The added value of whole-body magnetic resonance imaging in the management of patients with advanced breast cancer
This study investigates the impact of whole-body MRI (WB-MRI) in addition to CT of chest-abdomen-pelvis (CT-CAP) and 18F-FDG PET/CT (PET/CT) on systemic treatment decisions in standard clinical practice for patients with advanced breast cancer (ABC). WB-MRI examinations in ABC patients were extracte...
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| description | This study investigates the impact of whole-body MRI (WB-MRI) in addition to CT of chest-abdomen-pelvis (CT-CAP) and 18F-FDG PET/CT (PET/CT) on systemic treatment decisions in standard clinical practice for patients with advanced breast cancer (ABC). WB-MRI examinations in ABC patients were extracted from our WB-MRI registry (2009-2017). Patients under systemic treatment who underwent WB-MRI and a control examination (CT-CAP or PET/CT) were included. Data regarding progressive disease (PD) reported either on WB-MRI or on the control examinations were collected. Data regarding eventual change in treatment after the imaging evaluation were collected. It was finally evaluated whether the detection of PD by any of the two modalities had induced a change in treatment. Among 910 WB-MRI examinations in ABC patients, 58 had a paired control examination (16 CT-CAP and 42 PET/CT) and were analysed. In 23/58 paired examinations, additional sites of disease were reported only on WB-MRI and not on the control examination. In 17/28 paired examinations, PD was reported only on WB-MRI and not on the control examination. In 14 out of the 28 pairs of examinations that were followed by a change in treatment, PD had been reported only on WBMRI (14/28; 50%), while stable disease had been reported on the control examination. In conclusion, WB-MRI disclosed PD earlier than the control examination (CT-CAP or PET/CT), and it was responsible alone for 50% of all changes in treatment. |
| doi_str_mv | 10.1371/journal.pone.0205251 |
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WB-MRI examinations in ABC patients were extracted from our WB-MRI registry (2009-2017). Patients under systemic treatment who underwent WB-MRI and a control examination (CT-CAP or PET/CT) were included. Data regarding progressive disease (PD) reported either on WB-MRI or on the control examinations were collected. Data regarding eventual change in treatment after the imaging evaluation were collected. It was finally evaluated whether the detection of PD by any of the two modalities had induced a change in treatment. Among 910 WB-MRI examinations in ABC patients, 58 had a paired control examination (16 CT-CAP and 42 PET/CT) and were analysed. In 23/58 paired examinations, additional sites of disease were reported only on WB-MRI and not on the control examination. In 17/28 paired examinations, PD was reported only on WB-MRI and not on the control examination. In 14 out of the 28 pairs of examinations that were followed by a change in treatment, PD had been reported only on WBMRI (14/28; 50%), while stable disease had been reported on the control examination. In conclusion, WB-MRI disclosed PD earlier than the control examination (CT-CAP or PET/CT), and it was responsible alone for 50% of all changes in treatment.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0205251</identifier><identifier>PMID: 30312335</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Added value ; Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Biology and Life Sciences ; Bone Neoplasms - diagnostic imaging ; Bone Neoplasms - prevention & control ; Bone Neoplasms - secondary ; Breast - diagnostic imaging ; Breast - pathology ; Breast cancer ; Breast Neoplasms - diagnostic imaging ; Breast Neoplasms - drug therapy ; Breast Neoplasms - pathology ; Cancer ; Care and treatment ; Computed tomography ; Disease control ; Disease Progression ; Feasibility Studies ; Female ; Fluorodeoxyglucose F18 - administration & dosage ; Humans ; Magnetic resonance ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Mastectomy ; Medical imaging ; Medicine and Health Sciences ; Middle Aged ; NMR ; Nuclear magnetic resonance ; Ovarian cancer ; Patient Selection ; Patients ; Pelvis ; Positron emission ; Positron emission tomography ; Positron Emission Tomography Computed Tomography - methods ; Radiopharmaceuticals - administration & dosage ; Research and Analysis Methods ; Retrospective Studies ; Sensitivity and Specificity ; Tomography ; Treatment Outcome ; Whole Body Imaging - methods</subject><ispartof>PloS one, 2018-10, Vol.13 (10), p.e0205251-e0205251</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Zugni et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 Zugni et al 2018 Zugni et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-800f582747dfbc7ea9a996e7cbd335fd5ea7c5abe4286a8c86a79e93a18fa93e3</citedby><cites>FETCH-LOGICAL-c692t-800f582747dfbc7ea9a996e7cbd335fd5ea7c5abe4286a8c86a79e93a18fa93e3</cites><orcidid>0000-0001-9448-4760</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185838/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185838/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30312335$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zugni, Fabio</creatorcontrib><creatorcontrib>Ruju, Francesca</creatorcontrib><creatorcontrib>Pricolo, Paola</creatorcontrib><creatorcontrib>Alessi, Sarah</creatorcontrib><creatorcontrib>Iorfida, Monica</creatorcontrib><creatorcontrib>Colleoni, Marco Angelo</creatorcontrib><creatorcontrib>Bellomi, Massimo</creatorcontrib><creatorcontrib>Petralia, Giuseppe</creatorcontrib><title>The added value of whole-body magnetic resonance imaging in the management of patients with advanced breast cancer</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>This study investigates the impact of whole-body MRI (WB-MRI) in addition to CT of chest-abdomen-pelvis (CT-CAP) and 18F-FDG PET/CT (PET/CT) on systemic treatment decisions in standard clinical practice for patients with advanced breast cancer (ABC). WB-MRI examinations in ABC patients were extracted from our WB-MRI registry (2009-2017). Patients under systemic treatment who underwent WB-MRI and a control examination (CT-CAP or PET/CT) were included. Data regarding progressive disease (PD) reported either on WB-MRI or on the control examinations were collected. Data regarding eventual change in treatment after the imaging evaluation were collected. It was finally evaluated whether the detection of PD by any of the two modalities had induced a change in treatment. Among 910 WB-MRI examinations in ABC patients, 58 had a paired control examination (16 CT-CAP and 42 PET/CT) and were analysed. In 23/58 paired examinations, additional sites of disease were reported only on WB-MRI and not on the control examination. In 17/28 paired examinations, PD was reported only on WB-MRI and not on the control examination. In 14 out of the 28 pairs of examinations that were followed by a change in treatment, PD had been reported only on WBMRI (14/28; 50%), while stable disease had been reported on the control examination. In conclusion, WB-MRI disclosed PD earlier than the control examination (CT-CAP or PET/CT), and it was responsible alone for 50% of all changes in treatment.</description><subject>Added value</subject><subject>Adult</subject><subject>Aged</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Biology and Life Sciences</subject><subject>Bone Neoplasms - diagnostic imaging</subject><subject>Bone Neoplasms - prevention & control</subject><subject>Bone Neoplasms - secondary</subject><subject>Breast - diagnostic imaging</subject><subject>Breast - pathology</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - diagnostic imaging</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Breast Neoplasms - pathology</subject><subject>Cancer</subject><subject>Care and treatment</subject><subject>Computed tomography</subject><subject>Disease control</subject><subject>Disease Progression</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18 - 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WB-MRI examinations in ABC patients were extracted from our WB-MRI registry (2009-2017). Patients under systemic treatment who underwent WB-MRI and a control examination (CT-CAP or PET/CT) were included. Data regarding progressive disease (PD) reported either on WB-MRI or on the control examinations were collected. Data regarding eventual change in treatment after the imaging evaluation were collected. It was finally evaluated whether the detection of PD by any of the two modalities had induced a change in treatment. Among 910 WB-MRI examinations in ABC patients, 58 had a paired control examination (16 CT-CAP and 42 PET/CT) and were analysed. In 23/58 paired examinations, additional sites of disease were reported only on WB-MRI and not on the control examination. In 17/28 paired examinations, PD was reported only on WB-MRI and not on the control examination. In 14 out of the 28 pairs of examinations that were followed by a change in treatment, PD had been reported only on WBMRI (14/28; 50%), while stable disease had been reported on the control examination. In conclusion, WB-MRI disclosed PD earlier than the control examination (CT-CAP or PET/CT), and it was responsible alone for 50% of all changes in treatment.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>30312335</pmid><doi>10.1371/journal.pone.0205251</doi><tpages>e0205251</tpages><orcidid>https://orcid.org/0000-0001-9448-4760</orcidid><oa>free_for_read</oa></addata></record> |
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| issn | 1932-6203 1932-6203 |
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| subjects | Added value Adult Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biology and Life Sciences Bone Neoplasms - diagnostic imaging Bone Neoplasms - prevention & control Bone Neoplasms - secondary Breast - diagnostic imaging Breast - pathology Breast cancer Breast Neoplasms - diagnostic imaging Breast Neoplasms - drug therapy Breast Neoplasms - pathology Cancer Care and treatment Computed tomography Disease control Disease Progression Feasibility Studies Female Fluorodeoxyglucose F18 - administration & dosage Humans Magnetic resonance Magnetic resonance imaging Magnetic Resonance Imaging - methods Mastectomy Medical imaging Medicine and Health Sciences Middle Aged NMR Nuclear magnetic resonance Ovarian cancer Patient Selection Patients Pelvis Positron emission Positron emission tomography Positron Emission Tomography Computed Tomography - methods Radiopharmaceuticals - administration & dosage Research and Analysis Methods Retrospective Studies Sensitivity and Specificity Tomography Treatment Outcome Whole Body Imaging - methods |
| title | The added value of whole-body magnetic resonance imaging in the management of patients with advanced breast cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T06%3A21%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20added%20value%20of%20whole-body%20magnetic%20resonance%20imaging%20in%20the%20management%20of%20patients%20with%20advanced%20breast%20cancer&rft.jtitle=PloS%20one&rft.au=Zugni,%20Fabio&rft.date=2018-10-12&rft.volume=13&rft.issue=10&rft.spage=e0205251&rft.epage=e0205251&rft.pages=e0205251-e0205251&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0205251&rft_dat=%3Cgale_plos_%3EA559617803%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2118788241&rft_id=info:pmid/30312335&rft_galeid=A559617803&rft_doaj_id=oai_doaj_org_article_94de0cc0ce3747caa61693ef71982650&rfr_iscdi=true |