changes in the rat sciatic nerve crush injury model: A comparison between sciatic functional index and kinematic analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T16%3A05%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Functional%20evaluation%20outcomes%20correlate%20with%20histomorphometric%20changes%20in%20the%20rat%20sciatic%20nerve%20crush%20injury%20model:%20A%20comparison%20between%20sciatic%20functional%20index%20and%20kinematic%20analysis&rft.jtitle=PloS%20one&rft.au=Wang,%20Tianshu&rft.date=2018-12-12&rft.volume=13&rft.issue=12&rft.spage=e0208985&rft.epage=e0208985&rft.pages=e0208985-e0208985&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0208985&rft_dat=%3Cproquest_plos_%3E2155130737%3C/proquest_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2155130737&rft_id=info:pmid/30540822&rft_doaj_id=oai_doaj_org_article_ef12c3bde0824cdf9d2fec22b5718663&rfr_iscdi=true |