MicroRNA and mRNA expression associated with ectopic germinal centers in thymus of myasthenia gravis

A characteristic pathology of early onset myasthenia gravis is thymic hyperplasia with ectopic germinal centers (GC). However, the mechanisms that trigger and maintain thymic hyperplasia are poorly characterized. Dysregulation of small, non-coding microRNAs (miRNAs) and their target genes has been i...

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Veröffentlicht in:	PloS one 2018-10, Vol.13 (10), p.e0205464-e0205464
Hauptverfasser:	Sengupta, Manjistha, Wang, Bi-Dar, Lee, Norman H, Marx, Alexander, Kusner, Linda L, Kaminski, Henry J
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Apoptosis Arthritis Autoimmune diseases Biology and life sciences Care and treatment Cell cycle Cell death Cell growth Cell survival Gene expression Genetic aspects Germinal centers Histology Hyperplasia Immune response Immune system Lupus Lymphocytes Medicine and Health Sciences MicroRNA MicroRNAs miRNA Multiple sclerosis Myasthenia Myasthenia gravis Neuromuscular junctions Pathogenesis Pathology Patients Pharmacology Physiology Proteins Research and Analysis Methods Ribonucleic acid RNA Signal transduction Signaling Studies Target recognition Thymus Transfection Variance analysis
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