Network assessment of demethylation treatment in melanoma: Differential transcriptome-methylome and antigen profile signatures

In melanoma, like in other cancers, both genetic alterations and epigenetic underlie the metastatic process. These effects are usually measured by changes in both methylome and transcriptome profiles, whose cross-correlation remains uncertain. We aimed to assess at systems scale the significance of...

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Veröffentlicht in:	PloS one 2018-11, Vol.13 (11), p.e0206686-e0206686
Hauptverfasser:	Jiang, Zhijie, Cinti, Caterina, Taranta, Monia, Mattioli, Elisabetta, Schena, Elisa, Singh, Sakshi, Khurana, Rimpi, Lattanzi, Giovanna, Tsinoremas, Nicholas F, Capobianco, Enrico
Format:	Artikel
Sprache:	eng
Schlagworte:	Annotations Antigen (tumor-associated) Antigens Antigens - metabolism Antimetabolites, Antineoplastic - pharmacology Apoptosis Bioindicators Bioinformatics Biological activity Biological markers Biology and life sciences Biomarkers Biotechnology Cancer Cancer metastasis Cancer therapies Cancer treatment Care and treatment Cell adhesion Cell adhesion & migration Cell cycle Cell Line, Tumor Correlation analysis Data integration Decitabine - pharmacology Demethylation Deoxyribonucleic acid Disease Progression DNA DNA methylation DNA Methylation - drug effects DNA repair Epigenesis, Genetic - drug effects Epigenetic inheritance Epigenetics Gene expression Gene Expression Regulation, Neoplastic - drug effects Gene mapping Genes Genetic aspects Genetic research Genetics Genomes Genomics Humans Integrins Lymphatic Metastasis - physiopathology Medicine and Health Sciences Melanoma Melanoma - drug therapy Melanoma - genetics Melanoma - metabolism Metastases Metastasis Methylation Non-coding RNA Physiology Protein Interaction Maps - drug effects Proteins Ribonucleic acid RNA RNA sequencing RNA, Long Noncoding - metabolism Signatures Skin Neoplasms - drug therapy Skin Neoplasms - genetics Skin Neoplasms - metabolism Target recognition Transcription Transcriptome - drug effects Tumor antigens Tumors
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