Substrate-independent immunomodulatory characteristics of mesenchymal stem cells in three-dimensional culture

Mesenchymal stem cells (MSCs) play important roles in tissue regeneration, and multi-lineage differentiation and immunomodulation are two major characteristics of MSCs that are utilized in stem cell therapy. MSCs in vivo have a markedly different three-dimensional (3D) niche compared to the traditio...

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Veröffentlicht in:	PloS one 2018-11, Vol.13 (11), p.e0206811-e0206811
Hauptverfasser:	Li, Jing, Chen, Tong, Huang, Xiahe, Zhao, Yunshan, Wang, Bin, Yin, Yanyun, Cui, Yi, Zhao, Yannan, Zhang, Ruiping, Wang, Xiujie, Wang, Yingchun, Dai, Jianwu
Format:	Artikel
Sprache:	eng
Schlagworte:	Arthritis Biology and Life Sciences Biomedical materials Bone marrow Cell adhesion & migration Cell culture Cell Culture Techniques - methods Cell Differentiation - immunology Cell Proliferation Developmental biology Differentiation Gene expression Genomics Growth factors Guided Tissue Regeneration Hospitals Humans Immunomodulation Immunoregulation Immunosuppression Immunosuppressive agents Laboratories Medicine and Health Sciences Mesenchymal stem cells Mesenchymal Stem Cells - immunology Mesenchyme Morphology Pattern analysis Phenotypes Proteins Proteomics Regeneration Research and Analysis Methods Scanning electron microscopy Stem cells Substrates Tissue engineering Tissue Scaffolds Topography Umbilical cord
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