Anxiety and depression in Klinefelter syndrome: The impact of personality and social engagement
Klinefelter syndrome (KS) (47, XXY) is the most common sex chromosome disorder, with a prevalence of 1 in every 660 newborn males. Despite the profound adverse effects of anxiety and depression, and their greater prevalence in KS populations, no research has been conducted to date to identify the de...
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| Veröffentlicht in: | PloS one 2018-11, Vol.13 (11), p.e0206932-e0206932 |
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| creator | Skakkebæk, Anne Moore, Philip J Pedersen, Anders Degn Bojesen, Anders Kristensen, Maria Krarup Fedder, Jens Hertz, Jens Michael Østergaard, John R Wallentin, Mikkel Gravholt, Claus Højbjerg |
| description | Klinefelter syndrome (KS) (47, XXY) is the most common sex chromosome disorder, with a prevalence of 1 in every 660 newborn males. Despite the profound adverse effects of anxiety and depression, and their greater prevalence in KS populations, no research has been conducted to date to identify the determinants of anxiety and depression among patients with KS. We examined the relationships between personality traits, social engagement, and anxiety and depression symptoms among KS patients (n = 69) and a group of male controls (n = 69) matched for age and years of education. KS patients experienced more anxiety and depression symptoms than control participants. Neuroticism was the strongest and most consistent mediator between KS and both anxiety and depression symptoms. This research suggests that neuroticism may play a central role in attention switching, anxiety and depression among patients with Klinefelter syndrome. The central role of neuroticism suggests that it may be used to help identify and treat KS patients at particularly high-risk for attention-switching deficits, anxiety and depression. |
| doi_str_mv | 10.1371/journal.pone.0206932 |
| format | Article |
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Despite the profound adverse effects of anxiety and depression, and their greater prevalence in KS populations, no research has been conducted to date to identify the determinants of anxiety and depression among patients with KS. We examined the relationships between personality traits, social engagement, and anxiety and depression symptoms among KS patients (n = 69) and a group of male controls (n = 69) matched for age and years of education. KS patients experienced more anxiety and depression symptoms than control participants. Neuroticism was the strongest and most consistent mediator between KS and both anxiety and depression symptoms. This research suggests that neuroticism may play a central role in attention switching, anxiety and depression among patients with Klinefelter syndrome. The central role of neuroticism suggests that it may be used to help identify and treat KS patients at particularly high-risk for attention-switching deficits, anxiety and depression.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0206932</identifier><identifier>PMID: 30412595</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age ; Anxiety ; Biology and Life Sciences ; Education ; Endocrinology ; Experimental psychology ; Hospitals ; Internal medicine ; Klinefelter's syndrome ; Males ; Medicine ; Medicine and Health Sciences ; Mental depression ; Mental disorders ; Mental health care ; Neurosis ; Patients ; Personality ; Personality traits ; Psychiatry ; Psychopathology ; Quality of life ; Social Sciences ; Social skills ; Socioeconomic factors ; Switching ; Systematic review ; Testosterone</subject><ispartof>PloS one, 2018-11, Vol.13 (11), p.e0206932-e0206932</ispartof><rights>2018 Skakkebæk et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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Despite the profound adverse effects of anxiety and depression, and their greater prevalence in KS populations, no research has been conducted to date to identify the determinants of anxiety and depression among patients with KS. We examined the relationships between personality traits, social engagement, and anxiety and depression symptoms among KS patients (n = 69) and a group of male controls (n = 69) matched for age and years of education. KS patients experienced more anxiety and depression symptoms than control participants. Neuroticism was the strongest and most consistent mediator between KS and both anxiety and depression symptoms. This research suggests that neuroticism may play a central role in attention switching, anxiety and depression among patients with Klinefelter syndrome. The central role of neuroticism suggests that it may be used to help identify and treat KS patients at particularly high-risk for attention-switching deficits, anxiety and depression.</description><subject>Age</subject><subject>Anxiety</subject><subject>Biology and Life Sciences</subject><subject>Education</subject><subject>Endocrinology</subject><subject>Experimental psychology</subject><subject>Hospitals</subject><subject>Internal medicine</subject><subject>Klinefelter's syndrome</subject><subject>Males</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Mental depression</subject><subject>Mental disorders</subject><subject>Mental health care</subject><subject>Neurosis</subject><subject>Patients</subject><subject>Personality</subject><subject>Personality traits</subject><subject>Psychiatry</subject><subject>Psychopathology</subject><subject>Quality of life</subject><subject>Social Sciences</subject><subject>Social 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engagement</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2018-11-09</date><risdate>2018</risdate><volume>13</volume><issue>11</issue><spage>e0206932</spage><epage>e0206932</epage><pages>e0206932-e0206932</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Klinefelter syndrome (KS) (47, XXY) is the most common sex chromosome disorder, with a prevalence of 1 in every 660 newborn males. Despite the profound adverse effects of anxiety and depression, and their greater prevalence in KS populations, no research has been conducted to date to identify the determinants of anxiety and depression among patients with KS. We examined the relationships between personality traits, social engagement, and anxiety and depression symptoms among KS patients (n = 69) and a group of male controls (n = 69) matched for age and years of education. KS patients experienced more anxiety and depression symptoms than control participants. Neuroticism was the strongest and most consistent mediator between KS and both anxiety and depression symptoms. This research suggests that neuroticism may play a central role in attention switching, anxiety and depression among patients with Klinefelter syndrome. The central role of neuroticism suggests that it may be used to help identify and treat KS patients at particularly high-risk for attention-switching deficits, anxiety and depression.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>30412595</pmid><doi>10.1371/journal.pone.0206932</doi><orcidid>https://orcid.org/0000-0001-9178-4901</orcidid><orcidid>https://orcid.org/0000-0001-5383-5501</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Age Anxiety Biology and Life Sciences Education Endocrinology Experimental psychology Hospitals Internal medicine Klinefelter's syndrome Males Medicine Medicine and Health Sciences Mental depression Mental disorders Mental health care Neurosis Patients Personality Personality traits Psychiatry Psychopathology Quality of life Social Sciences Social skills Socioeconomic factors Switching Systematic review Testosterone |
| title | Anxiety and depression in Klinefelter syndrome: The impact of personality and social engagement |
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