Genetics and sex influence peripheral and central innate immune responses and blood-brain barrier integrity

Lipopolysaccharide (LPS) is a stimulator of the innate immune system and is routinely used in animal models to study blood-brain barrier (BBB) dysfunction under inflammatory conditions. It is appreciated that both humans and mice have sexually dimorphic immune responses, which could influence the br...

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Veröffentlicht in:	PloS one 2018-10, Vol.13 (10), p.e0205769-e0205769
Hauptverfasser:	Erickson, Michelle A, Liang, W Sandy, Fernandez, Elizabeth G, Bullock, Kristin M, Thysell, Jarl A, Banks, William A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Biology and Life Sciences Blood-brain barrier Brain research Chemokines Convulsions & seizures Cytokines Disruption Education Endothelium Females Gender differences Genetic aspects Genetics Geriatrics Gerontology Health aspects Health care policy House mouse Immune response Immune system Inflammation Influence Injection Innate immunity Laboratory animals Lipopolysaccharides Males Medicine Medicine and Health Sciences Mice Physiology Research and Analysis Methods Rodents Sepsis Sex Sexual dimorphism Stimulators
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