A methyl-sensitive element induces bidirectional transcription in TATA-less CpG island-associated promoters

How TATA-less promoters such as those within CpG islands (CGI) control gene expression is still a subject of active research. Here, we have identified the "CGCG element", a ten-base pair motif with a consensus sequence of TCTCGCGAGA present in a group of promoter-associated CGI-enriched in...

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Veröffentlicht in:	PloS one 2018-10, Vol.13 (10), p.e0205608-e0205608
Hauptverfasser:	Mahpour, Amin, Scruggs, Benjamin S, Smiraglia, Dominic, Ouchi, Toru, Gelman, Irwin H
Format:	Artikel
Sprache:	eng
Schlagworte:	Biology and life sciences Cancer Cloning Conserved sequence CpG islands Deoxyribonuclease Deoxyribonucleic acid DNA DNA methylation DNA-directed RNA polymerase Gene expression Genomes Genomics Metabolism Promoters Proteins Research and Analysis Methods Ribonucleic acid RNA RNA polymerase RNA polymerase II RNA polymerases Transcription Transcription factors Vertebrates
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