Risk factors associated with inadequate control of disease activity in elderly patients with rheumatoid arthritis: Results from a nationwide KOrean College of Rheumatology BIOlogics (KOBIO) registry
The proportion of elderly patients with rheumatoid arthritis (RA) is continuously growing as a result of the increasing aging population. We compared disease activity between different age groups, and evaluated the clinical factors associated with high disease activity. This cross-sectional study an...
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| description | The proportion of elderly patients with rheumatoid arthritis (RA) is continuously growing as a result of the increasing aging population. We compared disease activity between different age groups, and evaluated the clinical factors associated with high disease activity.
This cross-sectional study analyzed the data of RA patients enrolled in the Korean College of Rheumatology Biologics registry (KOBIO-RA) between 2012 and 2014. Disease activity between elderly (age ≥ 65 years) and non-elderly patients (age < 65 years) was compared, and the association of clinical factors with high disease activity was assessed using a multivariate logistic regression model.
Of 1,227 patients in KOBIO-RA, 244 patients with RA were aged 65 years or over. In elderly patients, the proportion of men was higher (P = 0.012), and the duration of disease was longer (P < 0.001) compared with non-elderly patients. The elderly group showed a higher incidence of comorbidity (P < 0.001), and less use of methotrexate (P = 0.004). Assessment of disease activity using various composite measures showed a higher proportion of high disease activity in elderly patients than non-elderly patients. Longer disease duration, presence of comorbidity, and non-use of methotrexate were independently associated with high disease activity (P = 0.002, P < 0.001, and P = 0.029, respectively).
At enrollment of KOBIO-RA, elderly patients showed higher disease activity compared with non-elderly patients. Disease duration, use of methotrexate, and comorbidity are associated with disease activity control in Korean patients with RA. |
| doi_str_mv | 10.1371/journal.pone.0205651 |
| format | Article |
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This cross-sectional study analyzed the data of RA patients enrolled in the Korean College of Rheumatology Biologics registry (KOBIO-RA) between 2012 and 2014. Disease activity between elderly (age ≥ 65 years) and non-elderly patients (age < 65 years) was compared, and the association of clinical factors with high disease activity was assessed using a multivariate logistic regression model.
Of 1,227 patients in KOBIO-RA, 244 patients with RA were aged 65 years or over. In elderly patients, the proportion of men was higher (P = 0.012), and the duration of disease was longer (P < 0.001) compared with non-elderly patients. The elderly group showed a higher incidence of comorbidity (P < 0.001), and less use of methotrexate (P = 0.004). Assessment of disease activity using various composite measures showed a higher proportion of high disease activity in elderly patients than non-elderly patients. Longer disease duration, presence of comorbidity, and non-use of methotrexate were independently associated with high disease activity (P = 0.002, P < 0.001, and P = 0.029, respectively).
At enrollment of KOBIO-RA, elderly patients showed higher disease activity compared with non-elderly patients. Disease duration, use of methotrexate, and comorbidity are associated with disease activity control in Korean patients with RA.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0205651</identifier><identifier>PMID: 30325962</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age ; Aging ; Arthritis ; Biology and Life Sciences ; Care and treatment ; Clinical outcomes ; Data processing ; Diabetes ; Disability ; Disease control ; Elderly patients ; Exercise ; Geriatrics ; Health aspects ; Health risk assessment ; Health risks ; Internal medicine ; Medicine ; Medicine and Health Sciences ; Methotrexate ; Older people ; Patients ; People and Places ; Regression analysis ; Regression models ; Rheumatoid arthritis ; Rheumatology ; Risk analysis ; Risk factors ; Studies ; Tumor necrosis factor-TNF</subject><ispartof>PloS one, 2018-10, Vol.13 (10), p.e0205651</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Jung et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 Jung et al 2018 Jung et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c593t-df7cda1164326a12544d07fd55f12c0c80e494a0e2467ea250cca48680713d703</citedby><cites>FETCH-LOGICAL-c593t-df7cda1164326a12544d07fd55f12c0c80e494a0e2467ea250cca48680713d703</cites><orcidid>0000-0003-1711-2060</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191131/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191131/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27903,27904,53769,53771,79346,79347</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30325962$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Margiotta, Domenico Paolo Emanuele</contributor><creatorcontrib>Jung, Seung Min</creatorcontrib><creatorcontrib>Kwok, Seung-Ki</creatorcontrib><creatorcontrib>Ju, Ji Hyeon</creatorcontrib><creatorcontrib>Lee, Sang-Won</creatorcontrib><creatorcontrib>Song, Jason Jungsik</creatorcontrib><creatorcontrib>Yoon, Chong-Hyeon</creatorcontrib><creatorcontrib>Park, Yong-Beom</creatorcontrib><creatorcontrib>Park, Sung-Hwan</creatorcontrib><title>Risk factors associated with inadequate control of disease activity in elderly patients with rheumatoid arthritis: Results from a nationwide KOrean College of Rheumatology BIOlogics (KOBIO) registry</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The proportion of elderly patients with rheumatoid arthritis (RA) is continuously growing as a result of the increasing aging population. We compared disease activity between different age groups, and evaluated the clinical factors associated with high disease activity.
This cross-sectional study analyzed the data of RA patients enrolled in the Korean College of Rheumatology Biologics registry (KOBIO-RA) between 2012 and 2014. Disease activity between elderly (age ≥ 65 years) and non-elderly patients (age < 65 years) was compared, and the association of clinical factors with high disease activity was assessed using a multivariate logistic regression model.
Of 1,227 patients in KOBIO-RA, 244 patients with RA were aged 65 years or over. In elderly patients, the proportion of men was higher (P = 0.012), and the duration of disease was longer (P < 0.001) compared with non-elderly patients. The elderly group showed a higher incidence of comorbidity (P < 0.001), and less use of methotrexate (P = 0.004). Assessment of disease activity using various composite measures showed a higher proportion of high disease activity in elderly patients than non-elderly patients. Longer disease duration, presence of comorbidity, and non-use of methotrexate were independently associated with high disease activity (P = 0.002, P < 0.001, and P = 0.029, respectively).
At enrollment of KOBIO-RA, elderly patients showed higher disease activity compared with non-elderly patients. Disease duration, use of methotrexate, and comorbidity are associated with disease activity control in Korean patients with RA.</description><subject>Age</subject><subject>Aging</subject><subject>Arthritis</subject><subject>Biology and Life Sciences</subject><subject>Care and treatment</subject><subject>Clinical outcomes</subject><subject>Data processing</subject><subject>Diabetes</subject><subject>Disability</subject><subject>Disease control</subject><subject>Elderly patients</subject><subject>Exercise</subject><subject>Geriatrics</subject><subject>Health aspects</subject><subject>Health risk assessment</subject><subject>Health risks</subject><subject>Internal medicine</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Methotrexate</subject><subject>Older people</subject><subject>Patients</subject><subject>People and Places</subject><subject>Regression analysis</subject><subject>Regression models</subject><subject>Rheumatoid 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factors associated with inadequate control of disease activity in elderly patients with rheumatoid arthritis: Results from a nationwide KOrean College of Rheumatology BIOlogics (KOBIO) registry</title><author>Jung, Seung Min ; Kwok, Seung-Ki ; Ju, Ji Hyeon ; Lee, Sang-Won ; Song, Jason Jungsik ; Yoon, Chong-Hyeon ; Park, Yong-Beom ; Park, Sung-Hwan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c593t-df7cda1164326a12544d07fd55f12c0c80e494a0e2467ea250cca48680713d703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Age</topic><topic>Aging</topic><topic>Arthritis</topic><topic>Biology and Life Sciences</topic><topic>Care and treatment</topic><topic>Clinical outcomes</topic><topic>Data processing</topic><topic>Diabetes</topic><topic>Disability</topic><topic>Disease control</topic><topic>Elderly patients</topic><topic>Exercise</topic><topic>Geriatrics</topic><topic>Health aspects</topic><topic>Health risk assessment</topic><topic>Health risks</topic><topic>Internal medicine</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Methotrexate</topic><topic>Older people</topic><topic>Patients</topic><topic>People and Places</topic><topic>Regression analysis</topic><topic>Regression models</topic><topic>Rheumatoid arthritis</topic><topic>Rheumatology</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Studies</topic><topic>Tumor necrosis factor-TNF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jung, Seung Min</creatorcontrib><creatorcontrib>Kwok, Seung-Ki</creatorcontrib><creatorcontrib>Ju, Ji Hyeon</creatorcontrib><creatorcontrib>Lee, Sang-Won</creatorcontrib><creatorcontrib>Song, Jason Jungsik</creatorcontrib><creatorcontrib>Yoon, Chong-Hyeon</creatorcontrib><creatorcontrib>Park, Yong-Beom</creatorcontrib><creatorcontrib>Park, 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registry</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2018-10-16</date><risdate>2018</risdate><volume>13</volume><issue>10</issue><spage>e0205651</spage><pages>e0205651-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The proportion of elderly patients with rheumatoid arthritis (RA) is continuously growing as a result of the increasing aging population. We compared disease activity between different age groups, and evaluated the clinical factors associated with high disease activity.
This cross-sectional study analyzed the data of RA patients enrolled in the Korean College of Rheumatology Biologics registry (KOBIO-RA) between 2012 and 2014. Disease activity between elderly (age ≥ 65 years) and non-elderly patients (age < 65 years) was compared, and the association of clinical factors with high disease activity was assessed using a multivariate logistic regression model.
Of 1,227 patients in KOBIO-RA, 244 patients with RA were aged 65 years or over. In elderly patients, the proportion of men was higher (P = 0.012), and the duration of disease was longer (P < 0.001) compared with non-elderly patients. The elderly group showed a higher incidence of comorbidity (P < 0.001), and less use of methotrexate (P = 0.004). Assessment of disease activity using various composite measures showed a higher proportion of high disease activity in elderly patients than non-elderly patients. Longer disease duration, presence of comorbidity, and non-use of methotrexate were independently associated with high disease activity (P = 0.002, P < 0.001, and P = 0.029, respectively).
At enrollment of KOBIO-RA, elderly patients showed higher disease activity compared with non-elderly patients. Disease duration, use of methotrexate, and comorbidity are associated with disease activity control in Korean patients with RA.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>30325962</pmid><doi>10.1371/journal.pone.0205651</doi><orcidid>https://orcid.org/0000-0003-1711-2060</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Age Aging Arthritis Biology and Life Sciences Care and treatment Clinical outcomes Data processing Diabetes Disability Disease control Elderly patients Exercise Geriatrics Health aspects Health risk assessment Health risks Internal medicine Medicine Medicine and Health Sciences Methotrexate Older people Patients People and Places Regression analysis Regression models Rheumatoid arthritis Rheumatology Risk analysis Risk factors Studies Tumor necrosis factor-TNF |
| title | Risk factors associated with inadequate control of disease activity in elderly patients with rheumatoid arthritis: Results from a nationwide KOrean College of Rheumatology BIOlogics (KOBIO) registry |
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