Nanoparticulate matter exposure results in neuroinflammatory changes in the corpus callosum
Epidemiological studies have established an association between air pollution particulate matter exposure (PM2.5) and neurocognitive decline. Experimental data suggest that microglia play an essential role in air pollution PM-induced neuroinflammation and oxidative stress. This study examined the ef...
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| Veröffentlicht in: | PloS one 2018-11, Vol.13 (11), p.e0206934 |
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| creator | Babadjouni, Robin Patel, Arati Liu, Qinghai Shkirkova, Kristina Lamorie-Foote, Krista Connor, Michelle Hodis, Drew M Cheng, Hank Sioutas, Constantinos Morgan, Todd E Finch, Caleb E Mack, William J |
| description | Epidemiological studies have established an association between air pollution particulate matter exposure (PM2.5) and neurocognitive decline. Experimental data suggest that microglia play an essential role in air pollution PM-induced neuroinflammation and oxidative stress. This study examined the effect of nano-sized particulate matter (nPM) on complement C5 deposition and microglial activation in the corpus callosum of mice (C57BL/6J males). nPM was collected in an urban Los Angeles region impacted by traffic emissions. Mice were exposed to 10 weeks of re-aerosolized nPM or filtered air for a cumulative 150 hours. nPM-exposed mice exhibited reactive microglia and 2-fold increased local deposition of complement C5/ C5α proteins and complement component C5a receptor 1 (CD88) in the corpus callosum. However, serum C5 levels did not differ between nPM and filtered air cohorts. These findings demonstrate white matter C5 deposition and microglial activation secondary to nPM exposure. The C5 upregulation appears to be localized to the brain. |
| doi_str_mv | 10.1371/journal.pone.0206934 |
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Experimental data suggest that microglia play an essential role in air pollution PM-induced neuroinflammation and oxidative stress. This study examined the effect of nano-sized particulate matter (nPM) on complement C5 deposition and microglial activation in the corpus callosum of mice (C57BL/6J males). nPM was collected in an urban Los Angeles region impacted by traffic emissions. Mice were exposed to 10 weeks of re-aerosolized nPM or filtered air for a cumulative 150 hours. nPM-exposed mice exhibited reactive microglia and 2-fold increased local deposition of complement C5/ C5α proteins and complement component C5a receptor 1 (CD88) in the corpus callosum. However, serum C5 levels did not differ between nPM and filtered air cohorts. These findings demonstrate white matter C5 deposition and microglial activation secondary to nPM exposure. The C5 upregulation appears to be localized to the brain.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0206934</identifier><identifier>PMID: 30395590</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Activation ; Air pollution ; Air Pollution - adverse effects ; Animals ; Atmospheric pollution ; Biology and Life Sciences ; Brain ; Cognition ; Complement ; Complement activation ; Complement C5 - genetics ; Complement component C5 ; Complement component C5a ; Corpus callosum ; Corpus Callosum - drug effects ; Corpus Callosum - pathology ; Cytokines ; Deposition ; Ecology and Environmental Sciences ; Epidemiology ; Exposure ; Gerontology ; Humans ; Inflammation ; Inflammation - chemically induced ; Inflammation - genetics ; Inflammation - physiopathology ; Laboratory animals ; Males ; Medicine ; Medicine and Health Sciences ; Mice ; Microglia ; Microglia - drug effects ; Microglia - metabolism ; Multiple sclerosis ; Nanoparticles ; Nanoparticles - adverse effects ; Neurocognitive Disorders - chemically induced ; Neurocognitive Disorders - genetics ; Neurocognitive Disorders - physiopathology ; Neurosciences ; Outdoor air quality ; Oxidative stress ; Oxidative Stress - drug effects ; Particulate emissions ; Particulate matter ; Particulate Matter - adverse effects ; Particulates ; Pathogenesis ; Physical Sciences ; Pollution ; Pollution effects ; Proteins ; Research and analysis methods ; Rodents ; Stroke ; Substantia alba ; Vehicle emissions</subject><ispartof>PloS one, 2018-11, Vol.13 (11), p.e0206934</ispartof><rights>2018 Babadjouni et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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Experimental data suggest that microglia play an essential role in air pollution PM-induced neuroinflammation and oxidative stress. This study examined the effect of nano-sized particulate matter (nPM) on complement C5 deposition and microglial activation in the corpus callosum of mice (C57BL/6J males). nPM was collected in an urban Los Angeles region impacted by traffic emissions. Mice were exposed to 10 weeks of re-aerosolized nPM or filtered air for a cumulative 150 hours. nPM-exposed mice exhibited reactive microglia and 2-fold increased local deposition of complement C5/ C5α proteins and complement component C5a receptor 1 (CD88) in the corpus callosum. However, serum C5 levels did not differ between nPM and filtered air cohorts. These findings demonstrate white matter C5 deposition and microglial activation secondary to nPM exposure. The C5 upregulation appears to be localized to the brain.</description><subject>Activation</subject><subject>Air pollution</subject><subject>Air Pollution - adverse effects</subject><subject>Animals</subject><subject>Atmospheric pollution</subject><subject>Biology and Life Sciences</subject><subject>Brain</subject><subject>Cognition</subject><subject>Complement</subject><subject>Complement activation</subject><subject>Complement C5 - genetics</subject><subject>Complement component C5</subject><subject>Complement component C5a</subject><subject>Corpus callosum</subject><subject>Corpus Callosum - drug effects</subject><subject>Corpus Callosum - pathology</subject><subject>Cytokines</subject><subject>Deposition</subject><subject>Ecology and Environmental Sciences</subject><subject>Epidemiology</subject><subject>Exposure</subject><subject>Gerontology</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation - chemically induced</subject><subject>Inflammation - genetics</subject><subject>Inflammation - physiopathology</subject><subject>Laboratory animals</subject><subject>Males</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Mice</subject><subject>Microglia</subject><subject>Microglia - drug effects</subject><subject>Microglia - metabolism</subject><subject>Multiple sclerosis</subject><subject>Nanoparticles</subject><subject>Nanoparticles - adverse effects</subject><subject>Neurocognitive Disorders - chemically induced</subject><subject>Neurocognitive Disorders - genetics</subject><subject>Neurocognitive Disorders - physiopathology</subject><subject>Neurosciences</subject><subject>Outdoor air quality</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Particulate emissions</subject><subject>Particulate matter</subject><subject>Particulate Matter - adverse effects</subject><subject>Particulates</subject><subject>Pathogenesis</subject><subject>Physical Sciences</subject><subject>Pollution</subject><subject>Pollution effects</subject><subject>Proteins</subject><subject>Research and analysis methods</subject><subject>Rodents</subject><subject>Stroke</subject><subject>Substantia alba</subject><subject>Vehicle 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matter exposure results in neuroinflammatory changes in the corpus callosum</title><author>Babadjouni, Robin ; Patel, Arati ; Liu, Qinghai ; Shkirkova, Kristina ; Lamorie-Foote, Krista ; Connor, Michelle ; Hodis, Drew M ; Cheng, Hank ; Sioutas, Constantinos ; Morgan, Todd E ; Finch, Caleb E ; Mack, William J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-1f27819355183218107d4c680b9d4ffc42778a1e0beb05a0db3f11cf5f444a6f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Activation</topic><topic>Air pollution</topic><topic>Air Pollution - adverse effects</topic><topic>Animals</topic><topic>Atmospheric pollution</topic><topic>Biology and Life Sciences</topic><topic>Brain</topic><topic>Cognition</topic><topic>Complement</topic><topic>Complement activation</topic><topic>Complement C5 - genetics</topic><topic>Complement component C5</topic><topic>Complement component 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| subjects | Activation Air pollution Air Pollution - adverse effects Animals Atmospheric pollution Biology and Life Sciences Brain Cognition Complement Complement activation Complement C5 - genetics Complement component C5 Complement component C5a Corpus callosum Corpus Callosum - drug effects Corpus Callosum - pathology Cytokines Deposition Ecology and Environmental Sciences Epidemiology Exposure Gerontology Humans Inflammation Inflammation - chemically induced Inflammation - genetics Inflammation - physiopathology Laboratory animals Males Medicine Medicine and Health Sciences Mice Microglia Microglia - drug effects Microglia - metabolism Multiple sclerosis Nanoparticles Nanoparticles - adverse effects Neurocognitive Disorders - chemically induced Neurocognitive Disorders - genetics Neurocognitive Disorders - physiopathology Neurosciences Outdoor air quality Oxidative stress Oxidative Stress - drug effects Particulate emissions Particulate matter Particulate Matter - adverse effects Particulates Pathogenesis Physical Sciences Pollution Pollution effects Proteins Research and analysis methods Rodents Stroke Substantia alba Vehicle emissions |
| title | Nanoparticulate matter exposure results in neuroinflammatory changes in the corpus callosum |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-02T11%3A53%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Nanoparticulate%20matter%20exposure%20results%20in%20neuroinflammatory%20changes%20in%20the%20corpus%20callosum&rft.jtitle=PloS%20one&rft.au=Babadjouni,%20Robin&rft.date=2018-11-05&rft.volume=13&rft.issue=11&rft.spage=e0206934&rft.pages=e0206934-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0206934&rft_dat=%3Cproquest_plos_%3E2130050514%3C/proquest_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2130050514&rft_id=info:pmid/30395590&rft_doaj_id=oai_doaj_org_article_1d52bae5e218486799926417ada22e48&rfr_iscdi=true |