$Thiazide-associated hyponatremia attenuates the fracture-protective effect of thiazide: A population-based study$

Thiazide-associated hyponatremia attenuates the fracture-protective effect of thiazide: A population-based study

Thiazide, a first-line therapy for hypertension, lowers blood pressure, increases bone mineral density, and reduces the risk of fractures. However, hyponatremia, an adverse effect of thiazide, is associated with increased risk of osteoporosis and fractures. It is currently unclear whether thiazide-a...

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Veröffentlicht in:	PloS one 2018-12, Vol.13 (12), p.e0208712-e0208712
Hauptverfasser:	Yang, Lii-Jia, Wu, Ping-Hsun, Huang, Teng-Hui, Lin, Ming-Yen, Tsai, Jer-Chia
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antihypertensive Agents - adverse effects Antihypertensive Agents - therapeutic use Biocompatibility Biology and Life Sciences Biomedical materials Blood pressure Bone density Bone mineral density Comorbidity Complications and side effects Confidence intervals Diagnosis Diuretics Dosage and administration Drug therapy Female Fractures Fractures (Injuries) Fractures, Bone - epidemiology Fractures, Bone - prevention & control Health risk assessment Heart failure Hip Hip fractures Humans Hypertension Hypertension - drug therapy Hypertension - epidemiology Hyponatremia Hyponatremia - epidemiology Hyponatremia - etiology Incidence Insurance Longitudinal Studies Male Medical research Medicine and Health Sciences Middle Aged National health insurance Nonsteroidal anti-inflammatory drugs Online databases Osteoporosis Patients Population studies Population-based studies Regression analysis Regression models Risk Risk Factors Spine Statistical analysis Thiazides Thiazides - adverse effects Thiazides - therapeutic use Vertebrae
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