Comparison of efficacy of SHENQI compound and rosiglitazone in the treatment of diabetic vasculopathy analyzing multi-factor mediated disease-causing modules

Atherosclerosis-predominant vasculopathy is a common complication of diabetes with high morbidity and high mortality, which is ruining the patient's daily life. As is known to all, traditional Chinese medicine (TCM) SHENQI compound and western medicine rosiglitazone play an important role in th...

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Veröffentlicht in:	PloS one 2018-12, Vol.13 (12), p.e0207683-e0207683
Hauptverfasser:	Gao, Hong, Duan, Yuhong, Fu, Xiaoxu, Xie, Hongyan, Liu, Ya, Yuan, Haipo, Zhou, Mingyang, Xie, Chunguang
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Angiogenesis Animal models Animals Aorta, Abdominal - drug effects Aorta, Abdominal - pathology Arteriosclerosis Asian medicine Atherosclerosis Bioinformatics Biology Biology and Life Sciences Blood glucose Bumetanide Cardiovascular Agents - therapeutic use Chemical compounds Chinese medicine Clinical medicine Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Experimental - pathology Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - pathology Diabetes therapy Diabetic angiopathies Diabetic Angiopathies - drug therapy Diabetic Angiopathies - genetics Diabetic Angiopathies - pathology Disease Models, Animal Dosage and administration Drug therapy Drugs Drugs, Chinese Herbal - therapeutic use Endocrinology Gene expression Gene Expression - drug effects Genes Genetic aspects Genetic research Glucose Glyburide Herbal medicine House mouse Humans Hyperglycemia Hypoglycemic agents Hypoglycemic Agents - therapeutic use Insulin resistance Interferon regulatory factor 7 Lesions Male Medical treatment Medicine and Health Sciences Medicine, Chinese Traditional Metabolism Mice Mice, Inbred C57BL Mice, Mutant Strains Modules Morbidity Mortality Pathogenesis Pharmacology Physical characteristics Physiology Phytotherapy Rosiglitazone Rosiglitazone - therapeutic use Rosiglitazone maleate Signal transduction Signal Transduction - genetics Substance abuse treatment Traditional Chinese medicine Type 2 diabetes Vascular diseases
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