Comparison of clinical symptoms, gastric motility and fat intake in the early chronic pancreatitis patients with anti-acid therapy-resistant functional dyspepsia patients
There was no available data concerning the clinical differentiation between the updated definition of early chronic pancreatitis (ECP) and anti-acid therapy-resistant functional dyspepsia (RFD). We aimed to determine whether clinical symptoms, gastric motility, psychogenic factors and fat intake can...
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| Veröffentlicht in: | PloS one 2018-11, Vol.13 (11), p.e0205165-e0205165 |
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| creator | Wakabayashi, Mako Futagami, Seiji Yamawaki, Hiroshi Tatsuguchi, Atsushi Kaneko, Keiko Agawa, Shuhei Higuchi, Kazutoshi Sakasegawa, Noriko Murakami, Makoto Akimoto, Teppei Kodaka, Yasuhiro Ueki, Nobue Gudis, Kaya Kawamoto, Chiaki Akamizu, Takashi Sakamoto, Choitsu Iwakiri, Katsuhiko |
| description | There was no available data concerning the clinical differentiation between the updated definition of early chronic pancreatitis (ECP) and anti-acid therapy-resistant functional dyspepsia (RFD).
We aimed to determine whether clinical symptoms, gastric motility, psychogenic factors and fat intake can help distinguish early chronic pancreatitis (ECP) from anti-acid therapy-resistant functional dyspepsia patients with pancreatic enzyme abnormalities (RFD-P) and anti-acid therapy-resistant functional dyspepsia (RFD) patients using endosonography.
We enrolled 102 consecutive patients presenting with typical symptoms of RFD patients (n = 52), ECP patients (n = 25) and RFD-P patients (n = 25). ECP patients were diagnosed based on the criteria recommended by the Japan Pancreatic Association. Gastric motility was evaluated by 13C-acetate breath tests. Severity of duodenal inflammation was examined.
24.5% of RFD patients were determined as ECP using endosonography. Abdominal pain score in Gastrointestinal Symptom Rating Scale (GSRS) in the patients with ECP was significantly lower compared to that in the patients with RFD-P. There were no significant differences in State-Trait Inventory (STAI)-state/-trait scores, Self-Rating Questionnaire for Depression (SRQ-D) scores and clinical symptoms for fat intake among three groups. The early phase of gastric emptying (AUC5; AUC15) in ECP and RFD-P patients were significantly disturbed compared to those in RFD patients.
Evaluation of severity of abdominal pain and measurement of the early phase of gastric emptying will be useful tools to distinguish ECP patients from RFD patients. Accurate diagnosis of ECP patients may contribute to the prevention from advancing of chronic pancreatitis. |
| doi_str_mv | 10.1371/journal.pone.0205165 |
| format | Article |
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We aimed to determine whether clinical symptoms, gastric motility, psychogenic factors and fat intake can help distinguish early chronic pancreatitis (ECP) from anti-acid therapy-resistant functional dyspepsia patients with pancreatic enzyme abnormalities (RFD-P) and anti-acid therapy-resistant functional dyspepsia (RFD) patients using endosonography.
We enrolled 102 consecutive patients presenting with typical symptoms of RFD patients (n = 52), ECP patients (n = 25) and RFD-P patients (n = 25). ECP patients were diagnosed based on the criteria recommended by the Japan Pancreatic Association. Gastric motility was evaluated by 13C-acetate breath tests. Severity of duodenal inflammation was examined.
24.5% of RFD patients were determined as ECP using endosonography. Abdominal pain score in Gastrointestinal Symptom Rating Scale (GSRS) in the patients with ECP was significantly lower compared to that in the patients with RFD-P. There were no significant differences in State-Trait Inventory (STAI)-state/-trait scores, Self-Rating Questionnaire for Depression (SRQ-D) scores and clinical symptoms for fat intake among three groups. The early phase of gastric emptying (AUC5; AUC15) in ECP and RFD-P patients were significantly disturbed compared to those in RFD patients.
Evaluation of severity of abdominal pain and measurement of the early phase of gastric emptying will be useful tools to distinguish ECP patients from RFD patients. Accurate diagnosis of ECP patients may contribute to the prevention from advancing of chronic pancreatitis.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0205165</identifier><identifier>PMID: 30403664</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Abdomen ; Abnormalities ; Acetic acid ; Acid resistance ; Acids ; Adult ; Anti-Ulcer Agents - therapeutic use ; Anxiety ; Biology and Life Sciences ; Diabetes ; Dietary Fats - administration & dosage ; Disease Management ; Drug Resistance ; Dyspepsia ; Dyspepsia - diagnosis ; Dyspepsia - drug therapy ; Dyspepsia - physiopathology ; Emptying ; Endoscopy ; Endosonography ; Enzymes ; Female ; Gastric Emptying ; Gastric motility ; Gastroenterology ; Gastrointestinal Motility ; Humans ; Internal medicine ; Male ; Meals ; Medical diagnosis ; Medical schools ; Medicine ; Medicine and Health Sciences ; Mental depression ; Middle Aged ; Motility ; Pain ; Pancreas ; Pancreatic Function Tests ; Pancreatitis ; Pancreatitis, Chronic - diagnosis ; Pancreatitis, Chronic - physiopathology ; Patients ; Research and Analysis Methods ; Risk Factors ; Social Sciences ; Symptom Assessment ; Therapy ; Ultrasonic imaging ; Workflow</subject><ispartof>PloS one, 2018-11, Vol.13 (11), p.e0205165-e0205165</ispartof><rights>2018 Wakabayashi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 Wakabayashi et al 2018 Wakabayashi et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-c125ceeffa07f653103259da79b7f993f18ca32fc33dba686f164dcf85cf0aba3</citedby><cites>FETCH-LOGICAL-c456t-c125ceeffa07f653103259da79b7f993f18ca32fc33dba686f164dcf85cf0aba3</cites><orcidid>0000-0003-0502-8646</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221270/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221270/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30403664$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wakabayashi, Mako</creatorcontrib><creatorcontrib>Futagami, Seiji</creatorcontrib><creatorcontrib>Yamawaki, Hiroshi</creatorcontrib><creatorcontrib>Tatsuguchi, Atsushi</creatorcontrib><creatorcontrib>Kaneko, Keiko</creatorcontrib><creatorcontrib>Agawa, Shuhei</creatorcontrib><creatorcontrib>Higuchi, Kazutoshi</creatorcontrib><creatorcontrib>Sakasegawa, Noriko</creatorcontrib><creatorcontrib>Murakami, Makoto</creatorcontrib><creatorcontrib>Akimoto, Teppei</creatorcontrib><creatorcontrib>Kodaka, Yasuhiro</creatorcontrib><creatorcontrib>Ueki, Nobue</creatorcontrib><creatorcontrib>Gudis, Kaya</creatorcontrib><creatorcontrib>Kawamoto, Chiaki</creatorcontrib><creatorcontrib>Akamizu, Takashi</creatorcontrib><creatorcontrib>Sakamoto, Choitsu</creatorcontrib><creatorcontrib>Iwakiri, Katsuhiko</creatorcontrib><title>Comparison of clinical symptoms, gastric motility and fat intake in the early chronic pancreatitis patients with anti-acid therapy-resistant functional dyspepsia patients</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>There was no available data concerning the clinical differentiation between the updated definition of early chronic pancreatitis (ECP) and anti-acid therapy-resistant functional dyspepsia (RFD).
We aimed to determine whether clinical symptoms, gastric motility, psychogenic factors and fat intake can help distinguish early chronic pancreatitis (ECP) from anti-acid therapy-resistant functional dyspepsia patients with pancreatic enzyme abnormalities (RFD-P) and anti-acid therapy-resistant functional dyspepsia (RFD) patients using endosonography.
We enrolled 102 consecutive patients presenting with typical symptoms of RFD patients (n = 52), ECP patients (n = 25) and RFD-P patients (n = 25). ECP patients were diagnosed based on the criteria recommended by the Japan Pancreatic Association. Gastric motility was evaluated by 13C-acetate breath tests. Severity of duodenal inflammation was examined.
24.5% of RFD patients were determined as ECP using endosonography. Abdominal pain score in Gastrointestinal Symptom Rating Scale (GSRS) in the patients with ECP was significantly lower compared to that in the patients with RFD-P. There were no significant differences in State-Trait Inventory (STAI)-state/-trait scores, Self-Rating Questionnaire for Depression (SRQ-D) scores and clinical symptoms for fat intake among three groups. The early phase of gastric emptying (AUC5; AUC15) in ECP and RFD-P patients were significantly disturbed compared to those in RFD patients.
Evaluation of severity of abdominal pain and measurement of the early phase of gastric emptying will be useful tools to distinguish ECP patients from RFD patients. Accurate diagnosis of ECP patients may contribute to the prevention from advancing of chronic pancreatitis.</description><subject>Abdomen</subject><subject>Abnormalities</subject><subject>Acetic acid</subject><subject>Acid resistance</subject><subject>Acids</subject><subject>Adult</subject><subject>Anti-Ulcer Agents - therapeutic use</subject><subject>Anxiety</subject><subject>Biology and Life Sciences</subject><subject>Diabetes</subject><subject>Dietary Fats - administration & dosage</subject><subject>Disease Management</subject><subject>Drug Resistance</subject><subject>Dyspepsia</subject><subject>Dyspepsia - diagnosis</subject><subject>Dyspepsia - drug therapy</subject><subject>Dyspepsia - physiopathology</subject><subject>Emptying</subject><subject>Endoscopy</subject><subject>Endosonography</subject><subject>Enzymes</subject><subject>Female</subject><subject>Gastric Emptying</subject><subject>Gastric motility</subject><subject>Gastroenterology</subject><subject>Gastrointestinal Motility</subject><subject>Humans</subject><subject>Internal medicine</subject><subject>Male</subject><subject>Meals</subject><subject>Medical diagnosis</subject><subject>Medical schools</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Mental depression</subject><subject>Middle Aged</subject><subject>Motility</subject><subject>Pain</subject><subject>Pancreas</subject><subject>Pancreatic Function Tests</subject><subject>Pancreatitis</subject><subject>Pancreatitis, Chronic - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wakabayashi, Mako</au><au>Futagami, Seiji</au><au>Yamawaki, Hiroshi</au><au>Tatsuguchi, Atsushi</au><au>Kaneko, Keiko</au><au>Agawa, Shuhei</au><au>Higuchi, Kazutoshi</au><au>Sakasegawa, Noriko</au><au>Murakami, Makoto</au><au>Akimoto, Teppei</au><au>Kodaka, Yasuhiro</au><au>Ueki, Nobue</au><au>Gudis, Kaya</au><au>Kawamoto, Chiaki</au><au>Akamizu, Takashi</au><au>Sakamoto, Choitsu</au><au>Iwakiri, Katsuhiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of clinical symptoms, gastric motility and fat intake in the early chronic pancreatitis patients with anti-acid therapy-resistant functional dyspepsia patients</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2018-11-07</date><risdate>2018</risdate><volume>13</volume><issue>11</issue><spage>e0205165</spage><epage>e0205165</epage><pages>e0205165-e0205165</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>There was no available data concerning the clinical differentiation between the updated definition of early chronic pancreatitis (ECP) and anti-acid therapy-resistant functional dyspepsia (RFD).
We aimed to determine whether clinical symptoms, gastric motility, psychogenic factors and fat intake can help distinguish early chronic pancreatitis (ECP) from anti-acid therapy-resistant functional dyspepsia patients with pancreatic enzyme abnormalities (RFD-P) and anti-acid therapy-resistant functional dyspepsia (RFD) patients using endosonography.
We enrolled 102 consecutive patients presenting with typical symptoms of RFD patients (n = 52), ECP patients (n = 25) and RFD-P patients (n = 25). ECP patients were diagnosed based on the criteria recommended by the Japan Pancreatic Association. Gastric motility was evaluated by 13C-acetate breath tests. Severity of duodenal inflammation was examined.
24.5% of RFD patients were determined as ECP using endosonography. Abdominal pain score in Gastrointestinal Symptom Rating Scale (GSRS) in the patients with ECP was significantly lower compared to that in the patients with RFD-P. There were no significant differences in State-Trait Inventory (STAI)-state/-trait scores, Self-Rating Questionnaire for Depression (SRQ-D) scores and clinical symptoms for fat intake among three groups. The early phase of gastric emptying (AUC5; AUC15) in ECP and RFD-P patients were significantly disturbed compared to those in RFD patients.
Evaluation of severity of abdominal pain and measurement of the early phase of gastric emptying will be useful tools to distinguish ECP patients from RFD patients. Accurate diagnosis of ECP patients may contribute to the prevention from advancing of chronic pancreatitis.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>30403664</pmid><doi>10.1371/journal.pone.0205165</doi><orcidid>https://orcid.org/0000-0003-0502-8646</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2018-11, Vol.13 (11), p.e0205165-e0205165 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2130793927 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Abdomen Abnormalities Acetic acid Acid resistance Acids Adult Anti-Ulcer Agents - therapeutic use Anxiety Biology and Life Sciences Diabetes Dietary Fats - administration & dosage Disease Management Drug Resistance Dyspepsia Dyspepsia - diagnosis Dyspepsia - drug therapy Dyspepsia - physiopathology Emptying Endoscopy Endosonography Enzymes Female Gastric Emptying Gastric motility Gastroenterology Gastrointestinal Motility Humans Internal medicine Male Meals Medical diagnosis Medical schools Medicine Medicine and Health Sciences Mental depression Middle Aged Motility Pain Pancreas Pancreatic Function Tests Pancreatitis Pancreatitis, Chronic - diagnosis Pancreatitis, Chronic - physiopathology Patients Research and Analysis Methods Risk Factors Social Sciences Symptom Assessment Therapy Ultrasonic imaging Workflow |
| title | Comparison of clinical symptoms, gastric motility and fat intake in the early chronic pancreatitis patients with anti-acid therapy-resistant functional dyspepsia patients |
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