Evaluation of gastroprotective and ulcer healing activities of yellow mombin juice from Spondias mombin L
Spondias mombin L. (yellow mombin) is a tree with a nutritional fruit that is commonly consumed in the North and Northeast of Brazil, as the juice of its pulp is rich in antioxidant compounds. This study aimed to investigate the gastroprotective and ulcer healing activities of yellow mombin juice (Y...
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| Veröffentlicht in: | PloS one 2018-11, Vol.13 (11), p.e0201561-e0201561 |
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| creator | Brito, Samara A Barbosa, Isabela S de Almeida, Cynthia L F de Medeiros, Jonathan W Silva Neto, Jacinto C Rolim, Larissa A da Silva, Teresinha G Ximenes, Rafael M de Menezes, Irwin R A \ Caldas, Germana F R Wanderley, Almir G |
| description | Spondias mombin L. (yellow mombin) is a tree with a nutritional fruit that is commonly consumed in the North and Northeast of Brazil, as the juice of its pulp is rich in antioxidant compounds. This study aimed to investigate the gastroprotective and ulcer healing activities of yellow mombin juice (YMJ) in Wistar rats, and to elucidate the possible involved mechanisms. Phytochemical characterization of the lyophilized fruit juice was performed by high-performance liquid chromatography (HPLC). The gastroprotective activity of YMJ was investigated in ethanol (25, 50, and 100% YMJ) and indomethacin (100% YMJ) models of acute gastric ulcer in rats. Then, the effect of YMJ on mucus production and gastric secretions, and the involvement of non-protein sulfhydryl groups and prostaglandins in the gastroprotective process were examined. Moreover, the ulcer healing effect of YMJ was investigated in a model of acetic acid-induced chronic ulcer through histological and immunohistochemical analyses. HPLC results identified the presence of epicatechin (7.1 ± 1.6 μg/mL) and quercetin (17.3 ± 2.5 μg/mL) in YMJ. Ethanol-induced gastric lesions were inhibited by YMJ (25, 50, and 100%) by 42.42, 45.09, and 98.21% respectively, and indomethacin-induced lesions were inhibited by YMJ (100%) by 58.96%, compared to control group. Moreover, YMJ reduced gastric content and total acidy by 57.35 and 71.97%, respectively, compared to the control group. Treatment with YMJ also promoted healing of chronic ulcer, regeneration of the gastric mucosa, and restoration of mucus levels in glandular cells, as confirmed by histological analysis. It also increased cellular proliferation, as demonstrated by high reactivity to Ki-67 and bromodeoxyuridine. In conclusion, YMJ was found to possess gastroprotective and ulcer healing activities that are correlated to its antisecretory action. These results support the commercial exploration of YMJ as a functional food. |
| doi_str_mv | 10.1371/journal.pone.0201561 |
| format | Article |
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(yellow mombin) is a tree with a nutritional fruit that is commonly consumed in the North and Northeast of Brazil, as the juice of its pulp is rich in antioxidant compounds. This study aimed to investigate the gastroprotective and ulcer healing activities of yellow mombin juice (YMJ) in Wistar rats, and to elucidate the possible involved mechanisms. Phytochemical characterization of the lyophilized fruit juice was performed by high-performance liquid chromatography (HPLC). The gastroprotective activity of YMJ was investigated in ethanol (25, 50, and 100% YMJ) and indomethacin (100% YMJ) models of acute gastric ulcer in rats. Then, the effect of YMJ on mucus production and gastric secretions, and the involvement of non-protein sulfhydryl groups and prostaglandins in the gastroprotective process were examined. Moreover, the ulcer healing effect of YMJ was investigated in a model of acetic acid-induced chronic ulcer through histological and immunohistochemical analyses. HPLC results identified the presence of epicatechin (7.1 ± 1.6 μg/mL) and quercetin (17.3 ± 2.5 μg/mL) in YMJ. Ethanol-induced gastric lesions were inhibited by YMJ (25, 50, and 100%) by 42.42, 45.09, and 98.21% respectively, and indomethacin-induced lesions were inhibited by YMJ (100%) by 58.96%, compared to control group. Moreover, YMJ reduced gastric content and total acidy by 57.35 and 71.97%, respectively, compared to the control group. Treatment with YMJ also promoted healing of chronic ulcer, regeneration of the gastric mucosa, and restoration of mucus levels in glandular cells, as confirmed by histological analysis. It also increased cellular proliferation, as demonstrated by high reactivity to Ki-67 and bromodeoxyuridine. In conclusion, YMJ was found to possess gastroprotective and ulcer healing activities that are correlated to its antisecretory action. These results support the commercial exploration of YMJ as a functional food.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0201561</identifier><identifier>PMID: 30395566</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acetic acid ; Acids ; Anacardiaceae ; Animals ; Antibiotics ; Antioxidants ; Biology and Life Sciences ; Bromodeoxyuridine ; Cell proliferation ; Chromatography ; Drug Evaluation, Preclinical ; Epicatechin ; Ethanol ; Ethanol - adverse effects ; Ethanol - pharmacology ; Female ; Fruit and Vegetable Juices ; Fruit juices ; Fruits ; Functional foods ; Functional foods & nutraceuticals ; Gastric mucosa ; Gastric Mucosa - metabolism ; Gastric Mucosa - pathology ; Healing ; High performance liquid chromatography ; Indomethacin ; Inhibition ; Juices ; Lesions ; Liquid chromatography ; Male ; Medicine and Health Sciences ; Mucosa ; Mucus ; Pharmaceutical sciences ; Physical Sciences ; Physiology ; Phytochemicals ; Prostaglandins ; Proteins ; Pulp ; Quercetin ; Rats ; Rats, Wistar ; Regeneration ; Restoration ; Secretions ; Spondias mombin ; Stomach Ulcer - chemically induced ; Stomach Ulcer - drug therapy ; Stomach Ulcer - metabolism ; Stomach Ulcer - pathology ; Studies ; Sulfhydryl groups ; Ulcers</subject><ispartof>PloS one, 2018-11, Vol.13 (11), p.e0201561-e0201561</ispartof><rights>2018 Brito et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 Brito et al 2018 Brito et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-ef9096588cea65c1dc563c057fd8a0855a1d68ca3826ceeecb60f6dbe4975a8e3</citedby><cites>FETCH-LOGICAL-c526t-ef9096588cea65c1dc563c057fd8a0855a1d68ca3826ceeecb60f6dbe4975a8e3</cites><orcidid>0000-0001-5193-1153 ; 0000-0002-2011-2865 ; 0000-0003-4418-801X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218193/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218193/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2929,23871,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30395566$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Magierowski, Marcin</contributor><creatorcontrib>Brito, Samara A</creatorcontrib><creatorcontrib>Barbosa, Isabela S</creatorcontrib><creatorcontrib>de Almeida, Cynthia L F</creatorcontrib><creatorcontrib>de Medeiros, Jonathan W</creatorcontrib><creatorcontrib>Silva Neto, Jacinto C</creatorcontrib><creatorcontrib>Rolim, Larissa A</creatorcontrib><creatorcontrib>da Silva, Teresinha G</creatorcontrib><creatorcontrib>Ximenes, Rafael M</creatorcontrib><creatorcontrib>de Menezes, Irwin R A \</creatorcontrib><creatorcontrib>Caldas, Germana F R</creatorcontrib><creatorcontrib>Wanderley, Almir G</creatorcontrib><title>Evaluation of gastroprotective and ulcer healing activities of yellow mombin juice from Spondias mombin L</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Spondias mombin L. (yellow mombin) is a tree with a nutritional fruit that is commonly consumed in the North and Northeast of Brazil, as the juice of its pulp is rich in antioxidant compounds. This study aimed to investigate the gastroprotective and ulcer healing activities of yellow mombin juice (YMJ) in Wistar rats, and to elucidate the possible involved mechanisms. Phytochemical characterization of the lyophilized fruit juice was performed by high-performance liquid chromatography (HPLC). The gastroprotective activity of YMJ was investigated in ethanol (25, 50, and 100% YMJ) and indomethacin (100% YMJ) models of acute gastric ulcer in rats. Then, the effect of YMJ on mucus production and gastric secretions, and the involvement of non-protein sulfhydryl groups and prostaglandins in the gastroprotective process were examined. Moreover, the ulcer healing effect of YMJ was investigated in a model of acetic acid-induced chronic ulcer through histological and immunohistochemical analyses. HPLC results identified the presence of epicatechin (7.1 ± 1.6 μg/mL) and quercetin (17.3 ± 2.5 μg/mL) in YMJ. Ethanol-induced gastric lesions were inhibited by YMJ (25, 50, and 100%) by 42.42, 45.09, and 98.21% respectively, and indomethacin-induced lesions were inhibited by YMJ (100%) by 58.96%, compared to control group. Moreover, YMJ reduced gastric content and total acidy by 57.35 and 71.97%, respectively, compared to the control group. Treatment with YMJ also promoted healing of chronic ulcer, regeneration of the gastric mucosa, and restoration of mucus levels in glandular cells, as confirmed by histological analysis. It also increased cellular proliferation, as demonstrated by high reactivity to Ki-67 and bromodeoxyuridine. In conclusion, YMJ was found to possess gastroprotective and ulcer healing activities that are correlated to its antisecretory action. These results support the commercial exploration of YMJ as a functional food.</description><subject>Acetic acid</subject><subject>Acids</subject><subject>Anacardiaceae</subject><subject>Animals</subject><subject>Antibiotics</subject><subject>Antioxidants</subject><subject>Biology and Life Sciences</subject><subject>Bromodeoxyuridine</subject><subject>Cell proliferation</subject><subject>Chromatography</subject><subject>Drug Evaluation, Preclinical</subject><subject>Epicatechin</subject><subject>Ethanol</subject><subject>Ethanol - adverse effects</subject><subject>Ethanol - pharmacology</subject><subject>Female</subject><subject>Fruit and Vegetable Juices</subject><subject>Fruit juices</subject><subject>Fruits</subject><subject>Functional foods</subject><subject>Functional foods & nutraceuticals</subject><subject>Gastric mucosa</subject><subject>Gastric Mucosa - metabolism</subject><subject>Gastric Mucosa - pathology</subject><subject>Healing</subject><subject>High performance liquid chromatography</subject><subject>Indomethacin</subject><subject>Inhibition</subject><subject>Juices</subject><subject>Lesions</subject><subject>Liquid chromatography</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Mucosa</subject><subject>Mucus</subject><subject>Pharmaceutical sciences</subject><subject>Physical Sciences</subject><subject>Physiology</subject><subject>Phytochemicals</subject><subject>Prostaglandins</subject><subject>Proteins</subject><subject>Pulp</subject><subject>Quercetin</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Regeneration</subject><subject>Restoration</subject><subject>Secretions</subject><subject>Spondias mombin</subject><subject>Stomach Ulcer - chemically induced</subject><subject>Stomach Ulcer - drug therapy</subject><subject>Stomach Ulcer - metabolism</subject><subject>Stomach Ulcer - pathology</subject><subject>Studies</subject><subject>Sulfhydryl groups</subject><subject>Ulcers</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNptUk1v0zAYthCIjcE_QGCJC5cWO64d54KEpsEmVeIAnK039pvOlRMXOynav8el6bRNnGz5-Xg__BDylrMlFzX_tI1TGiAsd3HAJasYl4o_I-e8EdVCVUw8f3A_I69y3jImhVbqJTkTTDRSKnVO_NUewgSjjwONHd1AHlPcpTiiHf0eKQyOTsFiorcIwQ8bCgfAjx7zQXCHIcQ_tI996we6nbxF2qXY0x-lL-chn6D1a_Kig5DxzXxekF9fr35eXi_W37_dXH5ZL6ys1LjArmGNklpbBCUtd1YqYZmsO6eBaSmBO6UtCF0pi4i2VaxTrsVVU0vQKC7I-6PvLsRs5i1lU3FR5ue1rgvj5shwEbZml3wP6c5E8ObfQ0wbA2n0NqBpG641Q2gV1qsGG-DCuRUqzbnUqKF4fZ6rTW2PzuIwJgiPTB8jg781m7g3quK6_E8x-DgbpPh7wjya3mdbtgoDxunYt2BVVbNC_fCE-v_pVkeWTTHnhN19M5yZQ3JOKnNIjpmTU2TvHg5yLzpFRfwF6qvD4g</recordid><startdate>20181105</startdate><enddate>20181105</enddate><creator>Brito, Samara A</creator><creator>Barbosa, Isabela S</creator><creator>de Almeida, Cynthia L F</creator><creator>de Medeiros, Jonathan W</creator><creator>Silva Neto, Jacinto C</creator><creator>Rolim, Larissa A</creator><creator>da Silva, Teresinha G</creator><creator>Ximenes, Rafael M</creator><creator>de Menezes, Irwin R A \</creator><creator>Caldas, Germana F R</creator><creator>Wanderley, Almir G</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-5193-1153</orcidid><orcidid>https://orcid.org/0000-0002-2011-2865</orcidid><orcidid>https://orcid.org/0000-0003-4418-801X</orcidid></search><sort><creationdate>20181105</creationdate><title>Evaluation of gastroprotective and ulcer healing activities of yellow mombin juice from Spondias mombin L</title><author>Brito, Samara A ; Barbosa, Isabela S ; de Almeida, Cynthia L F ; de Medeiros, Jonathan W ; Silva Neto, Jacinto C ; Rolim, Larissa A ; da Silva, Teresinha G ; Ximenes, Rafael M ; de Menezes, Irwin R A \ ; Caldas, Germana F R ; Wanderley, Almir G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-ef9096588cea65c1dc563c057fd8a0855a1d68ca3826ceeecb60f6dbe4975a8e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Acetic acid</topic><topic>Acids</topic><topic>Anacardiaceae</topic><topic>Animals</topic><topic>Antibiotics</topic><topic>Antioxidants</topic><topic>Biology and Life Sciences</topic><topic>Bromodeoxyuridine</topic><topic>Cell proliferation</topic><topic>Chromatography</topic><topic>Drug Evaluation, Preclinical</topic><topic>Epicatechin</topic><topic>Ethanol</topic><topic>Ethanol - adverse effects</topic><topic>Ethanol - pharmacology</topic><topic>Female</topic><topic>Fruit and Vegetable Juices</topic><topic>Fruit juices</topic><topic>Fruits</topic><topic>Functional foods</topic><topic>Functional foods & nutraceuticals</topic><topic>Gastric mucosa</topic><topic>Gastric Mucosa - metabolism</topic><topic>Gastric Mucosa - pathology</topic><topic>Healing</topic><topic>High performance liquid chromatography</topic><topic>Indomethacin</topic><topic>Inhibition</topic><topic>Juices</topic><topic>Lesions</topic><topic>Liquid chromatography</topic><topic>Male</topic><topic>Medicine and Health Sciences</topic><topic>Mucosa</topic><topic>Mucus</topic><topic>Pharmaceutical sciences</topic><topic>Physical Sciences</topic><topic>Physiology</topic><topic>Phytochemicals</topic><topic>Prostaglandins</topic><topic>Proteins</topic><topic>Pulp</topic><topic>Quercetin</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Regeneration</topic><topic>Restoration</topic><topic>Secretions</topic><topic>Spondias mombin</topic><topic>Stomach Ulcer - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brito, Samara A</au><au>Barbosa, Isabela S</au><au>de Almeida, Cynthia L F</au><au>de Medeiros, Jonathan W</au><au>Silva Neto, Jacinto C</au><au>Rolim, Larissa A</au><au>da Silva, Teresinha G</au><au>Ximenes, Rafael M</au><au>de Menezes, Irwin R A \</au><au>Caldas, Germana F R</au><au>Wanderley, Almir G</au><au>Magierowski, Marcin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of gastroprotective and ulcer healing activities of yellow mombin juice from Spondias mombin L</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2018-11-05</date><risdate>2018</risdate><volume>13</volume><issue>11</issue><spage>e0201561</spage><epage>e0201561</epage><pages>e0201561-e0201561</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Spondias mombin L. (yellow mombin) is a tree with a nutritional fruit that is commonly consumed in the North and Northeast of Brazil, as the juice of its pulp is rich in antioxidant compounds. This study aimed to investigate the gastroprotective and ulcer healing activities of yellow mombin juice (YMJ) in Wistar rats, and to elucidate the possible involved mechanisms. Phytochemical characterization of the lyophilized fruit juice was performed by high-performance liquid chromatography (HPLC). The gastroprotective activity of YMJ was investigated in ethanol (25, 50, and 100% YMJ) and indomethacin (100% YMJ) models of acute gastric ulcer in rats. Then, the effect of YMJ on mucus production and gastric secretions, and the involvement of non-protein sulfhydryl groups and prostaglandins in the gastroprotective process were examined. Moreover, the ulcer healing effect of YMJ was investigated in a model of acetic acid-induced chronic ulcer through histological and immunohistochemical analyses. HPLC results identified the presence of epicatechin (7.1 ± 1.6 μg/mL) and quercetin (17.3 ± 2.5 μg/mL) in YMJ. Ethanol-induced gastric lesions were inhibited by YMJ (25, 50, and 100%) by 42.42, 45.09, and 98.21% respectively, and indomethacin-induced lesions were inhibited by YMJ (100%) by 58.96%, compared to control group. Moreover, YMJ reduced gastric content and total acidy by 57.35 and 71.97%, respectively, compared to the control group. Treatment with YMJ also promoted healing of chronic ulcer, regeneration of the gastric mucosa, and restoration of mucus levels in glandular cells, as confirmed by histological analysis. It also increased cellular proliferation, as demonstrated by high reactivity to Ki-67 and bromodeoxyuridine. In conclusion, YMJ was found to possess gastroprotective and ulcer healing activities that are correlated to its antisecretory action. These results support the commercial exploration of YMJ as a functional food.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>30395566</pmid><doi>10.1371/journal.pone.0201561</doi><orcidid>https://orcid.org/0000-0001-5193-1153</orcidid><orcidid>https://orcid.org/0000-0002-2011-2865</orcidid><orcidid>https://orcid.org/0000-0003-4418-801X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2018-11, Vol.13 (11), p.e0201561-e0201561 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2130051787 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Acetic acid Acids Anacardiaceae Animals Antibiotics Antioxidants Biology and Life Sciences Bromodeoxyuridine Cell proliferation Chromatography Drug Evaluation, Preclinical Epicatechin Ethanol Ethanol - adverse effects Ethanol - pharmacology Female Fruit and Vegetable Juices Fruit juices Fruits Functional foods Functional foods & nutraceuticals Gastric mucosa Gastric Mucosa - metabolism Gastric Mucosa - pathology Healing High performance liquid chromatography Indomethacin Inhibition Juices Lesions Liquid chromatography Male Medicine and Health Sciences Mucosa Mucus Pharmaceutical sciences Physical Sciences Physiology Phytochemicals Prostaglandins Proteins Pulp Quercetin Rats Rats, Wistar Regeneration Restoration Secretions Spondias mombin Stomach Ulcer - chemically induced Stomach Ulcer - drug therapy Stomach Ulcer - metabolism Stomach Ulcer - pathology Studies Sulfhydryl groups Ulcers |
| title | Evaluation of gastroprotective and ulcer healing activities of yellow mombin juice from Spondias mombin L |
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