Comparison of enteroendocrine cells and pancreatic β-cells using gene expression profiling and insulin gene methylation

Various subtypes of enteroendocrine cells (EECs) are present in the gut epithelium. EECs and pancreatic β-cells share similar pathways of differentiation during embryonic development and after birth. In this study, similarities between EECs and β-cells were evaluated in detail. To obtain specific su...

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Veröffentlicht in:	PloS one 2018-10, Vol.13 (10), p.e0206401-e0206401
Hauptverfasser:	Ryu, Gyeong Ryul, Lee, Esder, Kim, Jong Jin, Moon, Sung-Dae, Ko, Seung-Hyun, Ahn, Yu-Bae, Song, Ki-Ho
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biology and Life Sciences Cell growth Cell Line Cholecystokinin Cloning Cytosine Diabetes Diabetes mellitus Diabetes mellitus (insulin dependent) DNA Methylation DNA microarrays Embryogenesis Embryonic growth stage Endocrinology Enteroendocrine Cells - metabolism Epithelium Flow cytometry Gastrin Gene expression Gene Expression Profiling GIP protein Glucagon Glucagon-like peptide 1 Glucose Guanosine Hormones Insulin Insulin - genetics Insulin secretion Insulin-Secreting Cells - metabolism Internal medicine Medicine Medicine and Health Sciences Metabolism Mice Nkx6.1 protein Pancreas Polymerase chain reaction Proteins Research and Analysis Methods Rodents Secretin Stem cells Transcription factors Transcription Factors - genetics Transgenic animals
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