Metformin and insulin treatment prevent placental telomere attrition in boys exposed to maternal diabetes

Shortened leukocyte and placental telomeres associated with gestational diabetes mellitus (GDM) suggest this exposure triggers telomere attrition contributing to adverse outcomes. We applied high resolution Single Telomere Length Analysis (STELA) to placenta from GDM pregnancies with different treat...

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Veröffentlicht in:	PloS one 2018-12, Vol.13 (12), p.e0208533-e0208533
Hauptverfasser:	Garcia-Martin, Isabel, Penketh, Richard J A, Janssen, Anna B, Jones, Rhiannon E, Grimstead, Julia, Baird, Duncan M, John, Rosalind M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aging Analysis of Variance Antidiabetics Biology and Life Sciences Cancer Case-Control Studies Cell division Children Chromosomes Covariance Deoxyribonucleic acid Diabetes Diabetes mellitus Diabetes therapy Diabetes, Gestational - drug therapy DNA Dosage and administration Drug therapy Ethics Female Fetuses Genetics Gestational diabetes Health aspects Health risk assessment Humans Hypoglycemic agents Hypoglycemic Agents - therapeutic use Insulin Insulin - therapeutic use Insulin resistance Intervention Leukocytes Male Medical treatment Medicine and Health Sciences Metformin Metformin - therapeutic use Obesity Placenta Placenta - metabolism Pregnancy Risk Reduction Behavior Studies Telomerase Telomere - chemistry Telomere - metabolism Telomere Shortening Telomeres Type 2 diabetes
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