In vitro toxicity and efficacy of verdinexor, an exportin 1 inhibitor, on opportunistic viruses affecting immunocompromised individuals

Infection of immunocompromised individuals with normally benign opportunistic viruses is a major health burden globally. Infections with viruses such as Epstein-Barr virus (EBV), human cytomegalovirus (HCMV), Kaposi's sarcoma virus (KSHV), adenoviruses (AdV), BK virus (BKPyV), John Cunningham v...

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Veröffentlicht in:	PloS one 2018-10, Vol.13 (10), p.e0200043
Hauptverfasser:	Widman, Douglas G, Gornisiewicz, Savanna, Shacham, Sharon, Tamir, Sharon
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylamides - pharmacology Adaptive immunity Adenoviridae Infections - drug therapy Adenoviruses Animals Antiviral agents Apoptosis Bioavailability Biology and Life Sciences Care and treatment Cell cycle Cell Line, Tumor Cytokines Cytomegalovirus Cytomegalovirus Infections - drug therapy Dependence Drug dosages Drug Evaluation, Preclinical Epstein-Barr virus Epstein-Barr Virus Infections - drug therapy Exportin 1 Protein Exports Fibroblasts - virology Guinea Pigs Health aspects Health care HEK293 Cells HeLa Cells Histamine HIV HIV infections HIV Infections - complications HIV patients Human immunodeficiency virus Human papillomavirus Humans Hydrazines - pharmacology Immune response Immune system Immunocompromised Host - drug effects Infections Infectious diseases Inflammation Inhibitors Karyopherins - antagonists & inhibitors Kinases Medicine and Health Sciences Messenger RNA Mice Morbidity Neuropathology Nuclear engineering Nuclear safety Nuclear transport Nuclei (cytology) Papillomavirus Infections - drug therapy Polyomavirus Infections - drug therapy Protein transport Proteins Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors Reorganization and restructuring Reproducibility of Results Retention Sarcoma Sarcoma, Kaposi - drug therapy T cells Toxicity Toxicology Tumor Virus Infections - drug therapy Vaccination Viral infections Virology Virus Diseases - complications Virus Diseases - drug therapy Viruses
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