Genetics of the thrombomodulin-endothelial cell protein C receptor system and the risk of early-onset ischemic stroke

Polymorphisms in coagulation genes have been associated with early-onset ischemic stroke. Here we pursue an a priori hypothesis that genetic variation in the endothelial-based receptors of the thrombomodulin-protein C system (THBD and PROCR) may similarly be associated with early-onset ischemic stro...

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Veröffentlicht in:	PloS one 2018-11, Vol.13 (11), p.e0206554
Hauptverfasser:	Cole, John W, Xu, Huichun, Ryan, Kathleen, Jaworek, Thomas, Dueker, Nicole, McArdle, Patrick, Gaynor, Brady, Cheng, Yu-Ching, O'Connell, Jeffrey, Bevan, Steve, Malik, Rainer, Ahmed, Naveed Uddin, Amouyel, Philippe, Anjum, Sheraz, Bis, Joshua C, Crosslin, David, Danesh, John, Engelter, Stefan T, Fornage, Myriam, Frossard, Philippe, Gieger, Christian, Giese, Anne-Katrin, Grond-Ginsbach, Caspar, Ho, Weang Kee, Holliday, Elizabeth, Hopewell, Jemma, Hussain, M, Iqbal, W, Jabeen, S, Jannes, Jim, Kamal, Ayeesha, Kamatani, Yoichiro, Kanse, Sandip, Kloss, Manja, Lathrop, Mark, Leys, Didier, Lindgren, Arne, Longstreth, Jr, W T, Mahmood, Khalid, Meisinger, Christa, Metso, Tiina M, Mosley, Jr, Thomas, Müller-Nurasyid, Martina, Norrving, Bo, Parati, Eugenio, Peters, Annette, Pezzini, Alessandro, Quereshi, I, Rasheed, Asif, Rauf, A, Salam, T, Shen, Jess, Słowik, Agnieszka, Stanne, Tara, Strauch, Konstantin, Tatlisumak, Turgut, Thijs, Vincent N, Tiedt, Steffen, Traylor, Matthew, Waldenberger, Melanie, Walters, Matthew, Zhao, Wei, Boncoraglio, Giorgio, Debette, Stéphanie, Jern, Christina, Levi, Christopher, Markus, Hugh, Meschia, James, Rolfs, Arndt, Rothwell, Peter, Saleheen, Danish, Seshadri, Sudha, Sharma, Pankaj, Sudlow, Cathie, Worrall, Bradford, Stine, O Colin, Kittner, Steven J, Mitchell, Braxton D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult African Americans Age Age composition Age of Onset Biology and Life Sciences Black or African American - genetics Brain Ischemia Brain Ischemia - epidemiology Brain Ischemia - genetics Cardiovascular disease Case-Control Studies Clinical Medicine Coagulation Endothelial cells Endothelial Protein C Receptor Endothelial Protein C Receptor - genetics epidemiology European Continental Ancestry Group Female Genetic Association Studies Genetic diversity Genetic Predisposition to Disease Genetics Genomes Health risk assessment Health risks Heart attacks Hospitals Humans Ischemia Klinisk medicin Life Sciences Male Medical and Health Sciences Medicin och hälsovetenskap Medicine Medicine and Health Sciences Middle Aged Minority & ethnic groups Neurologi Neurology People and places Polymorphism Polymorphism, Single Nucleotide Population studies Protein C Proteins Pruning Receptors Replication Risk analysis Risk factors Single Nucleotide Single-nucleotide polymorphism Social Sciences Stroke Stroke - epidemiology Stroke - genetics Thrombomodulin Thrombomodulin - genetics White People - genetics Young Adult
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