Association of pre-eclampsia risk with maternal levels of folate, homocysteine and vitamin B12 in Colombia: A case-control study
Maternal serum concentrations of folate, homocysteine, and vitamin B12 have been associated with pre-eclampsia. Nevertheless, reported studies involve limited number of cases to reliably assess the nature of these associations. Our aim was to examine the relation of these three biomarkers with pre-e...
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| Veröffentlicht in: | PloS one 2018-12, Vol.13 (12), p.e0208137-e0208137 |
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| creator | Serrano, Norma C Quintero-Lesmes, Doris Cristina Becerra-Bayona, Silvia Guio, Elizabeth Beltran, Mónica Paez, María C Ortiz, Ricardo Saldarriaga, Wilmar Diaz, Luis A Monterrosa, Álvaro Miranda, Jezid Mesa, Clara M Sanin, José E Monsalve, German Dudbridge, Frank Hingorani, Aroon D Casas, Juan P |
| description | Maternal serum concentrations of folate, homocysteine, and vitamin B12 have been associated with pre-eclampsia. Nevertheless, reported studies involve limited number of cases to reliably assess the nature of these associations. Our aim was to examine the relation of these three biomarkers with pre-eclampsia risk in a large Colombian population.
Design: A case-control study. Setting: Cases of pre-eclampsia and healthy pregnant controls were recruited at the time of delivery from eight different Colombian cities between 2000 and 2012. Population or Sample: 2978 cases and 4096 controls were studied. Maternal serum concentrations of folate, homocysteine, and vitamin B12 were determined in 1148 (43.6%) cases and 1300 (31.7%) controls. Also, self-reported folic acid supplementation was recorded for 2563 (84%) cases and 3155 (84%) controls. Analysis: Adjusted odds ratios (OR) for pre-eclampsia were estimated for one standard deviation (1SD) increase in log-transformed biomarkers. Furthermore, we conducted analyses to compare women that reported taking folic acid supplementation for different periods during pregnancy. Main Outcomes Measures: Odds ratio for pre-eclampsia.
After adjusting for potential confounders in logistic regression models, the OR for pre-eclampsia was 0.80 (95% CI: 0.72, 0.90) for 1SD increase in log-folate, 1.16 (95%CI: 1.05, 1.27) for 1SD increase in log-homocysteine, and 1.10 (95%CI: 0.99, 1.22) for 1SD increase in log-vitamin B12. No interactions among the biomarkers were identified. Women who self-reported consumption of folic acid (1 mg/day) throughout their pregnancy had an adjusted OR for pre-eclampsia of 0.86 (95%CI: 0.67, 1.09) compared to women that reported no consumption of folic acid at any point during pregnancy.
Maternal serum concentrations of folate were associated as a protective factor for pre-eclampsia while concentrations of homocysteine were associated as a risk factor. No association between maternal vitamin B12 concentrations and preeclampsia was found. |
| doi_str_mv | 10.1371/journal.pone.0208137 |
| format | Article |
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Design: A case-control study. Setting: Cases of pre-eclampsia and healthy pregnant controls were recruited at the time of delivery from eight different Colombian cities between 2000 and 2012. Population or Sample: 2978 cases and 4096 controls were studied. Maternal serum concentrations of folate, homocysteine, and vitamin B12 were determined in 1148 (43.6%) cases and 1300 (31.7%) controls. Also, self-reported folic acid supplementation was recorded for 2563 (84%) cases and 3155 (84%) controls. Analysis: Adjusted odds ratios (OR) for pre-eclampsia were estimated for one standard deviation (1SD) increase in log-transformed biomarkers. Furthermore, we conducted analyses to compare women that reported taking folic acid supplementation for different periods during pregnancy. Main Outcomes Measures: Odds ratio for pre-eclampsia.
After adjusting for potential confounders in logistic regression models, the OR for pre-eclampsia was 0.80 (95% CI: 0.72, 0.90) for 1SD increase in log-folate, 1.16 (95%CI: 1.05, 1.27) for 1SD increase in log-homocysteine, and 1.10 (95%CI: 0.99, 1.22) for 1SD increase in log-vitamin B12. No interactions among the biomarkers were identified. Women who self-reported consumption of folic acid (1 mg/day) throughout their pregnancy had an adjusted OR for pre-eclampsia of 0.86 (95%CI: 0.67, 1.09) compared to women that reported no consumption of folic acid at any point during pregnancy.
Maternal serum concentrations of folate were associated as a protective factor for pre-eclampsia while concentrations of homocysteine were associated as a risk factor. No association between maternal vitamin B12 concentrations and preeclampsia was found.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0208137</identifier><identifier>PMID: 30521542</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acids ; Adolescent ; Adult ; Amino acids ; Analysis ; Bioindicators ; Biological markers ; Biology and Life Sciences ; Biomarkers ; Biomarkers - blood ; Blood serum ; Cardiovascular disease ; Case studies ; Case-Control Studies ; Cities and towns ; Colombia - epidemiology ; Control methods ; Cyanocobalamin ; Eclampsia ; Female ; Folic acid ; Folic Acid - blood ; Health aspects ; Health care ; Health informatics ; Health risk assessment ; Homocysteine ; Homocysteine - blood ; Humans ; Hypertension ; Medicine and Health Sciences ; People and Places ; Physical Sciences ; Pre-eclampsia ; Pre-Eclampsia - blood ; Pre-Eclampsia - epidemiology ; Preeclampsia ; Pregnancy ; Pregnant women ; Regression analysis ; Regression models ; Research and Analysis Methods ; Risk analysis ; Risk factors ; Studies ; Supplements ; Vitamin B ; Vitamin B 12 - blood ; Vitamin B12 ; Vitamins ; Womens health ; Young Adult</subject><ispartof>PloS one, 2018-12, Vol.13 (12), p.e0208137-e0208137</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Serrano et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 Serrano et al 2018 Serrano et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-fff4ab2bc2d8051d760e2c51095e6cd88e72596c5d8c06d1e88aac3aea6cb12c3</citedby><cites>FETCH-LOGICAL-c692t-fff4ab2bc2d8051d760e2c51095e6cd88e72596c5d8c06d1e88aac3aea6cb12c3</cites><orcidid>0000-0003-3532-2002</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283543/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283543/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30521542$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Rosenfeld, Cheryl S.</contributor><creatorcontrib>Serrano, Norma C</creatorcontrib><creatorcontrib>Quintero-Lesmes, Doris Cristina</creatorcontrib><creatorcontrib>Becerra-Bayona, Silvia</creatorcontrib><creatorcontrib>Guio, Elizabeth</creatorcontrib><creatorcontrib>Beltran, Mónica</creatorcontrib><creatorcontrib>Paez, María C</creatorcontrib><creatorcontrib>Ortiz, Ricardo</creatorcontrib><creatorcontrib>Saldarriaga, Wilmar</creatorcontrib><creatorcontrib>Diaz, Luis A</creatorcontrib><creatorcontrib>Monterrosa, Álvaro</creatorcontrib><creatorcontrib>Miranda, Jezid</creatorcontrib><creatorcontrib>Mesa, Clara M</creatorcontrib><creatorcontrib>Sanin, José E</creatorcontrib><creatorcontrib>Monsalve, German</creatorcontrib><creatorcontrib>Dudbridge, Frank</creatorcontrib><creatorcontrib>Hingorani, Aroon D</creatorcontrib><creatorcontrib>Casas, Juan P</creatorcontrib><title>Association of pre-eclampsia risk with maternal levels of folate, homocysteine and vitamin B12 in Colombia: A case-control study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Maternal serum concentrations of folate, homocysteine, and vitamin B12 have been associated with pre-eclampsia. Nevertheless, reported studies involve limited number of cases to reliably assess the nature of these associations. Our aim was to examine the relation of these three biomarkers with pre-eclampsia risk in a large Colombian population.
Design: A case-control study. Setting: Cases of pre-eclampsia and healthy pregnant controls were recruited at the time of delivery from eight different Colombian cities between 2000 and 2012. Population or Sample: 2978 cases and 4096 controls were studied. Maternal serum concentrations of folate, homocysteine, and vitamin B12 were determined in 1148 (43.6%) cases and 1300 (31.7%) controls. Also, self-reported folic acid supplementation was recorded for 2563 (84%) cases and 3155 (84%) controls. Analysis: Adjusted odds ratios (OR) for pre-eclampsia were estimated for one standard deviation (1SD) increase in log-transformed biomarkers. Furthermore, we conducted analyses to compare women that reported taking folic acid supplementation for different periods during pregnancy. Main Outcomes Measures: Odds ratio for pre-eclampsia.
After adjusting for potential confounders in logistic regression models, the OR for pre-eclampsia was 0.80 (95% CI: 0.72, 0.90) for 1SD increase in log-folate, 1.16 (95%CI: 1.05, 1.27) for 1SD increase in log-homocysteine, and 1.10 (95%CI: 0.99, 1.22) for 1SD increase in log-vitamin B12. No interactions among the biomarkers were identified. Women who self-reported consumption of folic acid (1 mg/day) throughout their pregnancy had an adjusted OR for pre-eclampsia of 0.86 (95%CI: 0.67, 1.09) compared to women that reported no consumption of folic acid at any point during pregnancy.
Maternal serum concentrations of folate were associated as a protective factor for pre-eclampsia while concentrations of homocysteine were associated as a risk factor. No association between maternal vitamin B12 concentrations and preeclampsia was found.</description><subject>Acids</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Amino acids</subject><subject>Analysis</subject><subject>Bioindicators</subject><subject>Biological markers</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Blood serum</subject><subject>Cardiovascular disease</subject><subject>Case studies</subject><subject>Case-Control Studies</subject><subject>Cities and towns</subject><subject>Colombia - epidemiology</subject><subject>Control methods</subject><subject>Cyanocobalamin</subject><subject>Eclampsia</subject><subject>Female</subject><subject>Folic acid</subject><subject>Folic Acid - blood</subject><subject>Health aspects</subject><subject>Health care</subject><subject>Health informatics</subject><subject>Health risk assessment</subject><subject>Homocysteine</subject><subject>Homocysteine - blood</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Medicine and Health Sciences</subject><subject>People and Places</subject><subject>Physical Sciences</subject><subject>Pre-eclampsia</subject><subject>Pre-Eclampsia - blood</subject><subject>Pre-Eclampsia - epidemiology</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>Pregnant women</subject><subject>Regression analysis</subject><subject>Regression models</subject><subject>Research and Analysis Methods</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Studies</subject><subject>Supplements</subject><subject>Vitamin B</subject><subject>Vitamin B 12 - blood</subject><subject>Vitamin B12</subject><subject>Vitamins</subject><subject>Womens health</subject><subject>Young 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Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Serrano, Norma C</au><au>Quintero-Lesmes, Doris Cristina</au><au>Becerra-Bayona, Silvia</au><au>Guio, Elizabeth</au><au>Beltran, Mónica</au><au>Paez, María C</au><au>Ortiz, Ricardo</au><au>Saldarriaga, Wilmar</au><au>Diaz, Luis A</au><au>Monterrosa, Álvaro</au><au>Miranda, Jezid</au><au>Mesa, Clara M</au><au>Sanin, José E</au><au>Monsalve, German</au><au>Dudbridge, Frank</au><au>Hingorani, Aroon D</au><au>Casas, Juan P</au><au>Rosenfeld, Cheryl S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of pre-eclampsia risk with maternal levels of folate, homocysteine and vitamin B12 in Colombia: A case-control study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2018-12-06</date><risdate>2018</risdate><volume>13</volume><issue>12</issue><spage>e0208137</spage><epage>e0208137</epage><pages>e0208137-e0208137</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Maternal serum concentrations of folate, homocysteine, and vitamin B12 have been associated with pre-eclampsia. Nevertheless, reported studies involve limited number of cases to reliably assess the nature of these associations. Our aim was to examine the relation of these three biomarkers with pre-eclampsia risk in a large Colombian population.
Design: A case-control study. Setting: Cases of pre-eclampsia and healthy pregnant controls were recruited at the time of delivery from eight different Colombian cities between 2000 and 2012. Population or Sample: 2978 cases and 4096 controls were studied. Maternal serum concentrations of folate, homocysteine, and vitamin B12 were determined in 1148 (43.6%) cases and 1300 (31.7%) controls. Also, self-reported folic acid supplementation was recorded for 2563 (84%) cases and 3155 (84%) controls. Analysis: Adjusted odds ratios (OR) for pre-eclampsia were estimated for one standard deviation (1SD) increase in log-transformed biomarkers. Furthermore, we conducted analyses to compare women that reported taking folic acid supplementation for different periods during pregnancy. Main Outcomes Measures: Odds ratio for pre-eclampsia.
After adjusting for potential confounders in logistic regression models, the OR for pre-eclampsia was 0.80 (95% CI: 0.72, 0.90) for 1SD increase in log-folate, 1.16 (95%CI: 1.05, 1.27) for 1SD increase in log-homocysteine, and 1.10 (95%CI: 0.99, 1.22) for 1SD increase in log-vitamin B12. No interactions among the biomarkers were identified. Women who self-reported consumption of folic acid (1 mg/day) throughout their pregnancy had an adjusted OR for pre-eclampsia of 0.86 (95%CI: 0.67, 1.09) compared to women that reported no consumption of folic acid at any point during pregnancy.
Maternal serum concentrations of folate were associated as a protective factor for pre-eclampsia while concentrations of homocysteine were associated as a risk factor. No association between maternal vitamin B12 concentrations and preeclampsia was found.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>30521542</pmid><doi>10.1371/journal.pone.0208137</doi><tpages>e0208137</tpages><orcidid>https://orcid.org/0000-0003-3532-2002</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2018-12, Vol.13 (12), p.e0208137-e0208137 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2151204017 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Acids Adolescent Adult Amino acids Analysis Bioindicators Biological markers Biology and Life Sciences Biomarkers Biomarkers - blood Blood serum Cardiovascular disease Case studies Case-Control Studies Cities and towns Colombia - epidemiology Control methods Cyanocobalamin Eclampsia Female Folic acid Folic Acid - blood Health aspects Health care Health informatics Health risk assessment Homocysteine Homocysteine - blood Humans Hypertension Medicine and Health Sciences People and Places Physical Sciences Pre-eclampsia Pre-Eclampsia - blood Pre-Eclampsia - epidemiology Preeclampsia Pregnancy Pregnant women Regression analysis Regression models Research and Analysis Methods Risk analysis Risk factors Studies Supplements Vitamin B Vitamin B 12 - blood Vitamin B12 Vitamins Womens health Young Adult |
| title | Association of pre-eclampsia risk with maternal levels of folate, homocysteine and vitamin B12 in Colombia: A case-control study |
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