Evaluation of an outbred mouse model for Francisella tularensis vaccine development and testing

Francisella tularensis (Ft) is a biothreat agent for which there is no FDA-approved human vaccine. Currently, there are substantial efforts underway to develop both vaccines and the tools to assess these vaccines. Tularemia laboratory research has historically relied primarily upon a small number of...

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Veröffentlicht in:	PloS one 2018-12, Vol.13 (12), p.e0207587-e0207587
Hauptverfasser:	Sunagar, Raju, Kumar, Sudeep, Namjoshi, Prachi, Rosa, Sarah J, Hazlett, Karsten R O, Gosselin, Edmund J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Antigens, Bacterial - immunology Bacterial Proteins - genetics Bacterial Vaccines - immunology Biology and Life Sciences CD4 antigen CD4-Positive T-Lymphocytes - immunology CD8 antigen CD8-Positive T-Lymphocytes - immunology Cytokines Cytokines - metabolism Disease susceptibility Drug approval Female Francisella tularensis Francisella tularensis - genetics Francisella tularensis - immunology Francisella tularensis - physiology Historical account House mouse Human populations Immunology Inbreeding Infection Infections Inflammation Laboratories Laboratory rats Lymphocytes Lymphocytes T Major histocompatibility complex Male Medical research Medicine and Health Sciences Mice Mice, Inbred C57BL Model testing Mucosa Mutation Neutralization Pathogens Pathology Physiological aspects Research and Analysis Methods Respiration Rodents Superoxide dismutase Superoxide Dismutase - genetics Superoxides T cells Th1 Cells - immunology Th1 Cells - metabolism Th17 Cells - immunology Th17 Cells - metabolism Tularemia Vaccination Vaccine development Vaccines γ-Interferon
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