The prognostic value of prognostic nutritional index in hepatocellular carcinoma patients: A meta-analysis of observational studies
The clinical value of the prognostic nutritional index (PNI) in hepatocellular carcinoma (HCC) has been investigated in previous studies, but the results remain controversial. Here we present a meta-analysis to systematically review the association between PNI and HCC prognosis. PubMed, EMBASE, Web...
Gespeichert in:
| Veröffentlicht in: | PloS one 2018-10, Vol.13 (10), p.e0202987-e0202987 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e0202987 |
|---|---|
| container_issue | 10 |
| container_start_page | e0202987 |
| container_title | PloS one |
| container_volume | 13 |
| creator | Wang, Zhiling Wang, Jie Wang, Peijun |
| description | The clinical value of the prognostic nutritional index (PNI) in hepatocellular carcinoma (HCC) has been investigated in previous studies, but the results remain controversial. Here we present a meta-analysis to systematically review the association between PNI and HCC prognosis.
PubMed, EMBASE, Web of Science databases were systematically searched to identify relevant studies. Data were abstracted independently by two reviewers. A meta-analysis was performed to determine the prognostic and clinic-pathological values of PNI in HCC patients. Odds ratios (ORs) and 95% confidence intervals (CIs) were extracted to estimate the association of PNI with survival and clinic-pathological characteristics, respectively.
A total of eleven studies involving 3165 patients were analyzed. The pooled results indicated that low PNI is a significant predictor of poor 1-year, 3-year, 5-year OS (OR, 2.91, 4.05, 3.65; 95%CI, 2.30 to 3.70, 3.27 to 5.03,2.96-4.50; P = 0.14,0.22,0.11 respectively) and disease-free survival (DFS) (OR,2.35, 2.57, 2.75; 95%CI, 1.71 to 3.23, 1.89 to 3.49,2.01 to 3.75; P = 0.39,0.04,0.11, respectively). Moreover, PNI is significantly associated with serum AFP, tumor recurrence, tumor size and TNM stages in HCC patients. However, PNI is not significantly associated with tumor number and the incidence of cirrhosis in HCC patients.
PNI is an independent predictive indicator of survival and associated with serum AFP, tumor recurrence, tumor size and TNM stages in HCC patients. |
| doi_str_mv | 10.1371/journal.pone.0202987 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2118793759</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A559617816</galeid><doaj_id>oai_doaj_org_article_58e114447ee240fbb6e4087e236ee6c6</doaj_id><sourcerecordid>A559617816</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-47ad81bdce25371cc84ae2799c42a97c461f1e1ec0e5ce09dea85c7f3283e3ae3</originalsourceid><addsrcrecordid>eNqNk12L1DAUhoso7jr6D0QLgujFjPlom8YLYVj8GFhY0NXbcCY9ncnSNmOSDrvX_nHTne4ylb2QQhtOn_Oekzc5SfKSkgXlgn64sr3roFnsbIcLwgiTpXiUnFLJ2bxghD8-Wp8kz7y_IiTnZVE8TU444ZQxmZ8mfy63mO6c3XTWB6PTPTQ9prY-jnV9cCYYG6ulpqvwOr7TLe4gWI1N0zfgUg1Om862kMawwS74j-kybTHAHGLejTd-ULVrj24Po5gPfWXQP0-e1NB4fDF-Z8nPL58vz77Nzy--rs6W53NdSBbmmYCqpOtKI8ujAVqXGSATUuqMgRQ6K2hNkaImmGskskIocy1qzkqOHJDPktcH3V1jvRr984pRWgrJRS4jsToQlYUrtXOmBXejLBh1G7Buo8BFSxpUeYmUZlkmEFlG6vW6wIyUAhkvEAtdRK1PY7V-3WLsugsOmono9E9ntmpj96qgZS7ioc2Sd6OAs7979EG1xg-GQ4e2v-1bSiYymkf0zT_ow7sbqQ3EDZiutrGuHkTVMs9lQUVJh74XD1DxqbA1Ol622sT4JOH9JCEyAa_DBnrv1erH9_9nL35N2bdH7BahCVtvm364PH4KZgdQO-u9w_reZErUMCt3bqhhVtQ4KzHt1fEB3SfdDQf_CzxXEhY</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2118793759</pqid></control><display><type>article</type><title>The prognostic value of prognostic nutritional index in hepatocellular carcinoma patients: A meta-analysis of observational studies</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Public Library of Science (PLoS) Journals Open Access</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Wang, Zhiling ; Wang, Jie ; Wang, Peijun</creator><contributor>Bonino, Ferruccio</contributor><creatorcontrib>Wang, Zhiling ; Wang, Jie ; Wang, Peijun ; Bonino, Ferruccio</creatorcontrib><description>The clinical value of the prognostic nutritional index (PNI) in hepatocellular carcinoma (HCC) has been investigated in previous studies, but the results remain controversial. Here we present a meta-analysis to systematically review the association between PNI and HCC prognosis.
PubMed, EMBASE, Web of Science databases were systematically searched to identify relevant studies. Data were abstracted independently by two reviewers. A meta-analysis was performed to determine the prognostic and clinic-pathological values of PNI in HCC patients. Odds ratios (ORs) and 95% confidence intervals (CIs) were extracted to estimate the association of PNI with survival and clinic-pathological characteristics, respectively.
A total of eleven studies involving 3165 patients were analyzed. The pooled results indicated that low PNI is a significant predictor of poor 1-year, 3-year, 5-year OS (OR, 2.91, 4.05, 3.65; 95%CI, 2.30 to 3.70, 3.27 to 5.03,2.96-4.50; P = 0.14,0.22,0.11 respectively) and disease-free survival (DFS) (OR,2.35, 2.57, 2.75; 95%CI, 1.71 to 3.23, 1.89 to 3.49,2.01 to 3.75; P = 0.39,0.04,0.11, respectively). Moreover, PNI is significantly associated with serum AFP, tumor recurrence, tumor size and TNM stages in HCC patients. However, PNI is not significantly associated with tumor number and the incidence of cirrhosis in HCC patients.
PNI is an independent predictive indicator of survival and associated with serum AFP, tumor recurrence, tumor size and TNM stages in HCC patients.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0202987</identifier><identifier>PMID: 30312295</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Biology and Life Sciences ; Cancer patients ; Carcinoma, Hepatocellular - diagnosis ; Carcinoma, Hepatocellular - physiopathology ; Children & youth ; Cirrhosis ; Confidence intervals ; Disease-Free Survival ; Female ; Fibrosis - diagnosis ; Fibrosis - physiopathology ; Food and nutrition ; Health aspects ; Hepatectomy ; Hepatitis ; Hepatocellular carcinoma ; Hepatology ; Hospitals ; Humans ; Inflammation ; Liver cancer ; Liver cirrhosis ; Liver Neoplasms - diagnosis ; Liver Neoplasms - physiopathology ; Lymphocytes ; Male ; Medical ethics ; Medical prognosis ; Medicine and Health Sciences ; Meta-analysis ; Metastasis ; Neoplasm Metastasis ; Neoplasm Staging ; Nutrition ; Nutrition Assessment ; Nutritional requirements ; Observational studies ; Patients ; Physical Sciences ; Prognosis ; Research and Analysis Methods ; Science Policy ; Studies ; Surgery ; Survival ; Tumors</subject><ispartof>PloS one, 2018-10, Vol.13 (10), p.e0202987-e0202987</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 Wang et al 2018 Wang et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-47ad81bdce25371cc84ae2799c42a97c461f1e1ec0e5ce09dea85c7f3283e3ae3</citedby><cites>FETCH-LOGICAL-c692t-47ad81bdce25371cc84ae2799c42a97c461f1e1ec0e5ce09dea85c7f3283e3ae3</cites><orcidid>0000-0002-9428-9241</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185720/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185720/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30312295$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Bonino, Ferruccio</contributor><creatorcontrib>Wang, Zhiling</creatorcontrib><creatorcontrib>Wang, Jie</creatorcontrib><creatorcontrib>Wang, Peijun</creatorcontrib><title>The prognostic value of prognostic nutritional index in hepatocellular carcinoma patients: A meta-analysis of observational studies</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The clinical value of the prognostic nutritional index (PNI) in hepatocellular carcinoma (HCC) has been investigated in previous studies, but the results remain controversial. Here we present a meta-analysis to systematically review the association between PNI and HCC prognosis.
PubMed, EMBASE, Web of Science databases were systematically searched to identify relevant studies. Data were abstracted independently by two reviewers. A meta-analysis was performed to determine the prognostic and clinic-pathological values of PNI in HCC patients. Odds ratios (ORs) and 95% confidence intervals (CIs) were extracted to estimate the association of PNI with survival and clinic-pathological characteristics, respectively.
A total of eleven studies involving 3165 patients were analyzed. The pooled results indicated that low PNI is a significant predictor of poor 1-year, 3-year, 5-year OS (OR, 2.91, 4.05, 3.65; 95%CI, 2.30 to 3.70, 3.27 to 5.03,2.96-4.50; P = 0.14,0.22,0.11 respectively) and disease-free survival (DFS) (OR,2.35, 2.57, 2.75; 95%CI, 1.71 to 3.23, 1.89 to 3.49,2.01 to 3.75; P = 0.39,0.04,0.11, respectively). Moreover, PNI is significantly associated with serum AFP, tumor recurrence, tumor size and TNM stages in HCC patients. However, PNI is not significantly associated with tumor number and the incidence of cirrhosis in HCC patients.
PNI is an independent predictive indicator of survival and associated with serum AFP, tumor recurrence, tumor size and TNM stages in HCC patients.</description><subject>Analysis</subject><subject>Biology and Life Sciences</subject><subject>Cancer patients</subject><subject>Carcinoma, Hepatocellular - diagnosis</subject><subject>Carcinoma, Hepatocellular - physiopathology</subject><subject>Children & youth</subject><subject>Cirrhosis</subject><subject>Confidence intervals</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Fibrosis - diagnosis</subject><subject>Fibrosis - physiopathology</subject><subject>Food and nutrition</subject><subject>Health aspects</subject><subject>Hepatectomy</subject><subject>Hepatitis</subject><subject>Hepatocellular carcinoma</subject><subject>Hepatology</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Liver cancer</subject><subject>Liver cirrhosis</subject><subject>Liver Neoplasms - diagnosis</subject><subject>Liver Neoplasms - physiopathology</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>Medical ethics</subject><subject>Medical prognosis</subject><subject>Medicine and Health Sciences</subject><subject>Meta-analysis</subject><subject>Metastasis</subject><subject>Neoplasm Metastasis</subject><subject>Neoplasm Staging</subject><subject>Nutrition</subject><subject>Nutrition Assessment</subject><subject>Nutritional requirements</subject><subject>Observational studies</subject><subject>Patients</subject><subject>Physical Sciences</subject><subject>Prognosis</subject><subject>Research and Analysis Methods</subject><subject>Science Policy</subject><subject>Studies</subject><subject>Surgery</subject><subject>Survival</subject><subject>Tumors</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk12L1DAUhoso7jr6D0QLgujFjPlom8YLYVj8GFhY0NXbcCY9ncnSNmOSDrvX_nHTne4ylb2QQhtOn_Oekzc5SfKSkgXlgn64sr3roFnsbIcLwgiTpXiUnFLJ2bxghD8-Wp8kz7y_IiTnZVE8TU444ZQxmZ8mfy63mO6c3XTWB6PTPTQ9prY-jnV9cCYYG6ulpqvwOr7TLe4gWI1N0zfgUg1Om862kMawwS74j-kybTHAHGLejTd-ULVrj24Po5gPfWXQP0-e1NB4fDF-Z8nPL58vz77Nzy--rs6W53NdSBbmmYCqpOtKI8ujAVqXGSATUuqMgRQ6K2hNkaImmGskskIocy1qzkqOHJDPktcH3V1jvRr984pRWgrJRS4jsToQlYUrtXOmBXejLBh1G7Buo8BFSxpUeYmUZlkmEFlG6vW6wIyUAhkvEAtdRK1PY7V-3WLsugsOmono9E9ntmpj96qgZS7ioc2Sd6OAs7979EG1xg-GQ4e2v-1bSiYymkf0zT_ow7sbqQ3EDZiutrGuHkTVMs9lQUVJh74XD1DxqbA1Ol622sT4JOH9JCEyAa_DBnrv1erH9_9nL35N2bdH7BahCVtvm364PH4KZgdQO-u9w_reZErUMCt3bqhhVtQ4KzHt1fEB3SfdDQf_CzxXEhY</recordid><startdate>20181012</startdate><enddate>20181012</enddate><creator>Wang, Zhiling</creator><creator>Wang, Jie</creator><creator>Wang, Peijun</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-9428-9241</orcidid></search><sort><creationdate>20181012</creationdate><title>The prognostic value of prognostic nutritional index in hepatocellular carcinoma patients: A meta-analysis of observational studies</title><author>Wang, Zhiling ; Wang, Jie ; Wang, Peijun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-47ad81bdce25371cc84ae2799c42a97c461f1e1ec0e5ce09dea85c7f3283e3ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Analysis</topic><topic>Biology and Life Sciences</topic><topic>Cancer patients</topic><topic>Carcinoma, Hepatocellular - diagnosis</topic><topic>Carcinoma, Hepatocellular - physiopathology</topic><topic>Children & youth</topic><topic>Cirrhosis</topic><topic>Confidence intervals</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Fibrosis - diagnosis</topic><topic>Fibrosis - physiopathology</topic><topic>Food and nutrition</topic><topic>Health aspects</topic><topic>Hepatectomy</topic><topic>Hepatitis</topic><topic>Hepatocellular carcinoma</topic><topic>Hepatology</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Liver cancer</topic><topic>Liver cirrhosis</topic><topic>Liver Neoplasms - diagnosis</topic><topic>Liver Neoplasms - physiopathology</topic><topic>Lymphocytes</topic><topic>Male</topic><topic>Medical ethics</topic><topic>Medical prognosis</topic><topic>Medicine and Health Sciences</topic><topic>Meta-analysis</topic><topic>Metastasis</topic><topic>Neoplasm Metastasis</topic><topic>Neoplasm Staging</topic><topic>Nutrition</topic><topic>Nutrition Assessment</topic><topic>Nutritional requirements</topic><topic>Observational studies</topic><topic>Patients</topic><topic>Physical Sciences</topic><topic>Prognosis</topic><topic>Research and Analysis Methods</topic><topic>Science Policy</topic><topic>Studies</topic><topic>Surgery</topic><topic>Survival</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Zhiling</creatorcontrib><creatorcontrib>Wang, Jie</creatorcontrib><creatorcontrib>Wang, Peijun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Zhiling</au><au>Wang, Jie</au><au>Wang, Peijun</au><au>Bonino, Ferruccio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The prognostic value of prognostic nutritional index in hepatocellular carcinoma patients: A meta-analysis of observational studies</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2018-10-12</date><risdate>2018</risdate><volume>13</volume><issue>10</issue><spage>e0202987</spage><epage>e0202987</epage><pages>e0202987-e0202987</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The clinical value of the prognostic nutritional index (PNI) in hepatocellular carcinoma (HCC) has been investigated in previous studies, but the results remain controversial. Here we present a meta-analysis to systematically review the association between PNI and HCC prognosis.
PubMed, EMBASE, Web of Science databases were systematically searched to identify relevant studies. Data were abstracted independently by two reviewers. A meta-analysis was performed to determine the prognostic and clinic-pathological values of PNI in HCC patients. Odds ratios (ORs) and 95% confidence intervals (CIs) were extracted to estimate the association of PNI with survival and clinic-pathological characteristics, respectively.
A total of eleven studies involving 3165 patients were analyzed. The pooled results indicated that low PNI is a significant predictor of poor 1-year, 3-year, 5-year OS (OR, 2.91, 4.05, 3.65; 95%CI, 2.30 to 3.70, 3.27 to 5.03,2.96-4.50; P = 0.14,0.22,0.11 respectively) and disease-free survival (DFS) (OR,2.35, 2.57, 2.75; 95%CI, 1.71 to 3.23, 1.89 to 3.49,2.01 to 3.75; P = 0.39,0.04,0.11, respectively). Moreover, PNI is significantly associated with serum AFP, tumor recurrence, tumor size and TNM stages in HCC patients. However, PNI is not significantly associated with tumor number and the incidence of cirrhosis in HCC patients.
PNI is an independent predictive indicator of survival and associated with serum AFP, tumor recurrence, tumor size and TNM stages in HCC patients.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>30312295</pmid><doi>10.1371/journal.pone.0202987</doi><tpages>e0202987</tpages><orcidid>https://orcid.org/0000-0002-9428-9241</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2018-10, Vol.13 (10), p.e0202987-e0202987 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2118793759 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS) Journals Open Access; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Analysis Biology and Life Sciences Cancer patients Carcinoma, Hepatocellular - diagnosis Carcinoma, Hepatocellular - physiopathology Children & youth Cirrhosis Confidence intervals Disease-Free Survival Female Fibrosis - diagnosis Fibrosis - physiopathology Food and nutrition Health aspects Hepatectomy Hepatitis Hepatocellular carcinoma Hepatology Hospitals Humans Inflammation Liver cancer Liver cirrhosis Liver Neoplasms - diagnosis Liver Neoplasms - physiopathology Lymphocytes Male Medical ethics Medical prognosis Medicine and Health Sciences Meta-analysis Metastasis Neoplasm Metastasis Neoplasm Staging Nutrition Nutrition Assessment Nutritional requirements Observational studies Patients Physical Sciences Prognosis Research and Analysis Methods Science Policy Studies Surgery Survival Tumors |
| title | The prognostic value of prognostic nutritional index in hepatocellular carcinoma patients: A meta-analysis of observational studies |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-21T07%3A00%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20prognostic%20value%20of%20prognostic%20nutritional%20index%20in%20hepatocellular%20carcinoma%20patients:%20A%20meta-analysis%20of%20observational%20studies&rft.jtitle=PloS%20one&rft.au=Wang,%20Zhiling&rft.date=2018-10-12&rft.volume=13&rft.issue=10&rft.spage=e0202987&rft.epage=e0202987&rft.pages=e0202987-e0202987&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0202987&rft_dat=%3Cgale_plos_%3EA559617816%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2118793759&rft_id=info:pmid/30312295&rft_galeid=A559617816&rft_doaj_id=oai_doaj_org_article_58e114447ee240fbb6e4087e236ee6c6&rfr_iscdi=true |