Cataract surgery and age-related cognitive decline: A 13-year follow-up of the English Longitudinal Study of Ageing
Visual impairment has been associated with lower cognitive ability among older adults, yet little is known about whether improving visual function with cataract surgery would be associated with slower cognitive decline. This study aimed to assess whether trajectories of cognitive decline differed be...
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| description | Visual impairment has been associated with lower cognitive ability among older adults, yet little is known about whether improving visual function with cataract surgery would be associated with slower cognitive decline. This study aimed to assess whether trajectories of cognitive decline differed before and after cataract surgery and compare those trajectories between older adults with cataract surgery and without cataract.
Data were drawn from the English Longitudinal Study of Ageing (ELSA) Wave 1 (2002/03) until Wave 7 (2014/15). The study population consisted of 2,068 individuals who underwent cataract surgery between Wave 2 and Wave 6 as the treatment group and 3,636 individuals with no cataract as the control group. We included only respondents who took part in a minimum three waves. Propensity score matching method was used to match the individuals in the treatment group with those in the control group. After we put an "artificial" intervention point for the individuals in the control group at the point that the matched person has cataract surgery, spline method was used to identify differences in cognitive trajectories pre- and post-cataract surgery. In the treatment group, we found that cataract surgery was positively associated with episodic memory scores after controlling for the potential covariates (β = 4.23, p |
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Data were drawn from the English Longitudinal Study of Ageing (ELSA) Wave 1 (2002/03) until Wave 7 (2014/15). The study population consisted of 2,068 individuals who underwent cataract surgery between Wave 2 and Wave 6 as the treatment group and 3,636 individuals with no cataract as the control group. We included only respondents who took part in a minimum three waves. Propensity score matching method was used to match the individuals in the treatment group with those in the control group. After we put an "artificial" intervention point for the individuals in the control group at the point that the matched person has cataract surgery, spline method was used to identify differences in cognitive trajectories pre- and post-cataract surgery. In the treatment group, we found that cataract surgery was positively associated with episodic memory scores after controlling for the potential covariates (β = 4.23, p<0.001). Episodic memory scores declined with older age, but the decline in episodic memory scores was slower after cataract surgery (β = -0.05, p<0.001) than before cataract surgery (β = -0.1, p<0.001). Although the episodic memory among respondents in the control group before intervention (β = -0.08, p<0.001) declined slower than those in the intervention group (β = -0.1, p<0.001), the declines in episodic memory scores were similar in both groups after the intervention (control: β = -0.05, p<0.001; intervention: β = -0.05, p<0.001).
Cataract surgery may have a positive impact on trajectories of cognitive decline in later life. Further research is required to identify the mechanism to explain the association between cataract surgery and cognitive ageing, and whether early intervention towards vision correction results in a reduction in dementia risk.]]></description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0204833</identifier><identifier>PMID: 30307960</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adults ; Aged ; Aging ; Biology and Life Sciences ; Case-Control Studies ; Cataract Extraction - methods ; Cataracts ; Cognition & reasoning ; Cognitive ability ; Cognitive Aging ; Cognitive Dysfunction - psychology ; Correlation analysis ; Dementia disorders ; Exercise ; Female ; Humans ; Intervention ; Longitudinal Studies ; Male ; Medicine and Health Sciences ; Memory ; Memory, Episodic ; Middle Aged ; Neuropsychological Tests ; Neurosciences ; Older people ; People and Places ; People with disabilities ; Population studies ; Propensity Score ; Social Sciences ; Surgery ; Trajectory analysis ; Treatment Outcome ; Visual impairment ; Visual perception</subject><ispartof>PloS one, 2018-10, Vol.13 (10), p.e0204833-e0204833</ispartof><rights>2018 Maharani et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 Maharani et al 2018 Maharani et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-2398ab105ae9948ff353ccb93eb946a7ed66ca0bf77608d932c395d0270dcada3</citedby><cites>FETCH-LOGICAL-c526t-2398ab105ae9948ff353ccb93eb946a7ed66ca0bf77608d932c395d0270dcada3</cites><orcidid>0000-0002-5931-8692 ; 0000-0003-3180-9884</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181298/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181298/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,2926,23864,27922,27923,53789,53791,79370,79371</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30307960$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Bayer, Antony</contributor><creatorcontrib>Maharani, Asri</creatorcontrib><creatorcontrib>Dawes, Piers</creatorcontrib><creatorcontrib>Nazroo, James</creatorcontrib><creatorcontrib>Tampubolon, Gindo</creatorcontrib><creatorcontrib>Pendleton, Neil</creatorcontrib><creatorcontrib>SENSE-Cog WP1 group</creatorcontrib><creatorcontrib>on behalf of the SENSE-Cog WP1 group</creatorcontrib><title>Cataract surgery and age-related cognitive decline: A 13-year follow-up of the English Longitudinal Study of Ageing</title><title>PloS one</title><addtitle>PLoS One</addtitle><description><![CDATA[Visual impairment has been associated with lower cognitive ability among older adults, yet little is known about whether improving visual function with cataract surgery would be associated with slower cognitive decline. This study aimed to assess whether trajectories of cognitive decline differed before and after cataract surgery and compare those trajectories between older adults with cataract surgery and without cataract.
Data were drawn from the English Longitudinal Study of Ageing (ELSA) Wave 1 (2002/03) until Wave 7 (2014/15). The study population consisted of 2,068 individuals who underwent cataract surgery between Wave 2 and Wave 6 as the treatment group and 3,636 individuals with no cataract as the control group. We included only respondents who took part in a minimum three waves. Propensity score matching method was used to match the individuals in the treatment group with those in the control group. After we put an "artificial" intervention point for the individuals in the control group at the point that the matched person has cataract surgery, spline method was used to identify differences in cognitive trajectories pre- and post-cataract surgery. In the treatment group, we found that cataract surgery was positively associated with episodic memory scores after controlling for the potential covariates (β = 4.23, p<0.001). Episodic memory scores declined with older age, but the decline in episodic memory scores was slower after cataract surgery (β = -0.05, p<0.001) than before cataract surgery (β = -0.1, p<0.001). Although the episodic memory among respondents in the control group before intervention (β = -0.08, p<0.001) declined slower than those in the intervention group (β = -0.1, p<0.001), the declines in episodic memory scores were similar in both groups after the intervention (control: β = -0.05, p<0.001; intervention: β = -0.05, p<0.001).
Cataract surgery may have a positive impact on trajectories of cognitive decline in later life. Further research is required to identify the mechanism to explain the association between cataract surgery and cognitive ageing, and whether early intervention towards vision correction results in a reduction in dementia risk.]]></description><subject>Adults</subject><subject>Aged</subject><subject>Aging</subject><subject>Biology and Life Sciences</subject><subject>Case-Control Studies</subject><subject>Cataract Extraction - methods</subject><subject>Cataracts</subject><subject>Cognition & reasoning</subject><subject>Cognitive ability</subject><subject>Cognitive Aging</subject><subject>Cognitive Dysfunction - psychology</subject><subject>Correlation analysis</subject><subject>Dementia disorders</subject><subject>Exercise</subject><subject>Female</subject><subject>Humans</subject><subject>Intervention</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Memory</subject><subject>Memory, 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surgery and age-related cognitive decline: A 13-year follow-up of the English Longitudinal Study of Ageing</title><author>Maharani, Asri ; Dawes, Piers ; Nazroo, James ; Tampubolon, Gindo ; Pendleton, Neil</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-2398ab105ae9948ff353ccb93eb946a7ed66ca0bf77608d932c395d0270dcada3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adults</topic><topic>Aged</topic><topic>Aging</topic><topic>Biology and Life Sciences</topic><topic>Case-Control Studies</topic><topic>Cataract Extraction - methods</topic><topic>Cataracts</topic><topic>Cognition & reasoning</topic><topic>Cognitive ability</topic><topic>Cognitive Aging</topic><topic>Cognitive Dysfunction - psychology</topic><topic>Correlation analysis</topic><topic>Dementia 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group</aucorp><aucorp>on behalf of the SENSE-Cog WP1 group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cataract surgery and age-related cognitive decline: A 13-year follow-up of the English Longitudinal Study of Ageing</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2018-10-11</date><risdate>2018</risdate><volume>13</volume><issue>10</issue><spage>e0204833</spage><epage>e0204833</epage><pages>e0204833-e0204833</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract><![CDATA[Visual impairment has been associated with lower cognitive ability among older adults, yet little is known about whether improving visual function with cataract surgery would be associated with slower cognitive decline. This study aimed to assess whether trajectories of cognitive decline differed before and after cataract surgery and compare those trajectories between older adults with cataract surgery and without cataract.
Data were drawn from the English Longitudinal Study of Ageing (ELSA) Wave 1 (2002/03) until Wave 7 (2014/15). The study population consisted of 2,068 individuals who underwent cataract surgery between Wave 2 and Wave 6 as the treatment group and 3,636 individuals with no cataract as the control group. We included only respondents who took part in a minimum three waves. Propensity score matching method was used to match the individuals in the treatment group with those in the control group. After we put an "artificial" intervention point for the individuals in the control group at the point that the matched person has cataract surgery, spline method was used to identify differences in cognitive trajectories pre- and post-cataract surgery. In the treatment group, we found that cataract surgery was positively associated with episodic memory scores after controlling for the potential covariates (β = 4.23, p<0.001). Episodic memory scores declined with older age, but the decline in episodic memory scores was slower after cataract surgery (β = -0.05, p<0.001) than before cataract surgery (β = -0.1, p<0.001). Although the episodic memory among respondents in the control group before intervention (β = -0.08, p<0.001) declined slower than those in the intervention group (β = -0.1, p<0.001), the declines in episodic memory scores were similar in both groups after the intervention (control: β = -0.05, p<0.001; intervention: β = -0.05, p<0.001).
Cataract surgery may have a positive impact on trajectories of cognitive decline in later life. Further research is required to identify the mechanism to explain the association between cataract surgery and cognitive ageing, and whether early intervention towards vision correction results in a reduction in dementia risk.]]></abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>30307960</pmid><doi>10.1371/journal.pone.0204833</doi><orcidid>https://orcid.org/0000-0002-5931-8692</orcidid><orcidid>https://orcid.org/0000-0003-3180-9884</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | PloS one, 2018-10, Vol.13 (10), p.e0204833-e0204833 |
| issn | 1932-6203 1932-6203 |
| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adults Aged Aging Biology and Life Sciences Case-Control Studies Cataract Extraction - methods Cataracts Cognition & reasoning Cognitive ability Cognitive Aging Cognitive Dysfunction - psychology Correlation analysis Dementia disorders Exercise Female Humans Intervention Longitudinal Studies Male Medicine and Health Sciences Memory Memory, Episodic Middle Aged Neuropsychological Tests Neurosciences Older people People and Places People with disabilities Population studies Propensity Score Social Sciences Surgery Trajectory analysis Treatment Outcome Visual impairment Visual perception |
| title | Cataract surgery and age-related cognitive decline: A 13-year follow-up of the English Longitudinal Study of Ageing |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T16%3A44%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cataract%20surgery%20and%20age-related%20cognitive%20decline:%20A%2013-year%20follow-up%20of%20the%20English%20Longitudinal%20Study%20of%20Ageing&rft.jtitle=PloS%20one&rft.au=Maharani,%20Asri&rft.aucorp=SENSE-Cog%20WP1%20group&rft.date=2018-10-11&rft.volume=13&rft.issue=10&rft.spage=e0204833&rft.epage=e0204833&rft.pages=e0204833-e0204833&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0204833&rft_dat=%3Cproquest_plos_%3E2118378883%3C/proquest_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2118378883&rft_id=info:pmid/30307960&rft_doaj_id=oai_doaj_org_article_6cec02ddb9914545a57d1680e6fad7ff&rfr_iscdi=true |