MR-based spatial normalization improves [18F]MNI-659 PET regional quantification and detectability of disease effect in the Q175 mouse model of Huntington's disease

The positron emission tomography (PET) tracer [18F]MNI-659, selective for phosphodiesterase 10A (PDE10A), is a promising tool to assess an early biomarker for Huntington's disease (HD). In this study we investigated [18F]MNI-659 uptake in the Q175 mouse model of HD. Given the focal striatal dis...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2018-10, Vol.13 (10), p.e0206613-e0206613
Hauptverfasser:	Bertoglio, Daniele, Verhaeghe, Jeroen, Kosten, Lauren, Thomae, David, Van der Linden, Annemie, Stroobants, Sigrid, Wityak, John, Dominguez, Celia, Mrzljak, Ladislav, Staelens, Steven
Format:	Artikel
Sprache:	eng
Schlagworte:	Accuracy Atrophy Biology and Life Sciences Biomarkers Brain CAT scans Comparative analysis Computed tomography Development and progression Diagnosis Fluorine isotopes Huntington's disease Huntingtons disease Image acquisition Magnetic resonance Magnetic resonance imaging Medical imaging Medicine and Health Sciences Methods Mice Mouse devices Neostriatum Neuroimaging Neuropathology NMR Nuclear magnetic resonance Nuclear medicine Phosphodiesterase Positron emission Positron emission tomography Registration Research and Analysis Methods Rodents Tomography Tracers (Biology)
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!