Antioxidant, photoprotective and inhibitory activity of tyrosinase in extracts of Dalbergia ecastaphyllum
Dalbergia ecastaphyllum is a native Brazil plant with importance for beekeeping, and widely used in folk medicine. For the first time, the extracts of this plant were assessed for the presence of hydrophilic and lipophilic antioxidants, as well as inhibition of tyrosinase, free radicals scavenging a...
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| creator | Morais, Daniel Vieira de Costa, Maria Angélica Pereira de Carvalho Santa Bárbara, Marivalda Figueredo Silva, Fabiane de Lima Moreira, Manuela M Delerue-Mato, Cristina Guimarães Dias, Luís Avelino Estevinho, Maria Leticia Miranda Carvalho, Carlos Alfredo Lopes de |
| description | Dalbergia ecastaphyllum is a native Brazil plant with importance for beekeeping, and widely used in folk medicine. For the first time, the extracts of this plant were assessed for the presence of hydrophilic and lipophilic antioxidants, as well as inhibition of tyrosinase, free radicals scavenging and sunscreen protection. The antioxidant activity was evaluated by free radical scavenging (DPPH) and β-carotene bleaching assay. The tyrosinase inhibitory activity was evaluated and calculated the EC50. The photoprotective activity was measured using different concentrations of D. ecastaphyllum extracts. The Sun Protection Factor (SPF) of the samples was higher than 6, and the sample from Ilhéus showed the most pronounced photoprotective effect. Sample from Canavieiras presented the highest antioxidant activity by free radical scavenging DPPH and β-carotene bleaching method, with 92.41% and 48.34%, respectively. All samples inhibited the tyrosinase, especially the sample from Prado that was most effective (124.62 μg.mL-1). Significant negative correlation was found between flavonoid contents and inhibition of tyrosinase. The overall results provide relevant information about the Dalbergia ecastaphyllum species, indicating as potential material to cosmetic and pharmaceutical industry. |
| doi_str_mv | 10.1371/journal.pone.0207510 |
| format | Article |
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For the first time, the extracts of this plant were assessed for the presence of hydrophilic and lipophilic antioxidants, as well as inhibition of tyrosinase, free radicals scavenging and sunscreen protection. The antioxidant activity was evaluated by free radical scavenging (DPPH) and β-carotene bleaching assay. The tyrosinase inhibitory activity was evaluated and calculated the EC50. The photoprotective activity was measured using different concentrations of D. ecastaphyllum extracts. The Sun Protection Factor (SPF) of the samples was higher than 6, and the sample from Ilhéus showed the most pronounced photoprotective effect. Sample from Canavieiras presented the highest antioxidant activity by free radical scavenging DPPH and β-carotene bleaching method, with 92.41% and 48.34%, respectively. All samples inhibited the tyrosinase, especially the sample from Prado that was most effective (124.62 μg.mL-1). Significant negative correlation was found between flavonoid contents and inhibition of tyrosinase. The overall results provide relevant information about the Dalbergia ecastaphyllum species, indicating as potential material to cosmetic and pharmaceutical industry.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0207510</identifier><identifier>PMID: 30500832</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Antioxidants ; Antioxidants (Nutrients) ; Antioxidants - chemistry ; Antioxidants - pharmacology ; Apiculture ; Beekeeping ; Beta carotene ; Biology and Life Sciences ; Bleaching ; Carotene ; Carotenoids ; College campuses ; Dalbergia - chemistry ; Dalbergia ecastaphyllum ; Dopamine ; Enzyme Inhibitors - chemistry ; Enzyme Inhibitors - pharmacology ; Enzymes ; Flavonoids ; Free radicals ; Health aspects ; Humans ; Inhibition ; Legumes ; Lipophilic ; Medicinal plants ; Monophenol Monooxygenase - antagonists & inhibitors ; Pharmaceutical industry ; Physical Sciences ; Plant extracts ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Plant Leaves - chemistry ; Properties ; Research and Analysis Methods ; Scavenging ; Sun screens ; Sunscreening Agents - chemistry ; Sunscreening Agents - pharmacology ; Tyrosinase ; β-Carotene</subject><ispartof>PloS one, 2018-11, Vol.13 (11), p.e0207510</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Morais et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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Significant negative correlation was found between flavonoid contents and inhibition of tyrosinase. The overall results provide relevant information about the Dalbergia ecastaphyllum species, indicating as potential material to cosmetic and pharmaceutical industry.</description><subject>Antioxidants</subject><subject>Antioxidants (Nutrients)</subject><subject>Antioxidants - chemistry</subject><subject>Antioxidants - pharmacology</subject><subject>Apiculture</subject><subject>Beekeeping</subject><subject>Beta carotene</subject><subject>Biology and Life Sciences</subject><subject>Bleaching</subject><subject>Carotene</subject><subject>Carotenoids</subject><subject>College campuses</subject><subject>Dalbergia - chemistry</subject><subject>Dalbergia ecastaphyllum</subject><subject>Dopamine</subject><subject>Enzyme Inhibitors - chemistry</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Enzymes</subject><subject>Flavonoids</subject><subject>Free radicals</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Inhibition</subject><subject>Legumes</subject><subject>Lipophilic</subject><subject>Medicinal plants</subject><subject>Monophenol Monooxygenase - 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For the first time, the extracts of this plant were assessed for the presence of hydrophilic and lipophilic antioxidants, as well as inhibition of tyrosinase, free radicals scavenging and sunscreen protection. The antioxidant activity was evaluated by free radical scavenging (DPPH) and β-carotene bleaching assay. The tyrosinase inhibitory activity was evaluated and calculated the EC50. The photoprotective activity was measured using different concentrations of D. ecastaphyllum extracts. The Sun Protection Factor (SPF) of the samples was higher than 6, and the sample from Ilhéus showed the most pronounced photoprotective effect. Sample from Canavieiras presented the highest antioxidant activity by free radical scavenging DPPH and β-carotene bleaching method, with 92.41% and 48.34%, respectively. All samples inhibited the tyrosinase, especially the sample from Prado that was most effective (124.62 μg.mL-1). Significant negative correlation was found between flavonoid contents and inhibition of tyrosinase. The overall results provide relevant information about the Dalbergia ecastaphyllum species, indicating as potential material to cosmetic and pharmaceutical industry.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>30500832</pmid><doi>10.1371/journal.pone.0207510</doi><tpages>e0207510</tpages><orcidid>https://orcid.org/0000-0002-2737-7428</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2018-11, Vol.13 (11), p.e0207510 |
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| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Antioxidants Antioxidants (Nutrients) Antioxidants - chemistry Antioxidants - pharmacology Apiculture Beekeeping Beta carotene Biology and Life Sciences Bleaching Carotene Carotenoids College campuses Dalbergia - chemistry Dalbergia ecastaphyllum Dopamine Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Enzymes Flavonoids Free radicals Health aspects Humans Inhibition Legumes Lipophilic Medicinal plants Monophenol Monooxygenase - antagonists & inhibitors Pharmaceutical industry Physical Sciences Plant extracts Plant Extracts - chemistry Plant Extracts - pharmacology Plant Leaves - chemistry Properties Research and Analysis Methods Scavenging Sun screens Sunscreening Agents - chemistry Sunscreening Agents - pharmacology Tyrosinase β-Carotene |
| title | Antioxidant, photoprotective and inhibitory activity of tyrosinase in extracts of Dalbergia ecastaphyllum |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T05%3A52%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Antioxidant,%20photoprotective%20and%20inhibitory%20activity%20of%20tyrosinase%20in%20extracts%20of%20Dalbergia%20ecastaphyllum&rft.jtitle=PloS%20one&rft.au=Morais,%20Daniel%20Vieira%20de&rft.date=2018-11-30&rft.volume=13&rft.issue=11&rft.spage=e0207510&rft.pages=e0207510-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0207510&rft_dat=%3Cgale_plos_%3EA563926403%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2140078880&rft_id=info:pmid/30500832&rft_galeid=A563926403&rft_doaj_id=oai_doaj_org_article_e6d0a148c6d547b599c1f622ded65b49&rfr_iscdi=true |