Characterization of immunogenicity of avian influenza antigens encapsulated in PLGA nanoparticles following mucosal and subcutaneous delivery in chickens

Mucosal vaccine delivery systems have paramount importance for the induction of mucosal antibody responses. Two studies were conducted to evaluate immunogenicity of inactivated AIV antigens encapsulated in poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles (NPs). In the first study, seven groups of...

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Veröffentlicht in:	PloS one 2018-11, Vol.13 (11), p.e0206324-e0206324
Hauptverfasser:	Alkie, Tamiru Negash, Yitbarek, Alexander, Taha-Abdelaziz, Khaled, Astill, Jake, Sharif, Shayan
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antigens Avian flu Biology and Life Sciences Chickens Chitosan Coatings CpG islands Delivery systems Drug delivery systems Encapsulation Formulations Hemagglutination Immune response Immunity Immunization Immunogenicity Immunoglobulin A Immunoglobulin G Mannan Medicine and Health Sciences Mucosal immunity Nanoparticles Oligonucleotides Pathogens Polylactide-co-glycolide Poultry Respiratory diseases Secretions Specific pathogen free Vaccination Vaccines Veterinary colleges Viruses
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