Expansion of the multidrug-resistant clonal complex 320 among invasive Streptococcus pneumoniae serotype 19A after the introduction of a ten-valent pneumococcal conjugate vaccine in Brazil
In 2010, a ten-valent pneumococcal conjugate vaccine (PCV10) was introduced in the routine infant national immunization program in Brazil. Invasive pneumococcal disease (IPD) caused by serotype 19A (Spn19A) increased after the introduction of PCVs in several countries. We compared the frequency, ant...
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| creator | Cassiolato, Ana Paula Almeida, Samanta Cristine Grassi Andrade, Ana Lúcia Minamisava, Ruth Brandileone, Maria Cristina de Cunto |
| description | In 2010, a ten-valent pneumococcal conjugate vaccine (PCV10) was introduced in the routine infant national immunization program in Brazil. Invasive pneumococcal disease (IPD) caused by serotype 19A (Spn19A) increased after the introduction of PCVs in several countries. We compared the frequency, antimicrobial resistance and molecular patterns of invasive Spn19A strains before and after PCV10 introduction in Brazil using data from the national laboratory-based surveillance.
We analyzed invasive Spn19A strains isolated from 2005-2009 (pre-PCV10 period), 2011-2015 and 2016-2017 (post-PCV10 periods). Antimicrobial susceptibility was performed for all Spn19A strains, and multilocus sequence typing (MLST) was performed for strains isolated in the age groups |
| doi_str_mv | 10.1371/journal.pone.0208211 |
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We analyzed invasive Spn19A strains isolated from 2005-2009 (pre-PCV10 period), 2011-2015 and 2016-2017 (post-PCV10 periods). Antimicrobial susceptibility was performed for all Spn19A strains, and multilocus sequence typing (MLST) was performed for strains isolated in the age groups <5 years and ≥50 years.
Among the study period, a total of 9,852 invasive Spn strains were analyzed, and 673 (6.8%) belonged to serotype 19A. Overall, the proportion of Spn19A among the total number of IPD strains increased from 2.8% in 2005-2009 to 7.0% and 16.4% in 2011-2015 and 2016-2017, respectively. The relative increase in Spn19A was observed especially in children <5 years old (2005-2009: 3.2%; 2011-2015: 15.5%; 2016-2017: 31.2%). The percentage of penicillin resistance (MIC 2.0-4.0 μg/mL), erythromycin resistance and multidrug resistance (MDR) increased after PCV10 introduction due to the expansion of the MDR clonal complex CC320 (2005-2009: 8.6%; 2011-2015: 56.1%; 2016-2017: 66.5%).
We observed an expansion of MDR-CC320 among invasive Spn19A strains after PCV10 introduction in Brazil, probably related to a combination of factors, such as vaccination and antimicrobial pressure. Continued surveillance of Spn19A strains is necessary to monitor the sustainability of this clonal complex in the Brazilian population.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0208211</identifier><identifier>PMID: 30496296</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Anti-Bacterial Agents - pharmacology ; Antibacterial agents ; Antibiotics ; Antiinfectives and antibacterials ; Antimicrobial agents ; Antimicrobial resistance ; Bacterial Typing Techniques ; Biology and Life Sciences ; Brazil - epidemiology ; Child ; Child, Preschool ; Children ; Conjugates ; Drug resistance ; Drug Resistance, Bacterial ; Drug Resistance, Multiple ; Elderly ; Erythromycin ; Expansion ; Health aspects ; Humans ; Immunization ; Laboratories ; Medicine and Health Sciences ; Microbial drug resistance ; Middle Aged ; Multidrug resistance ; Multidrug resistant organisms ; Multilocus Sequence Typing ; Penicillin ; Penicillins ; People and Places ; Pneumococcal infections ; Pneumococcal Infections - drug therapy ; Pneumococcal Infections - epidemiology ; Pneumococcal Infections - prevention & control ; Pneumococcal Vaccines - therapeutic use ; Pneumonia ; Risk factors ; Serogroup ; Streptococcus infections ; Streptococcus pneumoniae ; Streptococcus pneumoniae - drug effects ; Streptococcus pneumoniae - genetics ; Streptococcus pneumoniae - isolation & purification ; Surveillance ; Sustainability ; Sustainable development ; Vaccination ; Vaccines ; Young Adult</subject><ispartof>PloS one, 2018-11, Vol.13 (11), p.e0208211-e0208211</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Cassiolato et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 Cassiolato et al 2018 Cassiolato et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6731-a8f7a5d98698d53956095735bb4a1ecda6b26517d6d599a8362569b7a80c34543</citedby><cites>FETCH-LOGICAL-c6731-a8f7a5d98698d53956095735bb4a1ecda6b26517d6d599a8362569b7a80c34543</cites><orcidid>0000-0002-7254-9102 ; 0000-0001-5007-5383</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264150/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264150/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2929,23871,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30496296$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Hiller, N.Luisa</contributor><creatorcontrib>Cassiolato, Ana Paula</creatorcontrib><creatorcontrib>Almeida, Samanta Cristine Grassi</creatorcontrib><creatorcontrib>Andrade, Ana Lúcia</creatorcontrib><creatorcontrib>Minamisava, Ruth</creatorcontrib><creatorcontrib>Brandileone, Maria Cristina de Cunto</creatorcontrib><title>Expansion of the multidrug-resistant clonal complex 320 among invasive Streptococcus pneumoniae serotype 19A after the introduction of a ten-valent pneumococcal conjugate vaccine in Brazil</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>In 2010, a ten-valent pneumococcal conjugate vaccine (PCV10) was introduced in the routine infant national immunization program in Brazil. Invasive pneumococcal disease (IPD) caused by serotype 19A (Spn19A) increased after the introduction of PCVs in several countries. We compared the frequency, antimicrobial resistance and molecular patterns of invasive Spn19A strains before and after PCV10 introduction in Brazil using data from the national laboratory-based surveillance.
We analyzed invasive Spn19A strains isolated from 2005-2009 (pre-PCV10 period), 2011-2015 and 2016-2017 (post-PCV10 periods). Antimicrobial susceptibility was performed for all Spn19A strains, and multilocus sequence typing (MLST) was performed for strains isolated in the age groups <5 years and ≥50 years.
Among the study period, a total of 9,852 invasive Spn strains were analyzed, and 673 (6.8%) belonged to serotype 19A. Overall, the proportion of Spn19A among the total number of IPD strains increased from 2.8% in 2005-2009 to 7.0% and 16.4% in 2011-2015 and 2016-2017, respectively. The relative increase in Spn19A was observed especially in children <5 years old (2005-2009: 3.2%; 2011-2015: 15.5%; 2016-2017: 31.2%). The percentage of penicillin resistance (MIC 2.0-4.0 μg/mL), erythromycin resistance and multidrug resistance (MDR) increased after PCV10 introduction due to the expansion of the MDR clonal complex CC320 (2005-2009: 8.6%; 2011-2015: 56.1%; 2016-2017: 66.5%).
We observed an expansion of MDR-CC320 among invasive Spn19A strains after PCV10 introduction in Brazil, probably related to a combination of factors, such as vaccination and antimicrobial pressure. 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drug therapy</subject><subject>Pneumococcal Infections - epidemiology</subject><subject>Pneumococcal Infections - prevention & control</subject><subject>Pneumococcal Vaccines - therapeutic use</subject><subject>Pneumonia</subject><subject>Risk factors</subject><subject>Serogroup</subject><subject>Streptococcus infections</subject><subject>Streptococcus pneumoniae</subject><subject>Streptococcus pneumoniae - drug effects</subject><subject>Streptococcus pneumoniae - genetics</subject><subject>Streptococcus pneumoniae - isolation & purification</subject><subject>Surveillance</subject><subject>Sustainability</subject><subject>Sustainable development</subject><subject>Vaccination</subject><subject>Vaccines</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk1Fr1TAYhosobk7_gWhAEL04x6Rp0-ZGmGPqYDBw6m34Tpr25JAmNUkPm7_NH2e6040d2YX0oiV53vdNvq9flr0keEloRT5s3OgtmOXgrFriHNc5IY-yQ8JpvmA5po_vfR9kz0LYYFzSmrGn2QHFBWc5Z4fZn9OrAWzQziLXorhWqB9N1I0fu4VXQYcINiJpXIpC0vWDUVeI5hhB72yHtN1C0FuFLqNXQ3TSSTkGNFg1pn0NCgXlXbweFCL8GEEblb9J0TZ614wyzsmAorKLLRiV4nbyyesm1G7GDqJCW5BS20mLPnn4rc3z7EkLJqgX8_so-_H59PvJ18X5xZezk-PzhWQVJQuo2wrKhteM101JeckwLytarlYFECUbYKuclaRqWFNyDjVlecn4qoIaS1qUBT3KXu98B-OCmAsfRE6SFyd1KutRdrYjGgcbMXjdg78WDrS4WXC-E-CjlkaJnGIMvCLQroqiqlquailTR1ve1KmLkLw-zmnjqleNTBXxYPZM93esXovObQXLWUFKnAzezQbe_RpViKLXQSpjwCo3TucuCC4YLuqEvvkHffh2M9Wl_ghtW5dy5WQqjktGK57TkiZq-QCVnkb1OnVRtTqt7wne7wkSE9VV7GAMQZxdfvt_9uLnPvv2HrtWYOI6ODNO_1rYB4sdKL0Lwav2rsgEi2nIbqshpiET85Al2av7DboT3U4V_QvLeyR5</recordid><startdate>20181129</startdate><enddate>20181129</enddate><creator>Cassiolato, Ana Paula</creator><creator>Almeida, Samanta Cristine Grassi</creator><creator>Andrade, Ana Lúcia</creator><creator>Minamisava, Ruth</creator><creator>Brandileone, Maria Cristina de Cunto</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-7254-9102</orcidid><orcidid>https://orcid.org/0000-0001-5007-5383</orcidid></search><sort><creationdate>20181129</creationdate><title>Expansion of the multidrug-resistant clonal complex 320 among invasive Streptococcus pneumoniae serotype 19A after the introduction of a ten-valent pneumococcal conjugate vaccine in Brazil</title><author>Cassiolato, Ana Paula ; Almeida, Samanta Cristine Grassi ; Andrade, Ana Lúcia ; Minamisava, Ruth ; Brandileone, Maria Cristina de Cunto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6731-a8f7a5d98698d53956095735bb4a1ecda6b26517d6d599a8362569b7a80c34543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Anti-Bacterial Agents - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cassiolato, Ana Paula</au><au>Almeida, Samanta Cristine Grassi</au><au>Andrade, Ana Lúcia</au><au>Minamisava, Ruth</au><au>Brandileone, Maria Cristina de Cunto</au><au>Hiller, N.Luisa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expansion of the multidrug-resistant clonal complex 320 among invasive Streptococcus pneumoniae serotype 19A after the introduction of a ten-valent pneumococcal conjugate vaccine in Brazil</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2018-11-29</date><risdate>2018</risdate><volume>13</volume><issue>11</issue><spage>e0208211</spage><epage>e0208211</epage><pages>e0208211-e0208211</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>In 2010, a ten-valent pneumococcal conjugate vaccine (PCV10) was introduced in the routine infant national immunization program in Brazil. Invasive pneumococcal disease (IPD) caused by serotype 19A (Spn19A) increased after the introduction of PCVs in several countries. We compared the frequency, antimicrobial resistance and molecular patterns of invasive Spn19A strains before and after PCV10 introduction in Brazil using data from the national laboratory-based surveillance.
We analyzed invasive Spn19A strains isolated from 2005-2009 (pre-PCV10 period), 2011-2015 and 2016-2017 (post-PCV10 periods). Antimicrobial susceptibility was performed for all Spn19A strains, and multilocus sequence typing (MLST) was performed for strains isolated in the age groups <5 years and ≥50 years.
Among the study period, a total of 9,852 invasive Spn strains were analyzed, and 673 (6.8%) belonged to serotype 19A. Overall, the proportion of Spn19A among the total number of IPD strains increased from 2.8% in 2005-2009 to 7.0% and 16.4% in 2011-2015 and 2016-2017, respectively. The relative increase in Spn19A was observed especially in children <5 years old (2005-2009: 3.2%; 2011-2015: 15.5%; 2016-2017: 31.2%). The percentage of penicillin resistance (MIC 2.0-4.0 μg/mL), erythromycin resistance and multidrug resistance (MDR) increased after PCV10 introduction due to the expansion of the MDR clonal complex CC320 (2005-2009: 8.6%; 2011-2015: 56.1%; 2016-2017: 66.5%).
We observed an expansion of MDR-CC320 among invasive Spn19A strains after PCV10 introduction in Brazil, probably related to a combination of factors, such as vaccination and antimicrobial pressure. Continued surveillance of Spn19A strains is necessary to monitor the sustainability of this clonal complex in the Brazilian population.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>30496296</pmid><doi>10.1371/journal.pone.0208211</doi><tpages>e0208211</tpages><orcidid>https://orcid.org/0000-0002-7254-9102</orcidid><orcidid>https://orcid.org/0000-0001-5007-5383</orcidid><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_2139591805 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adolescent Adult Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics Antiinfectives and antibacterials Antimicrobial agents Antimicrobial resistance Bacterial Typing Techniques Biology and Life Sciences Brazil - epidemiology Child Child, Preschool Children Conjugates Drug resistance Drug Resistance, Bacterial Drug Resistance, Multiple Elderly Erythromycin Expansion Health aspects Humans Immunization Laboratories Medicine and Health Sciences Microbial drug resistance Middle Aged Multidrug resistance Multidrug resistant organisms Multilocus Sequence Typing Penicillin Penicillins People and Places Pneumococcal infections Pneumococcal Infections - drug therapy Pneumococcal Infections - epidemiology Pneumococcal Infections - prevention & control Pneumococcal Vaccines - therapeutic use Pneumonia Risk factors Serogroup Streptococcus infections Streptococcus pneumoniae Streptococcus pneumoniae - drug effects Streptococcus pneumoniae - genetics Streptococcus pneumoniae - isolation & purification Surveillance Sustainability Sustainable development Vaccination Vaccines Young Adult |
| title | Expansion of the multidrug-resistant clonal complex 320 among invasive Streptococcus pneumoniae serotype 19A after the introduction of a ten-valent pneumococcal conjugate vaccine in Brazil |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-16T07%3A02%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Expansion%20of%20the%20multidrug-resistant%20clonal%20complex%20320%20among%20invasive%20Streptococcus%20pneumoniae%20serotype%2019A%20after%20the%20introduction%20of%20a%20ten-valent%20pneumococcal%20conjugate%20vaccine%20in%20Brazil&rft.jtitle=PloS%20one&rft.au=Cassiolato,%20Ana%20Paula&rft.date=2018-11-29&rft.volume=13&rft.issue=11&rft.spage=e0208211&rft.epage=e0208211&rft.pages=e0208211-e0208211&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0208211&rft_dat=%3Cgale_plos_%3EA563792353%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2139591805&rft_id=info:pmid/30496296&rft_galeid=A563792353&rft_doaj_id=oai_doaj_org_article_2300a971afb4477f9e8cc137f9d8208a&rfr_iscdi=true |